دورية أكاديمية
أعرض في EDS

DNA polymerase η mutational signatures are found in a variety of different types of cancer.

التفاصيل البيبلوغرافية
العنوان: DNA polymerase η mutational signatures are found in a variety of different types of cancer.
المؤلفون: Rogozin IB; a National Center for Biotechnology Information, National Library of Medicine , National Institutes of Health , Bethesda , MD , USA., Goncearenco A; a National Center for Biotechnology Information, National Library of Medicine , National Institutes of Health , Bethesda , MD , USA., Lada AG; b Department Microbiology and Molecular Genetics , University of California , Davis , CA , USA., De S; c Rutgers Cancer Institute of New Jersey , Rutgers University , New Brunswick , NJ , USA., Yurchenko V; d Life Science Research Center , University of Ostrava, 71000 Ostrava , Czech Republic., Nudelman G; e Systems Biology Center , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , USA., Panchenko AR; a National Center for Biotechnology Information, National Library of Medicine , National Institutes of Health , Bethesda , MD , USA., Cooper DN; f Institute of Medical Genetics, School of Medicine , Cardiff University , UK., Pavlov YI; g Eppley Institute for Research in Cancer and Allied Diseases , University of Nebraska Medical Center , Omaha , NE 68198, USA.; h Departments of Microbiology and Pathology , University of Nebraska Medical Center , Omaha , NE , USA.; i Biochemistry and Molecular Biology , University of Nebraska Medical Center , Omaha , NE , USA.; j Genetics, Cell Biology and Anatomy , University of Nebraska Medical Center , Omaha , NE , USA.
المصدر: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2018; Vol. 17 (3), pp. 348-355. Date of Electronic Publication: 2018 Feb 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137841 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1551-4005 (Electronic) Linking ISSN: 15514005 NLM ISO Abbreviation: Cell Cycle Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Georgetown, TX : Landes Bioscience, c2002-
مواضيع طبية MeSH: DNA-Directed DNA Polymerase/*genetics , Mutation/*genetics , Neoplasms/*enzymology , Neoplasms/*genetics, Base Sequence ; Exome/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Skin/pathology ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology
مستخلص: DNA polymerase (pol) η is a specialized error-prone polymerase with at least two quite different and contrasting cellular roles: to mitigate the genetic consequences of solar UV irradiation, and promote somatic hypermutation in the variable regions of immunoglobulin genes. Misregulation and mistargeting of pol η can compromise genome integrity. We explored whether the mutational signature of pol η could be found in datasets of human somatic mutations derived from normal and cancer cells. A substantial excess of single and tandem somatic mutations within known pol η mutable motifs was noted in skin cancer as well as in many other types of human cancer, suggesting that somatic mutations in A:T bases generated by DNA polymerase η are a common feature of tumorigenesis. Another peculiarity of pol ηmutational signatures, mutations in YCG motifs, led us to speculate that error-prone DNA synthesis opposite methylated CpG dinucleotides by misregulated pol η in tumors might constitute an additional mechanism of cytosine demethylation in this hypermutable dinucleotide.
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معلومات مُعتمدة: P30 CA072720 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: DNA lesion bypass; Hypermutation; POLH; gene expression profiles; mutable motif; skin cancer; sloppy DNA polymerase
المشرفين على المادة: EC 2.7.7.7 (DNA-Directed DNA Polymerase)
EC 2.7.7.7 (Rad30 protein)
تواريخ الأحداث: Date Created: 20171116 Date Completed: 20190906 Latest Revision: 20201214
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5914734
DOI: 10.1080/15384101.2017.1404208
PMID: 29139326
قاعدة البيانات: MEDLINE
الوصف
تدمد:1551-4005
DOI:10.1080/15384101.2017.1404208