دورية أكاديمية
A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.
العنوان: | A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. |
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المؤلفون: | Mello SS; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA., Valente LJ; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA., Raj N; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA., Seoane JA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Flowers BM; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA., McClendon J; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA., Bieging-Rolett KT; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA., Lee J; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA., Ivanochko D; Princess Margaret Cancer Centre, Structural Genomics Consortium and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Kozak MM; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA., Chang DT; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Longacre TA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Koong AC; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Arrowsmith CH; Princess Margaret Cancer Centre, Structural Genomics Consortium and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Kim SK; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA., Vogel H; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Wood LD; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hruban RH; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Curtis C; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Attardi LD; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: attardi@stanford.edu. |
المصدر: | Cancer cell [Cancer Cell] 2017 Oct 09; Vol. 32 (4), pp. 460-473.e6. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press, c2002- |
مواضيع طبية MeSH: | Nuclear Proteins/*physiology , Pancreatic Neoplasms/*genetics , Protein Tyrosine Phosphatases, Non-Receptor/*physiology , Transcription Factors/*physiology , Tumor Suppressor Protein p53/*physiology, Animals ; Cell Cycle Proteins ; Cell Proliferation ; Cell Transformation, Neoplastic ; Gene Expression Profiling ; Humans ; Mice ; Mutation ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/prevention & control ; Signal Transduction |
مستخلص: | The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed pancreatic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants. Surprisingly, the p53 53,54 TAD2 mutant behaves as a "super-tumor suppressor," with an enhanced capacity to both suppress pancreatic cancer and transactivate select p53 target genes, including Ptpn14. Ptpn14 encodes a negative regulator of the Yap oncoprotein and is necessary and sufficient for pancreatic cancer suppression, like p53. We show that p53 deficiency promotes Yap signaling and that PTPN14 and TP53 mutations are mutually exclusive in human cancers. These studies uncover a p53-Ptpn14-Yap pathway that is integral to p53-mediated tumor suppression. (Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.) |
التعليقات: | Comment in: Cancer Cell. 2017 Oct 9;32(4):397-399. (PMID: 29017051) Comment in: Nat Rev Cancer. 2017 Dec;17 (12 ):706-707. (PMID: 29123244) |
References: | Pancreas. 2010 Oct;39(7):1093-103. (PMID: 20531246) Nature. 2002 Jan 3;415(6867):45-53. (PMID: 11780111) Genes Dev. 2003 Dec 15;17(24):3112-26. (PMID: 14681207) Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517) Mol Cell. 2011 Dec 23;44(6):893-906. (PMID: 22195963) Genes Dev. 2001 Dec 15;15(24):3243-8. (PMID: 11751630) Bioinformatics. 2011 Nov 15;27(22):3206-8. (PMID: 21903630) Oncogene. 2013 Apr 25;32(17):2220-9. (PMID: 22689061) Elife. 2013 Nov 19;2:e00940. (PMID: 24252877) Nat Genet. 2001 Dec;29(4):418-25. (PMID: 11694875) Cancer Discov. 2016 Nov;6(11):1258-1266. (PMID: 27604489) PLoS One. 2013;8(2):e54072. (PMID: 23457446) EMBO J. 2002 Nov 15;21(22):6225-35. (PMID: 12426394) Cell. 2015 Nov 5;163(4):811-28. (PMID: 26544935) Genes Dev. 2006 Oct 1;20(19):2687-700. (PMID: 17015431) Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52. (PMID: 16585505) Nat Rev Cancer. 