دورية أكاديمية
أعرض في EDS

Histological liver chances in Swiss mice caused by tannery effluent.

التفاصيل البيبلوغرافية
العنوان: Histological liver chances in Swiss mice caused by tannery effluent.
المؤلفون: Rabelo LM; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano-Campus Urutaí, Urutaí, GO, Brazil., Guimarães ATB; Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, CEP: 75790-000, Brazil., de Souza JM; Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, CEP: 75790-000, Brazil., da Silva WAM; Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, CEP: 75790-000, Brazil., de Oliveira Mendes B; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano-Campus Urutaí, Urutaí, GO, Brazil., de Oliveira Ferreira R; Laboratório de Pesquisas Biológicas, Instituto Federal Goiano-Campus Urutaí, Urutaí, GO, Brazil., de Lima Rodrigues AS; Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, CEP: 75790-000, Brazil., Malafaia G; Programa de Pós-Graduação em Conservação de Recursos Naturais do Cerrado, Instituto Federal Goiano-Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona Rural, Urutaí, GO, CEP: 75790-000, Brazil. guilhermeifgoiano@gmail.com.; Programa de Pós-Graduação em Biodiversidade Animal, Universidade Federal de Goiás-Campus Samambaia, Goiânia, GO, Brazil. guilhermeifgoiano@gmail.com.
المصدر: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2018 Jan; Vol. 25 (2), pp. 1943-1949. Date of Electronic Publication: 2017 Nov 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
أسماء مطبوعة: Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
مواضيع طبية MeSH: Tanning*, Hepatocytes/*drug effects , Industrial Waste/*adverse effects , Liver/*drug effects , Liver/*pathology , Water Pollutants, Chemical/*toxicity, Animals ; Female ; Hepatocytes/pathology ; Industrial Waste/analysis ; Male ; Mice ; Mice, Inbred C57BL ; Water Pollutants, Chemical/analysis
مستخلص: Although tannery effluents are known for being highly toxic to organisms, reports about the effects of the intake of these xenobiotics on experimental mammal models are recent. Studies about the damages the chronic intake of these effluents can cause in the liver of outbred mice remain an unexplored field. Thus, the aim of the present study is to assess (histological) the hepatic condition of Swiss mice (outbred strain) chronically exposed to the intake of different raw tannery effluent concentrations diluted in water for 150 days. Accordingly, the mice (males and females) were divided in the following groups: control group-animals treated with drinking water, only; and groups 5 and 10%-treated with raw tannery effluent diluted in water. After exposure, the animals were subjected to euthanasia for liver fragment sample collection and histological analysis, respectively. Moderate hydropic degeneration was observed in the centrilobular regions of the liver of mice exposed to 5 and 10% tannery effluent, as well as greater amounts of hepatocytes presenting karyomegaly and necrotic hepatocytes, and a smaller amount of Kuffer cells in the liver of mice exposed to the xenobiotic. Finally, animals exposed to 10% tannery effluent showed mild hyperplasia of the bile ducts in the portal areas and fibroblast proliferation around the bile ducts, thus suggesting a fibrous process. Except for the frequency of hepatocytes presenting karyomegaly (lower in females), the herein observed hepatic changes were similar in male and female Swiss mice. Accordingly, the present data support the hypothesis that the chronic intake of tannery effluent by outbred mice (Swiss) causes damages in the liver, a fact that broadens the knowledge about the toxic potential of this pollutant, which goes beyond that of C57Bl/6J male mice (inbred strain).
التعليقات: Erratum in: Environ Sci Pollut Res Int. 2018 Mar 27;:. (PMID: 29589236)
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معلومات مُعتمدة: 467801/2014-2 Brazilian National Council for Research (CNPq)
فهرسة مساهمة: Keywords: Animal model; Histopathology; Tannery wastewater; Toxicity; Xenobiotics
المشرفين على المادة: 0 (Industrial Waste)
0 (Water Pollutants, Chemical)
تواريخ الأحداث: Date Created: 20171106 Date Completed: 20181031 Latest Revision: 20181113
رمز التحديث: 20231215
DOI: 10.1007/s11356-017-0647-1
PMID: 29103125
قاعدة البيانات: MEDLINE
الوصف
تدمد:1614-7499
DOI:10.1007/s11356-017-0647-1