دورية أكاديمية
Majority of flat epithelial atypia diagnosed on biopsy do not require surgical excision.
| العنوان: | Majority of flat epithelial atypia diagnosed on biopsy do not require surgical excision. |
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| المؤلفون: | Chan PMY; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Chotai N; Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore 308433, Singapore., Lai ES; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Sin PY; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Chen J; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Lu SQ; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Goh MH; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Chong BK; Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore 308433, Singapore., Ho BCS; Department of Pathology, Tan Tock Seng Hospital, Singapore 308433, Singapore., Tan EY; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore. Electronic address: Ern_Yu_Tan@ttsh.com.sg. |
| المصدر: | Breast (Edinburgh, Scotland) [Breast] 2018 Feb; Vol. 37, pp. 13-17. Date of Electronic Publication: 2017 Oct 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9213011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3080 (Electronic) Linking ISSN: 09609776 NLM ISO Abbreviation: Breast Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Amsterdam : Elsevier Original Publication: Edinburgh ; New York : Churchill Livingstone, c1992- |
| مواضيع طبية MeSH: | Breast/*pathology , Breast Neoplasms/*pathology , Carcinoma, Intraductal, Noninfiltrating/*pathology , Epithelial Cells/*pathology, Adult ; Aged ; Animals ; Biopsy ; Breast/diagnostic imaging ; Breast Neoplasms/diagnosis ; Breast Neoplasms/surgery ; Calcinosis/diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating/diagnosis ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Female ; Follow-Up Studies ; Humans ; Mammography ; Middle Aged ; Neoplasm Grading ; Retrospective Studies ; Young Adult |
| مستخلص: | Background: Borderline risk lesions such as flat epithelial atypia (FEA) are increasingly being diagnosed on biopsy. The need for surgery is being debated. In this study, we determined the frequency of histological upgrade following a diagnosis of FEA on biopsy and evaluated potential predictive factors. Methods: Retrospective review was done of 194 women who underwent biopsy of indeterminate lesions (total 195 lesions) that were diagnosed as FEA. The review covered a 10-year period. Cases where malignancy was also present together with FEA within the same biopsy cores were excluded. Results: Lesions diagnosed as FEA on biopsy were mostly asymptomatic and presented as microcalcifications on mammogram. Flat epithelial atypia was the only abnormality detected in one-third of cases, was associated with a benign or another borderline lesion in another third and was associated with atypical ductal hyperplasia (ADH) in another third. Six patients (3.1%) were later found to have ductal carcinoma-in-situ (DCIS) at surgery. The presence of ADH in the biopsy was the only predictor of histological upgrade to malignancy (P = 0.04, OR 11.24, 95% CI 1.10 - 115.10), and was present in 5 of the 6 patients. Surgery was advised in the last patient because of radiology-pathology discordance. Thirty-six lesions (18.5%) were not excised and no interval progression or malignancy was found on follow up. Conclusion: Histological upgrade to malignancy was uncommon in lesions found on biopsy to be FEA. Non-operative management of biopsy-proven FEA can be considered in the absence of ADH and radiology-pathology discordance. (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biopsy; Flat epithelial atypia; Surgery |
| تواريخ الأحداث: | Date Created: 20171018 Date Completed: 20180731 Latest Revision: 20180731 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.breast.2017.10.005 |
| PMID: | 29040892 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-3080 |
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| DOI: | 10.1016/j.breast.2017.10.005 |