دورية أكاديمية
أعرض في EDS

Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD.

التفاصيل البيبلوغرافية
العنوان: Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD.
المؤلفون: Cortese BM; Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, SC, USA. Electronic address: corteseb@musc.edu., Schumann AY; Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, SC, USA., Howell AN; Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, SC, USA., McConnell PA; Department of Neurosciences, MUSC, Charleston, SC, USA., Yang QX; Department of Radiology, Penn State Hershey Medical Center, Hershey, PA, USA., Uhde TW; Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, SC, USA.
المصدر: NeuroImage. Clinical [Neuroimage Clin] 2017 Sep 28; Vol. 17, pp. 378-387. Date of Electronic Publication: 2017 Sep 28 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101597070 Publication Model: eCollection Cited Medium: Internet ISSN: 2213-1582 (Electronic) Linking ISSN: 22131582 NLM ISO Abbreviation: Neuroimage Clin Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier
مواضيع طبية MeSH: Smell*, Brain/*physiopathology , Olfactory Perception/*physiology , Stress Disorders, Post-Traumatic/*physiopathology , Stress Disorders, Post-Traumatic/*psychology , Trigeminal Nerve/*physiopathology, Adult ; Brain Mapping ; Combat Disorders/physiopathology ; Combat Disorders/psychology ; Female ; Humans ; Magnetic Resonance Angiography ; Male ; Odorants ; Olfactory Pathways ; Sensory Thresholds ; Veterans
مستخلص: Structural and functional changes in the olfactory system are increasingly implicated in the expression of PTSD. Still, very little is known about the neurobiological networks of trauma-related odor sensitivity or how they relate to other objective and subjective measures of olfaction and PTSD. The purpose of this study was to replicate prior findings and further characterize olfactory function in trauma-exposed combat veterans with and without PTSD. We also sought to extend this area of research by exploring the effects of time since the combat-related index trauma (TST) on post-trauma olfactory function, as well as by correlating odor-elicited brain activity to general olfactory ability and odor-elicited PTSD symptoms. Participants included combat veterans with PTSD (CV+PTSD; n  = 21) or without any psychiatric disorder (CV-PTSD; n  = 27). TST was coded as greater ( n  = 24) or less (n = 24) than 5 years. There were main effects and/or interaction for PTSD-status and TST across several parameters of olfactory function: odor detection, odor identification, ratings for trauma-related odor intensity and triggered PTSD symptoms, and trauma odor-elicited brain activation. Overall, results suggest olfactory impairment in chronic PTSD, but not necessarily in the earlier stages of the disorder, although some early-stage olfactory findings may be predictive of later olfactory impairment. Results also suggest that trauma-exposed individuals who never develop PTSD may demonstrate olfactory resiliency. Finally, results highlight a potentially unique role of trigeminal odor properties in the olfactory-PTSD relationship.
References: J Neural Transm (Vienna). 2013 Jan;120(1):121-30. (PMID: 22806003)
Electroencephalogr Clin Neurophysiol. 1988 Jul-Aug;71(4):241-50. (PMID: 2454788)
Chem Senses. 2013 Sep;38(7):577-84. (PMID: 23811013)
Psychiatry Clin Neurosci. 2015 Jul;69(7):431-8. (PMID: 25605415)
Eur Neuropsychopharmacol. 1999 Sep;9(5):415-20. (PMID: 10523048)
PLoS One. 2016 Dec 9;11(12):e0168006. (PMID: 27936122)
Gen Hosp Psychiatry. 2004 Sep-Oct;26(5):390-7. (PMID: 15474639)
