دورية أكاديمية
Ivermectin susceptibility, sporontocidal effect, and inhibition of time to re-feed in the Amazonian malaria vector Anopheles darlingi.
العنوان: | Ivermectin susceptibility, sporontocidal effect, and inhibition of time to re-feed in the Amazonian malaria vector Anopheles darlingi. |
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المؤلفون: | Kobylinski KC; Department of Entomology, Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok, 10400, Thailand. kobylinskikevin@yahoo.com.; Entomology Branch, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, USA. kobylinskikevin@yahoo.com., Escobedo-Vargas KS; Department of Entomology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., López-Sifuentes VM; Department of Entomology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Durand S; Department of Parasitology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Smith ES; Department of Parasitology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Baldeviano GC; Department of Parasitology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Gerbasi RV; Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, 20910, USA., Ballard SB; Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Rm. W5515, Baltimore, MD, 21205, USA., Stoops CA; Department of Entomology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Vásquez GM; Department of Entomology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru. |
المصدر: | Malaria journal [Malar J] 2017 Nov 21; Vol. 16 (1), pp. 474. Date of Electronic Publication: 2017 Nov 21. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central, [2002- |
مواضيع طبية MeSH: | Anopheles/*drug effects , Insecticides/*pharmacology , Ivermectin/*pharmacology , Mosquito Vectors/*drug effects , Plasmodium vivax/*drug effects, Animals ; Anopheles/parasitology ; Anopheles/physiology ; Feeding Behavior/drug effects ; Female ; Mosquito Vectors/parasitology ; Mosquito Vectors/physiology ; Oocysts/drug effects ; Peru ; Plasmodium vivax/growth & development |
مستخلص: | Background: Outdoor malaria transmission hinders malaria elimination efforts in the Amazon region and novel vector control tools are needed. Ivermectin mass drug administration (MDA) to humans kills wild Anopheles, targets outdoor-feeding vectors, and can suppress malaria parasite transmission. Laboratory investigations were performed to determine ivermectin susceptibility, sporontocidal effect and inhibition of time to re-feed for the primary Amazonian malaria vector, Anopheles darlingi. Methods: To assess ivermectin susceptibility, various concentrations of ivermectin were mixed in human blood and fed to An. darlingi. Mosquito survival was monitored daily for 7 days and a non-linear mixed effects model with Probit analysis was used to calculate lethal concentrations of ivermectin that killed 50% (LC Results: Ivermectin significantly reduced An. darlingi survivorship: 7-day-LC Conclusions: Ivermectin is lethal to An. darlingi, modestly inhibits sporogony of P. vivax, and delays time to re-feed at concentrations found in humans up to 12 h post drug ingestion. The LC |
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معلومات مُعتمدة: | OPP1095931 Bill and Melinda Gates Foundation |
فهرسة مساهمة: | Keywords: Amazon; Anopheles darlingi; Ivermectin; Plasmodium vivax |
المشرفين على المادة: | 0 (Insecticides) 70288-86-7 (Ivermectin) |
تواريخ الأحداث: | Date Created: 20171123 Date Completed: 20180620 Latest Revision: 20181113 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5696779 |
DOI: | 10.1186/s12936-017-2125-0 |
PMID: | 29162101 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1475-2875 |
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DOI: | 10.1186/s12936-017-2125-0 |