دورية أكاديمية
أعرض في EDS

Ivermectin susceptibility, sporontocidal effect, and inhibition of time to re-feed in the Amazonian malaria vector Anopheles darlingi.

التفاصيل البيبلوغرافية
العنوان: Ivermectin susceptibility, sporontocidal effect, and inhibition of time to re-feed in the Amazonian malaria vector Anopheles darlingi.
المؤلفون: Kobylinski KC; Department of Entomology, Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok, 10400, Thailand. kobylinskikevin@yahoo.com.; Entomology Branch, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, USA. kobylinskikevin@yahoo.com., Escobedo-Vargas KS; Department of Entomology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., López-Sifuentes VM; Department of Entomology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Durand S; Department of Parasitology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Smith ES; Department of Parasitology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Baldeviano GC; Department of Parasitology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Gerbasi RV; Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, MD, 20910, USA., Ballard SB; Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Rm. W5515, Baltimore, MD, 21205, USA., Stoops CA; Department of Entomology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru., Vásquez GM; Department of Entomology, U.S. Naval Medical Research Unit No. 6, Av. Venezuela block 36 s/n, Callao 2, Peru.
المصدر: Malaria journal [Malar J] 2017 Nov 21; Vol. 16 (1), pp. 474. Date of Electronic Publication: 2017 Nov 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Anopheles/*drug effects , Insecticides/*pharmacology , Ivermectin/*pharmacology , Mosquito Vectors/*drug effects , Plasmodium vivax/*drug effects, Animals ; Anopheles/parasitology ; Anopheles/physiology ; Feeding Behavior/drug effects ; Female ; Mosquito Vectors/parasitology ; Mosquito Vectors/physiology ; Oocysts/drug effects ; Peru ; Plasmodium vivax/growth & development
مستخلص: Background: Outdoor malaria transmission hinders malaria elimination efforts in the Amazon region and novel vector control tools are needed. Ivermectin mass drug administration (MDA) to humans kills wild Anopheles, targets outdoor-feeding vectors, and can suppress malaria parasite transmission. Laboratory investigations were performed to determine ivermectin susceptibility, sporontocidal effect and inhibition of time to re-feed for the primary Amazonian malaria vector, Anopheles darlingi.
Methods: To assess ivermectin susceptibility, various concentrations of ivermectin were mixed in human blood and fed to An. darlingi. Mosquito survival was monitored daily for 7 days and a non-linear mixed effects model with Probit analysis was used to calculate lethal concentrations of ivermectin that killed 50% (LC 50 ), 25% (LC 25 ) and 5% (LC 5 ) of mosquitoes. To examine ivermectin sporonticidal effect, Plasmodium vivax blood samples were collected from malaria patients and offered to mosquitoes without or with ivermectin at the LC 50 , LC 25 or LC 5 . To assess ivermectin inhibition of mosquito time to re-feed, concentrations of ivermectin predicted to occur after a single oral dose of 200 μg/kg ivermectin were fed to An. darlingi. Every day for 12 days thereafter, individual mosquitoes were given the opportunity to re-feed on a volunteer. Any mosquitoes that re-blood fed or died were removed from the study.
Results: Ivermectin significantly reduced An. darlingi survivorship: 7-day-LC 50  = 43.2 ng/ml [37.5, 48.6], -LC 25  = 27.8 ng/ml [20.4, 32.9] and -LC 5  = 14.8 ng/ml [7.9, 20.2]. Ivermectin compound was sporontocidal to P. vivax in An. darlingi at the LC 50 and LC 25 concentrations reducing prevalence by 22.6 and 17.1%, respectively, but not at the LC 5 . Oocyst intensity was not altered at any concentration. Ivermectin significantly delayed time to re-feed at the 4-h (48.7 ng/ml) and 12-h (26.9 ng/ml) concentrations but not 36-h (10.6 ng/ml) or 60-h (6.3 ng/ml).
Conclusions: Ivermectin is lethal to An. darlingi, modestly inhibits sporogony of P. vivax, and delays time to re-feed at concentrations found in humans up to 12 h post drug ingestion. The LC 50 value suggests that a higher than standard dose (400-μg/kg) is necessary to target An. darlingi. These results suggest that ivermectin MDA has potential in the Amazon region to aid malaria elimination efforts.
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معلومات مُعتمدة: OPP1095931 Bill and Melinda Gates Foundation
فهرسة مساهمة: Keywords: Amazon; Anopheles darlingi; Ivermectin; Plasmodium vivax
المشرفين على المادة: 0 (Insecticides)
70288-86-7 (Ivermectin)
تواريخ الأحداث: Date Created: 20171123 Date Completed: 20180620 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5696779
DOI: 10.1186/s12936-017-2125-0
PMID: 29162101
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2875
DOI:10.1186/s12936-017-2125-0