دورية أكاديمية
أعرض في EDS

Effects of barium chloride adsorbed to polyethylene glycol (PEG) microspheres on co-culture of human blood mononuclear cell and breast cancer cell lines (MCF-7).

التفاصيل البيبلوغرافية
العنوان: Effects of barium chloride adsorbed to polyethylene glycol (PEG) microspheres on co-culture of human blood mononuclear cell and breast cancer cell lines (MCF-7).
المؤلفون: da Silva FH; a Institute of Biological and Health Science, Federal University of Mato Grosso , Barra do Garças , Mato Grosso , Brazil., Ribeiro AAL; a Institute of Biological and Health Science, Federal University of Mato Grosso , Barra do Garças , Mato Grosso , Brazil., Deluque AL; a Institute of Biological and Health Science, Federal University of Mato Grosso , Barra do Garças , Mato Grosso , Brazil., Cotrim ACM; a Institute of Biological and Health Science, Federal University of Mato Grosso , Barra do Garças , Mato Grosso , Brazil., de Marchi PGF; a Institute of Biological and Health Science, Federal University of Mato Grosso , Barra do Garças , Mato Grosso , Brazil., França EL; a Institute of Biological and Health Science, Federal University of Mato Grosso , Barra do Garças , Mato Grosso , Brazil., Honorio-França AC; a Institute of Biological and Health Science, Federal University of Mato Grosso , Barra do Garças , Mato Grosso , Brazil.
المصدر: Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2018 Feb; Vol. 40 (1), pp. 18-24. Date of Electronic Publication: 2017 Nov 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8800150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2513 (Electronic) Linking ISSN: 08923973 NLM ISO Abbreviation: Immunopharmacol Immunotoxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: New York, N.Y. : Marcel Dekker, c1987-
مواضيع طبية MeSH: Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Barium Compounds*/chemistry , Barium Compounds*/pharmacology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Chlorides*/chemistry , Chlorides*/pharmacology , Microspheres* , Polyethylene Glycols*/chemistry , Polyethylene Glycols*/pharmacology, Leukocytes, Mononuclear/*metabolism, Female ; Humans ; Leukocytes, Mononuclear/pathology ; MCF-7 Cells ; Male
مستخلص: This study investigated the effects of BaCl 2 adsorbed to polyethylene glycol (PEG) microspheres on human blood mononuclear cells (MN) co-cultured with breast cancer cell lines (MCF-7). The MCF-7 cells were obtained from the American Type Culture Collection and the blood mononuclear (MN) cells from volunteer donors. MN cells, MCF-7 cells and their co-culture (MN and MCF-7 cells) were pre-incubated for 24 h with or without 25 and 1000 pg L -1 BaCl 2 (Ba 25 and Ba 1000 ), PEG microspheres or 25 and 1000 pg L -1 BaCl 2 adsorbed to PEG microspheres (PEG-Ba 25 and PEG-Ba 1000 ). Rheological parameters and apoptosis were determined. Fluorescence microscopy and flow cytometry analyses revealed that BaCl 2 was able to adsorb the PEG microspheres. The blood flow and viscosity curves were similar among the treatments. In general, apoptosis rates increased in co-cultured cells, co-cultured cells incubated with Ba 25 and with PEG-Ba 25 , but the highest rates were observed in co-cultured cells incubated with PEG-Ba 1000 . In conclusion, BaCl 2 adsorbed to PEG microspheres exhibited dose-dependent antitumor effects against human MCF-7 breast cancer cells co-cultured with MN cells, thereby offering a possible therapeutic alternative for treating this disease provided they are administered at very low concentrations.
فهرسة مساهمة: Keywords: MCF-7 cells; PEG microsphere; apoptosis; barium chloride; mononuclear cells
المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Barium Compounds)
0 (Chlorides)
0VK51DA1T2 (barium chloride)
3WJQ0SDW1A (Polyethylene Glycols)
تواريخ الأحداث: Date Created: 20171103 Date Completed: 20180807 Latest Revision: 20181202
رمز التحديث: 20221213
DOI: 10.1080/08923973.2017.1392563
PMID: 29094617
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-2513
DOI:10.1080/08923973.2017.1392563