دورية أكاديمية
أعرض في EDS

Low efficacy of atopy patch test in predicting tolerance development in non-IgE-mediated cow's milk allergy.

التفاصيل البيبلوغرافية
العنوان: Low efficacy of atopy patch test in predicting tolerance development in non-IgE-mediated cow's milk allergy.
المؤلفون: Gonzaga TA; Food Allergy Research Group, Pediatrics Department, Universidade Federal de Uberlandia, Brazil., Alves FA; Food Allergy Research Group, Pediatrics Department, Universidade Federal de Uberlandia, Brazil., Cheik MFA; Food Allergy Research Group, Pediatrics Department, Universidade Federal de Uberlandia, Brazil., de Barros CP; Food Allergy Research Group, Pediatrics Department, Universidade Federal de Uberlandia, Brazil., Rezende ERMA; Food Allergy Research Group, Pediatrics Department, Universidade Federal de Uberlandia, Brazil., Segundo GRS; Food Allergy Research Group, Pediatrics Department, Universidade Federal de Uberlandia, Brazil. Electronic address: gesmar@famed.ufu.br.
المصدر: Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 2018 May - Jun; Vol. 46 (3), pp. 241-246. Date of Electronic Publication: 2017 Oct 12.
نوع المنشور: Clinical Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Codon Publications Country of Publication: Singapore NLM ID: 0370073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1578-1267 (Electronic) Linking ISSN: 03010546 NLM ISO Abbreviation: Allergol Immunopathol (Madr) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Singapore] : Codon Publications
Original Publication: Madrid : Elsevier España
مواضيع طبية MeSH: Milk Hypersensitivity/*diagnosis , Patch Tests/*methods, Allergens/administration & dosage ; Allergens/immunology ; Animals ; Cattle ; Child, Preschool ; Female ; Humans ; Immune Tolerance/immunology ; Infant ; Male ; Milk Proteins/administration & dosage ; Milk Proteins/immunology ; Sensitivity and Specificity
مستخلص: Background: The food atopy patch (APT) test has been used in previous studies to help the diagnosis of non-IgE mediated food allergies (FA). The aim of this study was to evaluate the efficacy of different cow's milk APT preparations to predict oral tolerance in children with previous non-IgE-mediated cow's milk allergy (CMA) diagnosis.
Methods: Thirty-two patients non-IgE-mediated CMA diagnosed by oral food challenge (OFC) were enrolled to perform APT with three different cow's milk preparations (fresh, 2% in saline solution, 2% in petrolatum) and comparing with a new OFC after at least three months of diet exclusion.
Results: Only six (18.7%) subjects presented positive OFC to cow's milk. No differences in gender, onset symptoms age, OFC age, Z-score, and exclusion period were found between positive and negative OFC patients. Preparations using fresh milk and powdered milk in petrolatum presented sensitivity equal to zero and specificity 92.3% and 96.1%. The preparation using powdered milk in saline solution showed sensitivity and specificity of 33.3% and 96.1%. Two patients presented typical IgE symptoms after OFC.
Conclusion: Cow's milk APT presented a low efficacy to predict tolerance in patients with previous non-IgE-mediated CMA and should not be used in clinical routine. The presence of typical IgE reactions after OFC hallmark the necessity of previous IgE-mediated investigation for this patient group.
(Copyright © 2017 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.)
فهرسة مساهمة: Keywords: Atopy patch test; Cow's milk allergy; Non-IgE-mediated food allergy
المشرفين على المادة: 0 (Allergens)
0 (Milk Proteins)
تواريخ الأحداث: Date Created: 20171017 Date Completed: 20180924 Latest Revision: 20180924
رمز التحديث: 20231215
DOI: 10.1016/j.aller.2017.07.001
PMID: 29031891
قاعدة البيانات: MEDLINE
الوصف
تدمد:1578-1267
DOI:10.1016/j.aller.2017.07.001