دورية أكاديمية
Detection of cytomegalovirus, herpes virus simplex, and parvovirus b19 in spontaneous abortion placentas.
| العنوان: | Detection of cytomegalovirus, herpes virus simplex, and parvovirus b19 in spontaneous abortion placentas. |
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| المؤلفون: | Oliveira GM; a Departament of Pediatrics, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brasil., Pascoal-Xavier MA; b Departament of Pathology, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brasil., Moreira DR; b Departament of Pathology, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brasil., Guimarães VS; b Departament of Pathology, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brasil., Aguiar RALP; c Department Gynecology and Obstetrics, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brasil., Miranda DM; a Departament of Pediatrics, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brasil., Romanelli RMC; a Departament of Pediatrics, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brasil. |
| المصدر: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2019 Mar; Vol. 32 (5), pp. 768-775. Date of Electronic Publication: 2017 Nov 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002- |
| مواضيع طبية MeSH: | Abortion, Spontaneous/*virology , Cytomegalovirus/*isolation & purification , Parvovirus B19, Human/*isolation & purification , Placenta/*virology , Simplexvirus/*isolation & purification, Abortion, Spontaneous/pathology ; Adult ; Cross-Sectional Studies ; Female ; Humans ; Placenta/pathology ; Pregnancy ; Young Adult |
| مستخلص: | Objective: This study aims to investigate the presence of Cytomegalovirus (CMV), herpes virus simplex (HSV), and parvovirus B19 (PVB19) in the placental tissue of patients who underwent abortions without an otherwise-defined aetiology. Study Design: This cross-sectional study was conducted in a high-risk obstetric maternity facility at a University Hospital in Belo Horizonte, Brazil, from January 2013 to December 2015. We included placenta samples obtained from spontaneous abortions of unknown aetiology. Seventy placenta samples were identified and were classified according to histopathological characteristics. All samples were analysed using immunohistochemistry and polymerase chain reaction for CMV, PVB19, and HSV. The clinical variables were collected from the medical records of patients to verify the association of infection with villitis. The patients were divided into the following groups: I) with villitis (n = 28) and II) without villitis (n = 42). Methods: Immunohistochemistry used monoclonal anti-CMV antibody (NCL-CMVpp65, Leica Biosystems, Wetzlar, Germany), anti-PVB19 antibody (NCL-PARVO, Leica Biosystems, Wetzlar, Germany), and anti-HSV1/HSV2 antibodies (NCL-HSV-1 and HSV2, Leica Biosystems, Wetzlar, Germany). The data were analysed using the Statistical Package for Social Sciences (SPSS Inc, Chicago, IL) 19.0. Results: Viral agents were detected in five patients (7.14%) in the villitis group. Three patients were positive for CMV, one for PVB19, and one for HSV type 2. Foetal and maternal complications were significantly higher in the group with villitis compared with those in the group without villitis (p = .002). Conclusions: The prevalence of transplacental viral infections as a cause of spontaneous abortion should be considered high in the placenta with villitis. Thus, this study highlights the need for developing diagnostic tests to clarify the aetiology of abortion and foetal loss. |
| فهرسة مساهمة: | Keywords: cytomegalovirus; herpes virus simplex; parvovirus B19; spontaneous abortion; vertical transmission |
| تواريخ الأحداث: | Date Created: 20171109 Date Completed: 20191125 Latest Revision: 20191125 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/14767058.2017.1391778 |
| PMID: | 29113531 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-4954 |
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| DOI: | 10.1080/14767058.2017.1391778 |