دورية أكاديمية
Flavonoidal Constituents, Antioxidant, Antimicrobial, and Cytotoxic Activities of Dipterygium glaucum Grown in Kingdom of Saudi Arabia.
العنوان: | Flavonoidal Constituents, Antioxidant, Antimicrobial, and Cytotoxic Activities of Dipterygium glaucum Grown in Kingdom of Saudi Arabia. |
---|---|
المؤلفون: | Shaheen U; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah Al Mukarramah 21955, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Shoeib NA; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah Al Mukarramah 21955, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt., Temraz A; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah Al Mukarramah 21955, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Abdelhady MIS; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah Al Mukarramah 21955, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt. |
المصدر: | Pharmacognosy magazine [Pharmacogn Mag] 2017 Oct; Vol. 13 (Suppl 3), pp. S484-S488. Date of Electronic Publication: 2017 Oct 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 101300403 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0973-1296 (Print) Linking ISSN: 09731296 NLM ISO Abbreviation: Pharmacogn Mag Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2023- : [Thousand Oaks] : SAGE Publications Original Publication: 2005-<2009> : Bangalore : Phcog.Net, Al-Ameen College of Pharmacy |
مستخلص: | Background: Dipterygium glaucum Decne. herb is one of the common traditional plants with multiple medicinal uses. Objective: To isolate the major constituents and to investigate the antioxidant, antimicrobial, and cytotoxic activities of this herb. Materials and Methods: Methanolic extract of D. glaucum herb was fractionated using n -hexane, dichloromethane, and n -butanol. Butanol fraction was chromatographed using column chromatography and preparative thin layer chromatography to isolate the major constituents. Isolated compounds were elucidated by means of spectroscopic methods, including 1D, 2D NMR ( 1 H, 13 C, DEPT, COSY, HSQC, HMBC, NEOSY) and MS analysis. Total phenolic content using Folin-Ciocalteu reagent and antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay of the total methanolic extract were evaluated. Cytotoxic potential of both methanolic extract and butanol fraction was tested using a crystal violet viability assay. Antimicrobial activities of both extracts were investigated using diffusion agar technique. Results: Apigenin 6, 8-di-C-glucopyranoside (vicenin-2), quercetin-3`- O -methyl-3- O -glucopyranoside, quercetin-3`- O -methyl-3- O -galactopyranoside, quercetin-3- O - β -D-glucopyranoside, and quercetin-3- O - β -D-galactopyranoside were isolated and elucidated. Total phenolic content was (83.89 mg gallic acid equivalent/g extract). The EC Conclusion: Data obtained from this study demonstrate that D. glaucum possesses significant antioxidant, cytotoxic, and antimicrobial activities which could be ascribed to its flavonoidal content. Summary: Dipterygium glaucum Decne. herb is one of the common traditional plants with multiple medicinal uses in KSAFive flvonidal glycosides were isolated and elucidatedThis study demonstrated that D. glaucum possesses significant antioxidant, cytotoxic, and antimicrobial activities. Abbreviations used: KSA: Kingdom of Saudi Arabia; TLC: Thin Layer Chromatography; DPPH: 2,2`-diphenyl-1-picrylhydrazyl; EC50: Half maximal effective concentration; IC Competing Interests: There are no conflicts of interest. |
References: | BMC Complement Altern Med. 2015 Nov 27;15(1):422. (PMID: 26613959) Arch Toxicol. 2012 Mar;86(3):345-91. (PMID: 22102161) Biomol Ther (Seoul). 2012 Jul;20(4):406-12. (PMID: 24009828) Phytochemistry. 2000 Oct;55(3):263-7. (PMID: 11142853) Int J Mol Sci. 2014 Dec 04;15(12):22483-91. (PMID: 25486059) Biochem Pharmacol. 2011 Nov 1;82(9):1100-9. (PMID: 21803027) Am J Clin Pathol. 1966 Apr;45(4):493-6. (PMID: 5325707) Mem Inst Oswaldo Cruz. 2000 May-Jun;95(3):367-73. (PMID: 10800195) Molecules. 2010 Nov 05;15(11):7933-45. (PMID: 21060300) J Immunol Methods. 1983 Dec 16;65(1-2):55-63. (PMID: 6606682) Fitoterapia. 2004 Mar;75(2):149-61. (PMID: 15030919) Cancer Lett. 2008 Nov 8;270(2):342-53. (PMID: 18617322) Pharmacogn Rev. 2010 Jul;4(8):118-26. (PMID: 22228951) Evid Based Complement Alternat Med. 2013;2013:617459. (PMID: 24367388) J Agric Food Chem. 2002 Jan 2;50(1):81-6. (PMID: 11754547) Nutr Rev. 1998 Nov;56(11):317-33. (PMID: 9838798) Molecules. 2012 Apr 17;17 (4):4595-603. (PMID: 22510608) Evid Based Complement Alternat Med. 2010 Sep;7(3):323-30. (PMID: 18955315) |
فهرسة مساهمة: | Keywords: Antimicrobial; Dipterygium glaucum; antioxidant; cytotoxic; flavonoids |
تواريخ الأحداث: | Date Created: 20171117 Latest Revision: 20220310 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5669086 |
DOI: | 10.4103/pm.pm_44_16 |
PMID: | 29142403 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0973-1296 |
---|---|
DOI: | 10.4103/pm.pm_44_16 |