Int J Psychophysiol. 2010 Mar;75(3):326-31. (PMID: 20079770)
PLoS One. 2013 Sep 24;8(9):e74655. (PMID: 24086358)
Physiol Behav. 1984 Mar;32(3):489-502. (PMID: 6463130)
Neuroreport. 2016 May 4;27(7):527-31. (PMID: 27031873)
J Clin Psychiatry. 1985 Sep;46(9):383-4. (PMID: 4030702)
Int Arch Occup Environ Health. 2002 Jun;75(5):305-13. (PMID: 11981669)
J Psychiatr Res. 2015 Nov;70:58-66. (PMID: 26424424)
Anxiety. 1994-1995;1(4):161-8. (PMID: 9160568)
Neuroimage. 2013 Feb 1;66:333-42. (PMID: 23103688)
Chemosens Percept. 2012 Mar 1;5(1):37-45. (PMID: 22866182)
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57. (PMID: 9881538)
Biol Psychiatry. 2011 Sep 1;70(5):415-24. (PMID: 21550590)
Regul Toxicol Pharmacol. 1996 Aug;24(1 Pt 2):S79-86. (PMID: 8921561)
C R Biol. 2004 Apr;327(4):305-11. (PMID: 15212362)
Nord J Psychiatry. 2005;59(1):39-44. (PMID: 16195097)
Brain Res Rev. 2010 Mar;62(2):183-96. (PMID: 19913573)
Biol Psychol. 2013 Feb;92(2):135-41. (PMID: 23174695)
Physiol Behav. 1978 Feb;20(2):175-85. (PMID: 662939)
Int J Psychophysiol. 2009 Nov;74(2):88-92. (PMID: 19666058)
J Affect Disord. 2015 Jul 1;179:23-30. (PMID: 25845746)
J Neurosci. 2007 Sep 12;27(37):10015-23. (PMID: 17855616)
Psychopharmacol Bull. 2007;40(1):8-30. (PMID: 17285093)
Ann Fam Med. 2012 Jul-Aug;10(4):357-65. (PMID: 22778124)
J Clin Psychiatry. 2003 Feb;64(2):202-7. (PMID: 12633130)
Clin Neurophysiol. 2007 Mar;118(3):696-701. (PMID: 17208517)
Depress Anxiety. 2012 Apr;29(4):264-81. (PMID: 22511362)
Sens Processes. 1976 Jun;1(1):57-67. (PMID: 1029077)
Curr Opin Neurobiol. 2002 Aug;12(4):455-61. (PMID: 12139995)
Neuroimage. 2013 Aug 15;77:93-104. (PMID: 23558094)
J Psychiatry Neurosci. 1996 Nov;21(5):340-2. (PMID: 8973054)
Psychiatry Res Neuroimaging. 2017 Apr 30;262:15-24. (PMID: 28208068)
Neuron. 2012 Feb 23;73(4):653-76. (PMID: 22365542)
Electroencephalogr Clin Neurophysiol. 1992 Mar-Apr;84(2):192-5. (PMID: 1372235)
Psychol Med. 2008 Apr;38(4):523-31. (PMID: 17903334)
Science. 2013 Dec 13;342(6164):1389-1392. (PMID: 24337299)
Science. 2008 Mar 28;319(5871):1842-5. (PMID: 18369149)
Depress Anxiety. 2011 Oct 3;28(10):932-40. (PMID: 21618671)
Biol Psychiatry. 2010 Feb 15;67(4):346-56. (PMID: 19875104)
Clin Neurol Neurosurg. 2016 Jan;140:68-72. (PMID: 26658033)
Toxicol Ind Health. 1994 Jul-Oct;10(4-5):359-68. (PMID: 7539950)
J Affect Disord. 2015 Apr 1;175:292-8. (PMID: 25661394)
Am J Psychiatry. 2007 Oct;164(10):1476-88. (PMID: 17898336)
Mem Cognit. 2002 Jun;30(4):511-8. (PMID: 12184552)
Neuroreport. 2000 Aug 21;11(12):2711-6. (PMID: 10976949)
Am J Psychiatry. 1991 Dec;148(12):1757. (PMID: 1957949)
J Trauma Stress. 2000 Apr;13(2):241-53. (PMID: 10838673)
Biol Psychiatry. 1996 Mar 1;39(5):326-31. (PMID: 8704063)
J Clin Psychiatry. 1995 Apr;56(4):151-60. (PMID: 7713854)
Int J Psychophysiol. 2000 May;36(2):165-81. (PMID: 10742571)
J Neurosci. 2008 Dec 3;28(49):13106-11. (PMID: 19052201)
J Trauma Stress. 1995 Jan;8(1):75-90. (PMID: 7712061)
Neurosci Biobehav Rev. 2008 Sep;32(7):1315-25. (PMID: 18555528)
Biol Psychiatry. 1997 Oct 15;42(8):721-32. (PMID: 9325566)
Psychol Med. 2002 Nov;32(8):1387-94. (PMID: 12455937)
Neurology. 2015 Apr 14;84(15):1559-67. (PMID: 25788559)
معلومات مُعتمدة: K01 MH090548 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: Odor-threat; Olfaction; PTSD; Trigeminal; fMRI
تواريخ الأحداث: Date Created: 20171122 Date Completed: 20180629 Latest Revision: 20210109
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5683811
DOI: 10.1016/j.nicl.2017.09.018
PMID: 29159050
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-1582
DOI:10.1016/j.nicl.2017.09.018