دورية أكاديمية
Is there a role for combination anti-remodelling therapy for heart failure secondary to chronic rheumatic mitral regurgitation?
| العنوان: | Is there a role for combination anti-remodelling therapy for heart failure secondary to chronic rheumatic mitral regurgitation? |
|---|---|
| المؤلفون: | Meel R; Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa. Email: ruchikameel@gmail.com., Peters F; Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa., Libhaber E; Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa., Essop MR; Division of Cardiology, Chris Hani Baragwanath Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa. |
| المصدر: | Cardiovascular journal of Africa [Cardiovasc J Afr] 2017 Sep/Oct; Vol. 28 (5), pp. 280-284. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Clinics Cardive Pub Country of Publication: South Africa NLM ID: 101313864 Publication Model: Print Cited Medium: Internet ISSN: 1680-0745 (Electronic) Linking ISSN: 10159657 NLM ISO Abbreviation: Cardiovasc J Afr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Durbanville : Clinics Cardive Pub. |
| مواضيع طبية MeSH: | Heart Failure/*drug therapy , Mitral Valve Insufficiency/*physiopathology , Ventricular Function, Left/*drug effects , Ventricular Remodeling/*drug effects, Adult ; Aged ; Echocardiography/methods ; Female ; Heart Atria/drug effects ; Heart Atria/physiopathology ; Humans ; Male ; Middle Aged ; Mitral Valve Insufficiency/drug therapy ; Prospective Studies |
| مستخلص: | Introduction: The value of combination anti-remodelling therapy for heart failure (HF) secondary to mitral regurgitation (MR) is unknown. We studied the effect of anti-remodelling therapy on clinical and echocardiographic parameters in patients with severe chronic rheumatic mitral regurgitation (CRMR) presenting in HF. Methods: Thirty-one patients (29 females) at Chris Hani Baragwanath Academic Hospital, treated with combination therapy for HF due to CRMR and New York Heart Association functional class II-III symptoms, underwent prospective six-month follow up. Results: Mean age was 50.7 ± 8.5 years. No patients died or were hospitalised for HF during the study period. No worsening of clinical symptoms or functional status, or left and right ventricular echocardiographic parameters (p > 0.05) was noted. Peak left atrial systolic strain improved at six months (18.7 ± 7.7 vs 23.6 ± 8.5%, p = 0.02). Conclusion: This preliminary analysis suggests that combination anti-remodelling therapy may be beneficial for HF secondary to CRMR. We had no HF-related admissions or deaths, and no deterioration in echocardiographic parameters of ventricular size and function. |
| References: | Circ Heart Fail. 2013 Jul;6(4):624-6. (PMID: 23861504) Circulation. 2012 Jul 24;126(4):501-6. (PMID: 22825412) Circulation. 1957 Nov;16(5):700-12. (PMID: 13473042) Eur Heart J Cardiovasc Imaging. 2013 Jul;14 (7):611-44. (PMID: 23733442) J Am Coll Cardiol. 2012 Aug 28;60(9):833-8. (PMID: 22818065) J Am Coll Cardiol. 1999 Dec;34(7):2078-85. (PMID: 10588227) J Am Coll Cardiol. 2000 Mar 1;35(3):569-82. (PMID: 10716457) Eur Heart J. 2007 Nov;28(21):2627-36. (PMID: 17526904) Am J Cardiol. 2006 Apr 15;97(8):1213-9. (PMID: 16616028) J Am Soc Echocardiogr. 2010 Jul;23 (7):685-713; quiz 786-8. (PMID: 20620859) PLoS One. 2012;7(6):e40110. (PMID: 22768235) Circulation. 1995 Feb 15;91(4):1022-8. (PMID: 7850937) J Clin Invest. 1994 Jun;93(6):2639-48. (PMID: 7911128) Congest Heart Fail. 2013 May-Jun;19(3):107-15. (PMID: 23241032) Eur J Echocardiogr. 2009 Mar;10 (2):165-93. (PMID: 19270053) J Am Coll Cardiol. 2009 Nov 17;54(21):1961-8. (PMID: 19909877) JACC Cardiovasc Imaging. 2008 Mar;1(2):133-41. (PMID: 19356418) Am J Cardiol. 1975 Feb;35(2):234-42. (PMID: 1119383) Nat Rev Cardiol. 2012 Feb 28;9(5):297-309. (PMID: 22371105) Eur J Heart Fail. 2012 Aug;14(8):803-69. (PMID: 22828712) Tex Heart Inst J. 1986 Dec;13(4):453-7. (PMID: 15227354) Rev Esp Cardiol (Engl Ed). 2014 Aug;67(8):651-8. (PMID: 25037544) J Am Soc Echocardiogr. 2009 Mar;22(3):299-305. (PMID: 19258177) J Am Coll Cardiol. 2008 Jan 1;51(1):1-11. (PMID: 18174029) J Am Coll Cardiol. 2011 Mar 29;57(13):1468-76. (PMID: 21435516) Tex Heart Inst J. 2015 Feb 01;42(1):87-9. (PMID: 25873810) Circulation. 2013 Oct 15;128(16):e240-327. (PMID: 23741058) Indian Heart J. 2014 Mar-Apr;66(2):176-82. (PMID: 24814111) Circulation. 2006 May 9;113(18):2238-44. (PMID: 16651470) Circulation. 1960 Jul;22:39-48. (PMID: 14407272) J Am Coll Cardiol. 2014 Jun 10;63(22):e57-185. (PMID: 24603191) J Am Coll Cardiol. 2002 Jul 17;40(2):304-10. (PMID: 12106936) Cardiovasc Ultrasound. 2009 Feb 08;7:6. (PMID: 19200402) J Am Coll Cardiol. 2008 Jul 29;52(5):319-26. (PMID: 18652937) N Engl J Med. 2005 Mar 3;352(9):875-83. (PMID: 15745978) Circulation. 2008 Nov 25;118(22):2298-303. (PMID: 19029478) J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14. (PMID: 25559473) Am J Cardiol. 1987 Aug 1;60(4):397-9. (PMID: 3618505) J Am Coll Cardiol. 2012 Aug 28;60(9):839-40. (PMID: 22818062) Circulation. 1999 Jan 26;99(3):400-5. (PMID: 9918527) Eur J Echocardiogr. 2010 May;11(4):307-32. (PMID: 20435783) Eur J Echocardiogr. 2009 Oct;10 (7):833-40. (PMID: 19531539) Am Heart J. 1969 Sep;78(3):406-18. (PMID: 4241075) Rev Esp Cardiol. 2007 Mar;60(3):223-7. (PMID: 17394865) |
| تواريخ الأحداث: | Date Created: 20171117 Date Completed: 20180726 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5730678 |
| DOI: | 10.5830/CVJA-2016-095 |
| PMID: | 29144532 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1680-0745 |
|---|---|
| DOI: | 10.5830/CVJA-2016-095 |