دورية أكاديمية
[Overall intestinal permeability of multiple components in lotus leaf by in situ single pass intestinal perfusion models].
| العنوان: | [Overall intestinal permeability of multiple components in lotus leaf by in situ single pass intestinal perfusion models]. |
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| المؤلفون: | Yin XW; Beijing University of Chinese Medicine, Beijing 100102, China., Hou CB; Beijing University of Chinese Medicine, Beijing 100102, China., Chen JP; Beijing University of Chinese Medicine, Beijing 100102, China., Pan M; Beijing University of Chinese Medicine, Beijing 100102, China., Li XL; Beijing University of Chinese Medicine, Beijing 100102, China., Wang ZY; Beijing University of Chinese Medicine, Beijing 100102, China., Dong L; Beijing University of Chinese Medicine, Beijing 100102, China. |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2017 Apr; Vol. 42 (8), pp. 1525-1531. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Intestinal Absorption*, Intestines/*drug effects , Nelumbo/*chemistry , Plant Extracts/*pharmacokinetics, Animals ; Biopharmaceutics ; Perfusion ; Permeability ; Plant Leaves/chemistry ; Rats |
| مستخلص: | To investigate the overall intestinal permeability of multiple components in lotus leaves and make clear the interaction in composition absorption process. Rat single-pass intestinal perfusion technique was used, and the results showed that the Peff values of nuciferine, demethylanuciferine, rutin, quercetin, kaempferol from lotus leaf were greater than 0.5×10⁻⁴ cm•s⁻¹. In the biopharmaceutics classification system (BCS) intestinal permeability property, these ingredients were high permeable components, while the hyperin was low permeable component. However, in the multi-component environment of the lotus leaf extract, component permeation was changed. Semi quantitative analysis of the unclear components showed that under the multi-component environment, four in seven components with relatively high contents had a Peff value less than 0.5×10⁻⁴ cm•s⁻¹, indicating these 4 components were of low permeability, while other 3 components were of high permeability. The results could be valuable to make clear the overall intestinal permeability of multiple components in lotus leaf, and lay a foundation for studying the mechanism of the lipid-lowering effect of lotus leaf. Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. (Copyright© by the Chinese Pharmaceutical Association.) |
| فهرسة مساهمة: | Keywords: biopharmaceutics classification system of Chinese materia medica; lotus leaf; permeability; single-pass intestinal perfusion(SPIP) |
| المشرفين على المادة: | 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20171027 Date Completed: 20180625 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.19540/j.cnki.cjcmm.20170223.006 |
| PMID: | 29071857 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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| DOI: | 10.19540/j.cnki.cjcmm.20170223.006 |