دورية أكاديمية
أعرض في EDS

Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients.

التفاصيل البيبلوغرافية
العنوان: Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients.
المؤلفون: Genazzani AD; Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy. algen@unimo.it., Shefer K; Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy., Della Casa D; Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy., Prati A; Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy., Napolitano A; Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy., Manzo A; Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy., Despini G; Department of Obstetrics and Gynecology, Gynecological Endocrinology Center, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy., Simoncini T; Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy.
المصدر: Journal of endocrinological investigation [J Endocrinol Invest] 2018 May; Vol. 41 (5), pp. 583-590. Date of Electronic Publication: 2017 Oct 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : Berlin : Springer
Original Publication: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis.
مواضيع طبية MeSH: Insulin Resistance*, Antioxidants/*administration & dosage , Diabetes Mellitus/*drug therapy , Obesity/*drug therapy , Polycystic Ovary Syndrome/*drug therapy , Thioctic Acid/*administration & dosage, Adult ; Body Mass Index ; Diabetes Mellitus/pathology ; Female ; Follow-Up Studies ; Humans ; Obesity/complications ; Obesity/pathology ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/pathology ; Prognosis ; Young Adult
مستخلص: Purpose: To evaluate the efficacy of alpha-lipoic acid (ALA) administration on hormonal and metabolic parameters of obese PCOS patients.
Methods: A group of 32 obese PCOS patients were selected after informed consent. 20 patients referred to have first grade relatives with diabetes type I or II. Hormonal and metabolic parameters as well as OGTT were evaluated before and after 12 weeks of ALA integrative administration (400 mg per os every day).
Results: ALA administration significantly decreased insulin, glucose, BMI and HOMA index. Hyperinsulinemia and insulin response to OGTT decreased both as maximal response (Δmax) and as AUC. PCOS with diabetes relatives showed the decrease also of triglyceride and GOT. Interestingly in all PCOS no changes occurred on all hormonal parameters involved in reproduction such as LH, FSH, and androstenedione.
Conclusions: ALA integrative administration at a low dosage as 400 mg daily improved the metabolic impairment of all PCOS patients especially in those PCOS with familiar diabetes who have a higher grade of risk of NAFLD and predisposition to diabetes.
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فهرسة مساهمة: Keywords: Alpha-lipoic-acid; Familiar diabetes; Hyperinsulinemia; Insulin resistance; PCOS
المشرفين على المادة: 0 (Antioxidants)
73Y7P0K73Y (Thioctic Acid)
تواريخ الأحداث: Date Created: 20171102 Date Completed: 20181009 Latest Revision: 20181113
رمز التحديث: 20221213
DOI: 10.1007/s40618-017-0782-z
PMID: 29090431
قاعدة البيانات: MEDLINE
الوصف
تدمد:1720-8386
DOI:10.1007/s40618-017-0782-z