دورية أكاديمية
أعرض في EDS

Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression.

التفاصيل البيبلوغرافية
العنوان: Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression.
المؤلفون: Stamatiades GA; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States., Kaiser UB; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States. Electronic address: ukaiser@bwh.harvard.edu.
المصدر: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2018 Mar 05; Vol. 463, pp. 131-141. Date of Electronic Publication: 2017 Nov 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: North Holland Publishing Country of Publication: Ireland NLM ID: 7500844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8057 (Electronic) Linking ISSN: 03037207 NLM ISO Abbreviation: Mol Cell Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : North Holland Publishing
Original Publication: Amsterdam, North-Holland.
مواضيع طبية MeSH: Gene Expression Regulation* , Signal Transduction*, Gonadotropin-Releasing Hormone/*metabolism , Gonadotropins/*genetics, Animals ; Gonadotropins/metabolism ; Humans ; Models, Animal ; Receptors, LHRH/metabolism
مستخلص: The precise orchestration of hormonal regulation at all levels of the hypothalamic-pituitary-gonadal axis is essential for normal reproductive function and fertility. The pulsatile secretion of hypothalamic gonadotropin-releasing hormone (GnRH) stimulates the synthesis and release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by pituitary gonadotropes. GnRH acts by binding to its high affinity seven-transmembrane receptor (GnRHR) on the cell surface of anterior pituitary gonadotropes. Different signaling cascades and transcriptional mechanisms are activated, depending on the variation in GnRH pulse frequency, to stimulate the synthesis and release of FSH and LH. While changes in GnRH pulse frequency may explain some of the differential regulation of FSH and LH, other factors, such as activin, inhibin and sex steroids, also contribute to gonadotropin production. In this review, we focus on the transcriptional regulation of the gonadotropin subunit genes and the signaling pathways activated by pulsatile GnRH.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: R01 HD019938 United States HD NICHD NIH HHS; R37 HD019938 United States HD NICHD NIH HHS; T32 DK007529 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Follicle-stimulating hormone; G proteins; GnRH receptor; Gonadotropin-releasing hormone; Luteinizing hormone; Signal transduction
المشرفين على المادة: 0 (Gonadotropins)
0 (Receptors, LHRH)
33515-09-2 (Gonadotropin-Releasing Hormone)
تواريخ الأحداث: Date Created: 20171106 Date Completed: 20190225 Latest Revision: 20240814
رمز التحديث: 20240814
مُعرف محوري في PubMed: PMC5812824
DOI: 10.1016/j.mce.2017.10.015
PMID: 29102564
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-8057
DOI:10.1016/j.mce.2017.10.015