دورية أكاديمية
أعرض في EDS

White matter abnormalities in 22q11.2 deletion syndrome patients showing cognitive decline.

التفاصيل البيبلوغرافية
العنوان: White matter abnormalities in 22q11.2 deletion syndrome patients showing cognitive decline.
المؤلفون: Nuninga JO; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands., Bohlken MM; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands., Koops S; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands., Fiksinski AM; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands., Mandl RCW; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands., Breetvelt EJ; Dalglish Family Hearts and Minds Clinic for 22q11.2 Deletion Syndrome, Toronto General Hospital, University Health Network,Toronto, Ontario,Canada., Duijff SN; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands., Kahn RS; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands., Sommer IEC; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands., Vorstman JAS; Department of Psychiatry,Rudolf Magnus Institute of Neuroscience, University Medical Center,Utrecht,The Netherlands.
المصدر: Psychological medicine [Psychol Med] 2018 Jul; Vol. 48 (10), pp. 1655-1663. Date of Electronic Publication: 2017 Nov 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cambridge University Press Country of Publication: England NLM ID: 1254142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8978 (Electronic) Linking ISSN: 00332917 NLM ISO Abbreviation: Psychol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Cambridge University Press
Original Publication: London, British Medical Assn.
مواضيع طبية MeSH: Cognitive Dysfunction*/diagnostic imaging , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/pathology , Cognitive Dysfunction*/physiopathology , DiGeorge Syndrome*/complications , DiGeorge Syndrome*/diagnostic imaging , DiGeorge Syndrome*/pathology , DiGeorge Syndrome*/physiopathology , Psychotic Disorders*/diagnostic imaging , Psychotic Disorders*/etiology , Psychotic Disorders*/pathology , Psychotic Disorders*/physiopathology, White Matter/*pathology, Adolescent ; Adult ; Child ; Cohort Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; White Matter/diagnostic imaging ; Young Adult
مستخلص: Background: Decline in cognitive functioning precedes the first psychotic episode in the course of schizophrenia and is considered a hallmark symptom of the disorder. Given the low incidence of schizophrenia, it remains a challenge to investigate whether cognitive decline coincides with disease-related changes in brain structure, such as white matter abnormalities. The 22q11.2 deletion syndrome (22q11DS) is an appealing model in this context, as 25% of patients develop psychosis. Furthermore, we recently showed that cognitive decline also precedes the onset of psychosis in individuals with 22q11DS. Here, we investigate whether the early cognitive decline in patients with 22q11DS is associated with alterations in white matter microstructure.
Methods: We compared the fractional anisotropy (FA) of white matter in 22q11DS patients with cognitive decline [n = 16; -18.34 (15.8) VIQ percentile points over 6.80 (2.39) years] to 22q11DS patients without cognitive decline [n = 18; 17.71 (20.17) VIQ percentile points over 5.27 (2.03) years] by applying an atlas-based approach to diffusion-weighted imaging data.
Results: FA was significantly increased (p < 0.05, FDR) in 22q11DS patients with a cognitive decline in the bilateral superior longitudinal fasciculus, the bilateral cingulum bundle, all subcomponents of the left internal capsule and the left superior frontal-occipital fasciculus as compared with 22q11DS patients without cognitive decline.
Conclusions: Within 22q11DS, the early cognitive decline is associated with microstructural differences in white matter. At the mean age of 17.8 years, these changes are reflected in increased FA in several tracts. We hypothesize that similar brain alterations associated with cognitive decline take place early in the trajectory of schizophrenia.
فهرسة مساهمة: Keywords: 22q11DS; DTI; intelligence; schizophrenia; white matter
تواريخ الأحداث: Date Created: 20171117 Date Completed: 20190412 Latest Revision: 20190412
رمز التحديث: 20240628
DOI: 10.1017/S0033291717003142
PMID: 29143717
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-8978
DOI:10.1017/S0033291717003142