دورية أكاديمية
Clinical and pathological outcomes after irreversible electroporation of the pancreas using two parallel plate electrodes: a porcine model.
| العنوان: | Clinical and pathological outcomes after irreversible electroporation of the pancreas using two parallel plate electrodes: a porcine model. |
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| المؤلفون: | Rombouts SJE; Department of Surgery, University Medical Center Utrecht Cancer Center, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., van Dijck WPM; Department of Surgery, University Medical Center Utrecht Cancer Center, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., Nijkamp MW; Department of Surgery, University Medical Center Utrecht Cancer Center, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., Derksen TC; Department of Surgery, University Medical Center Utrecht Cancer Center, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., Brosens LAA; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., Hoogwater FJH; Department of Surgery, University Medical Center Utrecht Cancer Center, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., van Leeuwen MS; Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., Borel Rinkes IHM; Department of Surgery, University Medical Center Utrecht Cancer Center, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., van Hillegersberg R; Department of Surgery, University Medical Center Utrecht Cancer Center, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., Wittkampf FH; Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands., Molenaar IQ; Department of Surgery, University Medical Center Utrecht Cancer Center, Heidelberglaan 100, 3508 GA, P.O. Box 85500, Utrecht, The Netherlands. Electronic address: i.q.molenaar@umcutrecht.com. |
| المصدر: | HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2017 Dec; Vol. 19 (12), pp. 1058-1065. Date of Electronic Publication: 2017 Oct 10. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 100900921 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2574 (Electronic) Linking ISSN: 1365182X NLM ISO Abbreviation: HPB (Oxford) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Oxford, UK : Elsevier Original Publication: 1999-2001: Oxford, England : ISIS Medical Media |
| مواضيع طبية MeSH: | Ablation Techniques/*instrumentation , Electroporation/*instrumentation , Pancreas/*surgery, Ablation Techniques/adverse effects ; Animals ; Biopsy ; Electrodes ; Equipment Design ; Feasibility Studies ; Female ; Materials Testing ; Models, Animal ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Sus scrofa ; Time Factors ; Tomography, X-Ray Computed |
| مستخلص: | Background: Irreversible electroporation (IRE) by inserting needles around the tumor as treatment for locally advanced pancreatic cancer entails several disadvantages, such as incomplete ablation due to field inhomogeneity, technical difficulties in needle placement and a risk of pancreatic fistula development. This experimental study evaluates outcomes of IRE using paddles in a porcine model. Methods: Six healthy pigs underwent laparotomy and were treated with 2 separate ablations (in head and tail of the pancreas). Follow-up consisted of clinical and laboratory parameters and contrast-enhanced computed tomography (ceCT) imaging. After 2 weeks, pancreatoduodenectomy was performed for histology and the pigs were terminated. Results: All animals survived 14 days. None of the animals developed signs of infection or significant abdominal distention. Serum amylase and lipase peaked at day 1 postoperatively in all pigs, but normalized without signs of pancreatitis. On ceCT-imaging the ablation zone was visible as an ill-defined, hypodense lesion. No abscesses, cysts or ascites were seen. Histology showed a homogenous fibrotic lesion in all pigs. Conclusion: IRE ablation of healthy porcine pancreatic tissue using two plate electrodes is feasible and safe and creates a homogeneous fibrotic lesion. IRE-paddles should be tested on pancreatic adenocarcinoma to determine the effect in cancer tissue. (Copyright © 2017. Published by Elsevier Ltd.) |
| تواريخ الأحداث: | Date Created: 20171015 Date Completed: 20180716 Latest Revision: 20191210 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.hpb.2017.02.443 |
| PMID: | 29029985 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1477-2574 |
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| DOI: | 10.1016/j.hpb.2017.02.443 |