2014 May;14 (5):359-70. (PMID: 24739573) Nat Med. 2011 Apr;17 (4):500-3. (PMID: 21460848) Genes Dev. 2012 Jun 15;26(12 ):1300-5. (PMID: 22677547) Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886) Br J Cancer. 2014 Apr 2;110(7):1698-704. (PMID: 24569464) Cell. 2009 May 1;137(3):413-31. (PMID: 19410540) Genes Dev. 2006 Nov 15;20(22):3130-46. (PMID: 17114584) Nat Rev Cancer. 2015 Feb;15(2):73-79. (PMID: 25592648) Cell. 2014 Jul 3;158(1):185-197. (PMID: 24954535) Sci Signal. 2014 May 06;7(324):ra42. (PMID: 24803537) Cell. 2012 Jun 8;149(6):1269-83. (PMID: 22682249) Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):175-80. (PMID: 17190805) Nucleic Acids Res. 2015 May 19;43(9):4447-62. (PMID: 25883152) Nat Genet. 2002 Sep;32(1):128-34. (PMID: 12185368) Genes Dev. 2004 Feb 1;18(3):306-19. (PMID: 14871929) Curr Opin Pharmacol. 2016 Aug;29:26-33. (PMID: 27262779) Nat Methods. 2012 Jul;9(7):671-5. (PMID: 22930834) Mol Biol Cell. 2003 Jun;14(6):2520-9. (PMID: 12808048) PLoS One. 2013 Apr 16;8(4):e61916. (PMID: 23613971) Cell. 2011 May 13;145(4):571-83. (PMID: 21565614) Science. 2004 May 21;304(5674):1164-6. (PMID: 15155950) J Biol Chem. 2012 Aug 31;287(36):30376-84. (PMID: 22807444) Genes Dev. 2012 Sep 1;26(17 ):1959-71. (PMID: 22948661) Bioinformatics. 2016 Sep 15;32(18):2847-9. (PMID: 27207943) Cancer Cell. 2003 Dec;4(6):437-50. (PMID: 14706336) Oncogene. 2013 Mar 7;32(10):1266-73. (PMID: 22525271) Genome Biol. 2016 Dec 16;17 (1):261. (PMID: 27986087) Cell. 2008 Mar 21;132(6):945-57. (PMID: 18358808) Mol Cell. 2016 Dec 1;64(5):993-1008. (PMID: 27912098) Cancer Cell. 2016 Jun 13;29(6):783-803. (PMID: 27300434) J Cell Sci. 2010 Aug 1;123(Pt 15):2527-32. (PMID: 20940128) Science. 2008 Sep 26;321(5897):1801-6. (PMID: 18772397) Nature. 2014 Oct 9;514(7521):228-32. (PMID: 25119037) Nature. 2011 Jun 08;474(7350):179-83. (PMID: 21654799) Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17123-8. (PMID: 21969549) Am J Pathol. 2001 May;158(5):1677-83. (PMID: 11337365) Cell Cycle. 2014;13(24):3798-807. (PMID: 25483057) Cell Rep. 2013 May 30;3(5):1339-45. (PMID: 23665218) J Biol Chem. 2005 Nov 18;280(46):38795-802. (PMID: 16159876) Curr Biol. 2012 Mar 6;22(5):389-96. (PMID: 22305752) Genes Dev. 2013 May 1;27(9):1016-31. (PMID: 23651856) N Engl J Med. 2014 Sep 11;371(11):1039-49. (PMID: 25207767) Cancer Cell. 2007 Mar;11(3):229-43. (PMID: 17349581) J Biol Chem. 2014 Aug 22;289(34):23693-700. (PMID: 25023289) Cancer Cell. 2005 May;7(5):469-83. (PMID: 15894267) Nat Genet. 2005 Feb;37(2):145-52. (PMID: 15654339) Trends Biochem Sci. 1997 Feb;22(2):53-8. (PMID: 9048483) Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21. (PMID: 11309499) CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30. (PMID: 26742998) Nat Genet. 2016 Apr;48(4):398-406. (PMID: 26950094) Cold Spring Harb Perspect Med. 2017 Jan 3;7(1):null. (PMID: 27864306) Oncogene. 2013 Apr 18;32(16):2087-95. (PMID: 22710723) Genome Biol. 2014;15(12):550. (PMID: 25516281) |
معلومات مُعتمدة: | R01 CA140875 United States CA NCI NIH HHS; R21 CA169673 United States CA NCI NIH HHS; R35 CA197591 United States CA NCI NIH HHS |
فهرسة مساهمة: | Keywords: Hippo pathway; Ptpn14; YAP; mouse model; p53; pancreas cancer; transactivation domain; tumor suppressor |
المشرفين على المادة: | 0 (Cell Cycle Proteins) 0 (Nuclear Proteins) 0 (TP53 protein, human) 0 (Transcription Factors) 0 (Tumor Suppressor Protein p53) 0 (YY1AP1 protein, human) EC 3.1.3.48 (PTPN14 protein, human) EC 3.1.3.48 (Protein Tyrosine Phosphatases, Non-Receptor) |
تواريخ الأحداث: | Date Created: 20171011 Date Completed: 20171031 Latest Revision: 20220331 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5659188 |
DOI: | 10.1016/j.ccell.2017.09.007 |
PMID: | 29017057 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1878-3686 |
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DOI: | 10.1016/j.ccell.2017.09.007 |