دورية أكاديمية
5,6-dehydrokawain from the rhizome of Alpinia mutica Roxb. induced proangiogenic tumour-derived VEGF of HT-29 colorectal cancer.
| العنوان: | 5,6-dehydrokawain from the rhizome of Alpinia mutica Roxb. induced proangiogenic tumour-derived VEGF of HT-29 colorectal cancer. |
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| المؤلفون: | Malami I; a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Ethnopharmacy , Usmanu Danfodiyo University , Sokoto , Nigeria., Muhammad A; b Faculty of Life Sciences, Department of Biochemistry , Ahmadu Bello University , Zaria , Nigeria., Abubakar IB; c Department of Biochemistry , Kebbi State University , Aliero , Nigeria., Etti IC; d Department of Pharmacology and Toxicology , University of Uyo , Uyo , Nigeria., Waziri PM; e Department of Biochemistry , Kaduna State University , Kaduna , Nigeria., Abubakar RM; f Faculty of Pharmaceutical Sciences, Department of Pharmacology and Toxicology , Usmanu Danfodiyo University , Sokoto , Nigeria., Mshelia HE; a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Ethnopharmacy , Usmanu Danfodiyo University , Sokoto , Nigeria. |
| المصدر: | Natural product research [Nat Prod Res] 2018 Dec; Vol. 32 (24), pp. 2964-2967. Date of Electronic Publication: 2017 Oct 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Alpinia/*chemistry , Colorectal Neoplasms/*metabolism , Pyrones/*pharmacology , Rhizome/*chemistry , Vascular Endothelial Growth Factor A/*drug effects, Alpinia/anatomy & histology ; Angiogenesis Modulating Agents/isolation & purification ; Angiogenesis Modulating Agents/pharmacology ; Cell Proliferation/drug effects ; Colorectal Neoplasms/pathology ; HT29 Cells ; Humans ; Neovascularization, Pathologic/chemically induced ; Plant Extracts/pharmacology ; Pyrones/isolation & purification ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism |
| مستخلص: | Vascular endothelial growth factor (VEGF) is a glycoprotein vital to the regulation of vascular endothelial cells proliferation, migration and angiogenesis. The expression of VEGF is required for the formation of new blood vessels critical in supplying oxygen and nutrition in the course of tumorigenesis. The present study investigated the effect of 5,6-dehydrokawain isolated from the rhizomes of Alpinia mutica on VEGF expression in vitro using HT-29 cell line. The results revealed that 5,6-dehydrokawain induced the expression of proangiogenic tumour-derived VEGF of HT-29 cells, which may explain the inability of 5,6-dehydrokawain in suppressing cancer cells proliferation. |
| فهرسة مساهمة: | Keywords: 5,6-dehydrokawain; VEGF; angiogenesis, HT-29 cells |
| المشرفين على المادة: | 0 (Angiogenesis Modulating Agents) 0 (Plant Extracts) 0 (Pyrones) 0 (Vascular Endothelial Growth Factor A) 1952-41-6 (5,6-dehydrokawain) |
| تواريخ الأحداث: | Date Created: 20171021 Date Completed: 20190515 Latest Revision: 20190515 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14786419.2017.1392954 |
| PMID: | 29052437 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2017.1392954 |