Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites.

التفاصيل البيبلوغرافية
العنوان:	Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites.
المؤلفون:	Ribeiro AJM; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Holliday GL; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Furnham N; Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 1HT, UK., Tyzack JD; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Ferris K; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Thornton JM; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
المصدر:	Nucleic acids research [Nucleic Acids Res] 2018 Jan 04; Vol. 46 (D1), pp. D618-D623.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res
أسماء مطبوعة:	Publication: 1992- : Oxford : Oxford University Press Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH:	Databases, Protein, Enzymes/chemistry , Enzymes/*metabolism, Biocatalysis ; Catalytic Domain ; Data Curation ; Humans ; Internet ; User-Computer Interface ; Web Browser
مستخلص:	M-CSA (Mechanism and Catalytic Site Atlas) is a database of enzyme active sites and reaction mechanisms that can be accessed at www.ebi.ac.uk/thornton-srv/m-csa. Our objectives with M-CSA are to provide an open data resource for the community to browse known enzyme reaction mechanisms and catalytic sites, and to use the dataset to understand enzyme function and evolution. M-CSA results from the merging of two existing databases, MACiE (Mechanism, Annotation and Classification in Enzymes), a database of enzyme mechanisms, and CSA (Catalytic Site Atlas), a database of catalytic sites of enzymes. We are releasing M-CSA as a new website and underlying database architecture. At the moment, M-CSA contains 961 entries, 423 of these with detailed mechanism information, and 538 with information on the catalytic site residues only. In total, these cover 81% (195/241) of third level EC numbers with a PDB structure, and 30% (840/2793) of fourth level EC numbers with a PDB structure, out of 6028 in total. By searching for close homologues, we are able to extend M-CSA coverage of PDB and UniProtKB to 51 993 structures and to over five million sequences, respectively, of which about 40% and 30% have a conserved active site. (© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.)
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معلومات مُعتمدة:	MR/K020420/1 United Kingdom MRC_ Medical Research Council
المشرفين على المادة:	0 (Enzymes)
تواريخ الأحداث:	Date Created: 20171107 Date Completed: 20190806 Latest Revision: 20220129
رمز التحديث:	20221213
مُعرف محوري في PubMed:	PMC5753290
DOI:	10.1093/nar/gkx1012
PMID:	29106569
قاعدة البيانات:	MEDLINE

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تدمد:	1362-4962
DOI:	10.1093/nar/gkx1012