دورية أكاديمية
أعرض في EDS

Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking.

التفاصيل البيبلوغرافية
العنوان: Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking.
المؤلفون: Ben Hamida S; Département de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U-964, CNRS UMR-7104, Université de Strasbourg, France.; Douglas Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Canada., Boulos LJ; Département de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U-964, CNRS UMR-7104, Université de Strasbourg, France.; Douglas Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Canada., McNicholas M; Douglas Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Canada., Charbogne P; Douglas Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Canada.; Current position: Department of Neuroscience, School of Medicine, Brain Science Institute, Johns Hopkins University, Baltimore, MD, USA., Kieffer BL; Département de Médecine Translationnelle et Neurogénétique, Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U-964, CNRS UMR-7104, Université de Strasbourg, France.; Douglas Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Canada.
المصدر: Addiction biology [Addict Biol] 2019 Jan; Vol. 24 (1), pp. 28-39. Date of Electronic Publication: 2017 Nov 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1369-1600 (Electronic) Linking ISSN: 13556215 NLM ISO Abbreviation: Addict Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Hoboken, NJ : Wiley-Blackwell
Original Publication: Abingdon, Oxfordshire, UK ; Cambridge, MA : Carfax, c1996-
مواضيع طبية MeSH: Reward*, Alcohol Drinking/*genetics , Central Nervous System Depressants/*administration & dosage , Ethanol/*administration & dosage , GABAergic Neurons/*metabolism , Neostriatum/*metabolism , Receptors, Opioid, mu/*genetics , Ventral Tegmental Area/*metabolism, Alcohol Drinking/metabolism ; Animals ; Behavior, Animal ; Mesencephalon/metabolism ; Mice ; Mice, Knockout ; Prosencephalon/metabolism ; Rhombencephalon/metabolism ; Self Administration
مستخلص: Mu opioid receptors (MORs) are widely distributed throughout brain reward circuits and their role in drug and social reward is well established. Substantial evidence has implicated MOR and the endogenous opioid system in alcohol reward, but circuit mechanisms of MOR-mediated alcohol reward and intake behavior remain elusive, and have not been investigated by genetic approaches. We recently created conditional knockout (KO) mice targeting the Oprm1 gene in GABAergic forebrain neurons. These mice (Dlx-MOR KO) show a major MOR deletion in the striatum, whereas receptors in midbrain (including the Ventral Tegmental Area or VTA) and hindbrain are intact. Here, we compared alcohol-drinking behavior and rewarding effects in total (MOR KO) and conditional KO mice. Concordant with our previous work, MOR KO mice drank less alcohol in continuous and intermittent two-bottle choice protocols. Remarkably, Dlx-MOR KO mice showed reduced drinking similar to MOR KO mice, demonstrating that MOR in the forebrain is responsible for the observed phenotype. Further, alcohol-induced conditioned place preference was detected in control but not MOR KO mice, indicating that MOR is essential for alcohol reward and again, Dlx-MOR KO recapitulated the MOR KO phenotype. Taste preference and blood alcohol levels were otherwise unchanged in mutant lines. Together, our data demonstrate that MOR expressed in forebrain GABAergic neurons is essential for alcohol reward-driven behaviors, including drinking and place conditioning. Challenging the prevailing VTA-centric hypothesis, this study reveals another mechanism of MOR-mediated alcohol reward and consumption, which does not necessarily require local VTA MORs but rather engages striatal MOR-dependent mechanisms.
(© 2017 Society for the Study of Addiction.)
