دورية أكاديمية
Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD.
العنوان: | Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD. |
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المؤلفون: | Cortese BM; Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, SC, USA. Electronic address: corteseb@musc.edu., Schumann AY; Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, SC, USA., Howell AN; Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, SC, USA., McConnell PA; Department of Neurosciences, MUSC, Charleston, SC, USA., Yang QX; Department of Radiology, Penn State Hershey Medical Center, Hershey, PA, USA., Uhde TW; Department of Psychiatry and Behavioral Sciences, MUSC, Charleston, SC, USA. |
المصدر: | NeuroImage. Clinical [Neuroimage Clin] 2017 Sep 28; Vol. 17, pp. 378-387. Date of Electronic Publication: 2017 Sep 28 (Print Publication: 2018). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101597070 Publication Model: eCollection Cited Medium: Internet ISSN: 2213-1582 (Electronic) Linking ISSN: 22131582 NLM ISO Abbreviation: Neuroimage Clin Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier |
مواضيع طبية MeSH: | Smell*, Brain/*physiopathology , Olfactory Perception/*physiology , Stress Disorders, Post-Traumatic/*physiopathology , Stress Disorders, Post-Traumatic/*psychology , Trigeminal Nerve/*physiopathology, Adult ; Brain Mapping ; Combat Disorders/physiopathology ; Combat Disorders/psychology ; Female ; Humans ; Magnetic Resonance Angiography ; Male ; Odorants ; Olfactory Pathways ; Sensory Thresholds ; Veterans |
مستخلص: | Structural and functional changes in the olfactory system are increasingly implicated in the expression of PTSD. Still, very little is known about the neurobiological networks of trauma-related odor sensitivity or how they relate to other objective and subjective measures of olfaction and PTSD. The purpose of this study was to replicate prior findings and further characterize olfactory function in trauma-exposed combat veterans with and without PTSD. We also sought to extend this area of research by exploring the effects of time since the combat-related index trauma (TST) on post-trauma olfactory function, as well as by correlating odor-elicited brain activity to general olfactory ability and odor-elicited PTSD symptoms. Participants included combat veterans with PTSD (CV+PTSD; n = 21) or without any psychiatric disorder (CV-PTSD; n = 27). TST was coded as greater ( n = 24) or less (n = 24) than 5 years. There were main effects and/or interaction for PTSD-status and TST across several parameters of olfactory function: odor detection, odor identification, ratings for trauma-related odor intensity and triggered PTSD symptoms, and trauma odor-elicited brain activation. Overall, results suggest olfactory impairment in chronic PTSD, but not necessarily in the earlier stages of the disorder, although some early-stage olfactory findings may be predictive of later olfactory impairment. Results also suggest that trauma-exposed individuals who never develop PTSD may demonstrate olfactory resiliency. Finally, results highlight a potentially unique role of trigeminal odor properties in the olfactory-PTSD relationship. |
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معلومات مُعتمدة: | K01 MH090548 United States MH NIMH NIH HHS |
فهرسة مساهمة: | Keywords: Odor-threat; Olfaction; PTSD; Trigeminal; fMRI |
تواريخ الأحداث: | Date Created: 20171122 Date Completed: 20180629 Latest Revision: 20210109 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5683811 |
DOI: | 10.1016/j.nicl.2017.09.018 |
PMID: | 29159050 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2213-1582 |
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DOI: | 10.1016/j.nicl.2017.09.018 |