دورية أكاديمية
Invasive candidiasis in a neonatal intensive care unit in Lagos, Nigeria.
العنوان: | Invasive candidiasis in a neonatal intensive care unit in Lagos, Nigeria. |
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المؤلفون: | Ezenwa BN; Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria., Oladele RO; Department of Microbiology and Parasitology, Lagos University Teaching Hospital, Lagos, Nigeria., Akintan PE; Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria., Fajolu IB; Department of Microbiology and Parasitology, Lagos University Teaching Hospital, Lagos, Nigeria., Oshun PO; Department of Microbiology and Parasitology, Lagos University Teaching Hospital, Lagos, Nigeria., Oduyebo OO; Department of Microbiology and Parasitology, Lagos University Teaching Hospital, Lagos, Nigeria., Ezeaka VC; Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria. |
المصدر: | The Nigerian postgraduate medical journal [Niger Postgrad Med J] 2017 Jul-Sep; Vol. 24 (3), pp. 150-154. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: published by Wolters Kluwer-Medknow for the Nigerian Postgraduate Medical College of Nigeria Country of Publication: Nigeria NLM ID: 9613595 Publication Model: Print Cited Medium: Print ISSN: 1117-1936 (Print) NLM ISO Abbreviation: Niger Postgrad Med J Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2015- > : Mumbai : published by Wolters Kluwer-Medknow for the Nigerian Postgraduate Medical College of Nigeria Original Publication: Ebute Metta, Lagos, Nigeria : National Postgraduate Medical College of Nigeria, [1994- |
مواضيع طبية MeSH: | Intensive Care Units, Neonatal*, Candida/*isolation & purification , Candidiasis, Invasive/*epidemiology, Candidemia/epidemiology ; Candidiasis, Invasive/diagnosis ; Candidiasis, Invasive/microbiology ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Nigeria/epidemiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Sex Distribution |
مستخلص: | Background: Invasive candidiasis has been identified globally as a major cause of morbidity and mortality in neonatal intensive care units (NICU). Systemic candidiasis presents like bacterial sepsis and can involve multiple organs. Objective: The objective of this study was to determine the prevalence of Candida infection in a NICU at a tertiary hospital in Nigeria and to identify its associated risk factors. Materials and Methods: The study was a retrospective descriptive study of all cases of culture-proven invasive Candida infection (ICI) in neonates admitted to the NICU over a 4-year period. The study participants were identified from microbiology records of all neonates with a positive Candida culture. Medical records of identified neonates were also reviewed, and relevant information obtained. Results: Over the 4 years, 2712 newborns were admitted to the NICU. From these, 1182 various clinical samples were collected from babies with features of sepsis and processed in the medical microbiology laboratory. Twenty-seven (2.3%) of the cultures yielded Candida organisms; fifteen of the Candida cultures were from male infants with a male:female ratio of 1.3:1. Bloodstream infection was the most frequent ICI seen in preterm babies (seven [58.3%] out of 12 babies with ICI). Nearly, all (91.7%) affected preterm infants with ICI were <1500 g in weight. All were exposed to invasive procedures and broad-spectrum antibiotics. The case fatality rate among those with ICI was 18.5%. Conclusion: There was a significant prevalence of invasive candidiasis in high-risk newborns and the incidence increases with increased practices in risk factors such as invasive procedures and antibiotic use and lower gestational age babies with very low birth weight. |
تواريخ الأحداث: | Date Created: 20171031 Date Completed: 20190415 Latest Revision: 20190415 |
رمز التحديث: | 20240628 |
DOI: | 10.4103/npmj.npmj_104_17 |
PMID: | 29082903 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1117-1936 |
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DOI: | 10.4103/npmj.npmj_104_17 |