References: Pharmacopsychiatry. 2016 Mar;49(2):66-75. (PMID: 26845589)
Alcohol Alcohol. 2014 May-Jun;49(3):261-70. (PMID: 24421289)
Alcohol Clin Exp Res. 2003 Feb;27(2):220-31. (PMID: 12605071)
Alcohol. 2014 May;48(3):243-52. (PMID: 24721195)
Eur Neuropsychopharmacol. 2015 Aug;25(8):1128-35. (PMID: 25937240)
Alcohol Clin Exp Res. 2003 Jul;27(7):1142-9. (PMID: 12878920)
Trends Neurosci. 2015 Apr;38(4):217-25. (PMID: 25637939)
Neuropsychopharmacology. 2010 Jan;35(1):27-47. (PMID: 19675534)
J Pharmacol Exp Ther. 2000 Jun;293(3):1002-8. (PMID: 10869404)
Psychopharmacology (Berl). 2013 Jul;228(2):207-15. (PMID: 23430162)
Physiol Behav. 2009 Oct 19;98(4):453-9. (PMID: 19647755)
Alcohol Clin Exp Res. 2001 Jan;25(1):25-33. (PMID: 11198711)
Prog Neurobiol. 2010 Jan 11;90(1):1-15. (PMID: 19800387)
Science. 2004 Jun 25;304(5679):1983-6. (PMID: 15218152)
Lancet Psychiatry. 2016 Aug;3(8):760-773. (PMID: 27475769)
ILAR J. 2012;53(1):35-58. (PMID: 23520598)
Nat Rev Neurosci. 2011 Oct 05;12(11):685-700. (PMID: 21971065)
Psychopharmacology (Berl). 2010 Jan;208(1):121-30. (PMID: 19940981)
Biol Psychiatry. 2017 May 1;81(9):778-788. (PMID: 28185645)
Alcohol Clin Exp Res. 2002 Sep;26(9):1381-7. (PMID: 12351933)
Curr Opin Neurobiol. 2004 Jun;14(3):370-8. (PMID: 15194118)
J Psychopharmacol. 2014 Jan;28(1):8-22. (PMID: 24048097)
Neuropsychopharmacology. 2010 Aug;35(9):1841-9. (PMID: 20393452)
Psychopharmacology (Berl). 2015 Sep;232(18):3431-41. (PMID: 26141191)
Biol Psychiatry. 2008 Dec 1;64(11):989-97. (PMID: 18589403)
Addict Biol. 2017 Sep;22(5):1205-1217. (PMID: 27126842)
Psychopharmacology (Berl). 2013 Aug;228(3):389-400. (PMID: 23503684)
Neuroscience. 2014 Sep 26;277:595-609. (PMID: 25086313)
Curr Top Behav Neurosci. 2013;13:355-77. (PMID: 22371267)
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11603-11608. (PMID: 27671662)
Sci Transl Med. 2012 Jan 11;4(116):116ra6. (PMID: 22238334)
Neuropsychopharmacology. 2003 Apr;28(4):755-64. (PMID: 12655322)
Neuron. 2006 Aug 17;51(4):455-66. (PMID: 16908411)
Physiol Rev. 2009 Oct;89(4):1379-412. (PMID: 19789384)
Alcohol Clin Exp Res. 2009 Jun;33(6):1033-43. (PMID: 19302084)
Psychopharmacology (Berl). 2001 Feb;154(1):43-9. (PMID: 11292005)
Nature. 1996 Oct 31;383(6603):819-23. (PMID: 8893006)
Alcohol Clin Exp Res. 2008 Jul;32(7):1113-23. (PMID: 18540916)
Drug Alcohol Depend. 2010 Mar 1;107(2-3):221-9. (PMID: 19969427)
Brain Struct Funct. 2015 Mar;220(2):677-702. (PMID: 24623156)
Neuropsychopharmacology. 2014 Aug;39(9):2049-60. (PMID: 24619243)
Pharmacol Ther. 2004 Aug;103(2):121-46. (PMID: 15369680)
Alcohol Clin Exp Res. 1999 Sep;23(9):1468-76. (PMID: 10512312)
Alcohol. 1994 Nov-Dec;11(6):557-64. (PMID: 7865158)
Neuropharmacology. 2011 Jul-Aug;61(1-2):35-42. (PMID: 21338616)
J Clin Psychopharmacol. 2006 Dec;26(6):610-25. (PMID: 17110818)
Trends Neurosci. 1999 Nov;22(11):521-7. (PMID: 10529820)
Physiol Rev. 2009 Apr;89(2):649-705. (PMID: 19342616)
Neuropharmacology. 2014 Jan;76 Pt B:204-17. (PMID: 24035914)
Alcohol Clin Exp Res. 2006 Jun;30(6):982-90. (PMID: 16737456)
معلومات مُعتمدة: International Institut National de la Santé et de la Recherche Médicale (INSERM); P50 DA005010 United States DA NIDA NIH HHS; International Centre National de la Recherche Scientifique (CNRS); NIAAA #16658 United States NH NIH HHS; International Université de Strasbourg; International Canada Research Chairs; NIDA # 005010 United States NH NIH HHS; U01 AA016658 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: alcohol intake; forebrain GABAergic neurons; mu opioid receptor
المشرفين على المادة: 0 (Central Nervous System Depressants)
0 (Oprm protein, mouse)
0 (Receptors, Opioid, mu)
3K9958V90M (Ethanol)
تواريخ الأحداث: Date Created: 20171103 Date Completed: 20200402 Latest Revision: 20231112
رمز التحديث: 20231112
مُعرف محوري في PubMed: PMC5932272
DOI: 10.1111/adb.12576
PMID: 29094432
قاعدة البيانات: MEDLINE
الوصف
تدمد:1369-1600
DOI:10.1111/adb.12576