دورية أكاديمية
أعرض في EDS

Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats.

التفاصيل البيبلوغرافية
العنوان: Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats.
المؤلفون: El Rabey HA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.; Bioinformatics Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, P.O. Box 79, Sadat City, Egypt., Al-Seeni MN; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Al-Ghamdi HB; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
المصدر: BioMed research international [Biomed Res Int] 2017; Vol. 2017, pp. 3098745. Date of Electronic Publication: 2017 Sep 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Galactans/*chemistry , Hypercholesterolemia/*diet therapy , Mannans/*chemistry , Obesity/*diet therapy , Petroselinum/*chemistry , Plant Extracts/*administration & dosage , Plant Gums/*chemistry, Animals ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/pathology ; Obesity/blood ; Obesity/pathology ; Plant Extracts/chemistry ; Rats ; Seeds/chemistry ; Triglycerides/blood
مستخلص: Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes. The hepatocardioprotective activity of parsley and carob methanol extract was tested in hypercholesterolemic male rats. Twenty-four male albino rats were divided into four groups ( n = 6). Group 1 was the negative control group fed with fat rich diet, group 2 (G2) was hypercholesterolemic rats fed with fat rich diet with 2% cholesterol, and group 3 and group 4 (G3 and G4) were hypercholesterolemic rats supplemented with 2% cholesterol and cotreated with 20% w/w parsley seed methanol extract and 20% w/w carob legume methanol extract, respectively. The experiment was conducted for eight weeks. The positive hypercholesterolemic rats showed significant increase in serum levels of total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), lactate dehydrogenase (LDH), creatine kinase-mb, liver function enzymes, and decrease in the high density lipoproteins (HDL). Moreover, heart and liver tissues were ameliorated and nearly restored their normal appearance. It could be concluded that both parsley and carob extracts supplementations have a protective effect against hyperlipidemia and improved the histological alteration in heart and liver tissues. The methanol extract of parsley appeared to be more efficient than that of carob in lowering hypercholesterolemia.
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المشرفين على المادة: 0 (Cholesterol, HDL)
0 (Cholesterol, LDL)
0 (Galactans)
0 (Mannans)
0 (Plant Extracts)
0 (Plant Gums)
0 (Triglycerides)
97C5T2UQ7J (Cholesterol)
V4716MY704 (locust bean gum)
تواريخ الأحداث: Date Created: 20171103 Date Completed: 20180615 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5637854
DOI: 10.1155/2017/3098745
PMID: 29094044
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2017/3098745