دورية أكاديمية
Predictors of death in chronic Chagas cardiomyopathy patients with pacemaker.
| العنوان: | Predictors of death in chronic Chagas cardiomyopathy patients with pacemaker. |
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| المؤلفون: | Peixoto GL; Heart Institute (InCor), University of São Paulo Medical School, Brazil. Electronic address: gisellepeixoto@ig.com.br., Martinelli Filho M; Heart Institute (InCor), University of São Paulo Medical School, Brazil., Siqueira SF; Heart Institute (InCor), University of São Paulo Medical School, Brazil., Nishioka SAD; Heart Institute (InCor), University of São Paulo Medical School, Brazil., Pedrosa AAA; Heart Institute (InCor), University of São Paulo Medical School, Brazil., Teixeira RA; Heart Institute (InCor), University of São Paulo Medical School, Brazil., Costa R; Heart Institute (InCor), University of São Paulo Medical School, Brazil., Kalil Filho R; Heart Institute (InCor), University of São Paulo Medical School, Brazil., Ramires JAF; Heart Institute (InCor), University of São Paulo Medical School, Brazil. |
| المصدر: | International journal of cardiology [Int J Cardiol] 2018 Jan 01; Vol. 250, pp. 260-265. Date of Electronic Publication: 2017 Oct 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981- |
| مواضيع طبية MeSH: | Chagas Cardiomyopathy/*diagnosis , Chagas Cardiomyopathy/*mortality , Pacemaker, Artificial/*trends, Aged ; Chronic Disease ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Mortality/trends ; Predictive Value of Tests ; Prospective Studies |
| مستخلص: | Background: Chronic Chagas cardiomyopathy (CCC) is the most serious and frequent manifestation of Chagas disease. Conduction abnormalities and bradycardia requiring pacemaker are common. The aim of this study was to determine the rate and predictors of death in CCC patients with pacemaker. Methods: In this single-center prospective cohort study we assessed the outcome of 396 CCC patients with pacemaker, followed-up for at least 24months. All patients underwent a clinical and device assessment, 12-lead electrocardiography and echocardiography. Results: During the median follow-up of 1.9years (Interquartile range 1.6-2.4), there were 65 (16.4%) deaths, yielding an annual mortality rate of 8.6%. The major cause was sudden death (33.8%), followed by heart failure (HF), 32.3%. All the investigated variables were examined as potential predictors of death. The final multivariate logistic regression model included five independent variables: advanced HF functional class (OR [odds ratio] 6.71; 95% confidence interval [95% CI] 1.95-23.2; P=0.003), renal disease (OR 5.71; 95% CI 1.80-18.0; P=0.003), QRS ≥150ms (OR 2.80; 95% CI 1.08-7.27; P=0.034), left atrial enlargement (OR 2.75; 95% CI 1.09-6.95; P=0.032) and left ventricular ejection fraction ≤43% (OR 2.31; 95% CI 1.07-4.97; P=0.032). The model had good discrimination, confirmed by bootstrap validation (optimism-adjusted c-statistic of 0.78) and the calibration curve showed a proper calibration (slope=0.972). Conclusions: CCC patients with pacemaker have a high annual mortality rate despite that the pacemaker related variables were not predictors of death. The independent predictors of death can help us to identify the poor prognosis patients. (Copyright © 2017 Elsevier B.V. All rights reserved.) |
| التعليقات: | Comment in: Int J Cardiol. 2018 Jun 1;260:137. (PMID: 29622429) Comment in: Int J Cardiol. 2018 Jun 1;260:20. (PMID: 29622442) |
| فهرسة مساهمة: | Keywords: Chronic Chagas cardiomyopathy; Death; Pacemaker |
| تواريخ الأحداث: | Date Created: 20171029 Date Completed: 20180713 Latest Revision: 20180713 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ijcard.2017.10.031 |
| PMID: | 29079412 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1874-1754 |
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| DOI: | 10.1016/j.ijcard.2017.10.031 |