دورية أكاديمية
أعرض في EDS

Network-level dysconnectivity in patients with nasopharyngeal carcinoma (NPC) early post-radiotherapy: longitudinal resting state fMRI study.

التفاصيل البيبلوغرافية
العنوان: Network-level dysconnectivity in patients with nasopharyngeal carcinoma (NPC) early post-radiotherapy: longitudinal resting state fMRI study.
المؤلفون: Qiu Y; Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510150, People's Republic of China. qiuyw1201@gmail.com., Guo Z; Department of Oncology, The First Affiliated Hospital of Ganzhou Medical University, Ganzhou, People's Republic of China., Han L; Department of Medical Imaging Centre, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China., Yang Y; Department of Medical Imaging Centre, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China., Li J; Department of Medical Imaging Centre, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China., Liu S; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China., Lv X; Department of Medical Imaging Centre, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China. lvxf@sysucc.org.cn.
المصدر: Brain imaging and behavior [Brain Imaging Behav] 2018 Oct; Vol. 12 (5), pp. 1279-1289.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101300405 Publication Model: Print Cited Medium: Internet ISSN: 1931-7565 (Electronic) Linking ISSN: 19317557 NLM ISO Abbreviation: Brain Imaging Behav Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Secaucus, NJ : Springer
مواضيع طبية MeSH: Brain/*physiopathology , Brain/*radiation effects , Nasopharyngeal Carcinoma/*physiopathology , Nasopharyngeal Carcinoma/*radiotherapy , Nasopharyngeal Neoplasms/*physiopathology , Nasopharyngeal Neoplasms/*radiotherapy, Adult ; Antineoplastic Agents/therapeutic use ; Brain/diagnostic imaging ; Brain Mapping ; Cerebrovascular Circulation ; Cognition/radiation effects ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nasopharyngeal Carcinoma/diagnostic imaging ; Nasopharyngeal Carcinoma/psychology ; Nasopharyngeal Neoplasms/diagnostic imaging ; Nasopharyngeal Neoplasms/psychology ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology ; Neural Pathways/radiation effects ; Oxygen/blood ; Prospective Studies ; Radiation Dosage ; Rest ; Treatment Outcome ; Young Adult
مستخلص: In this study, we seek to longitudinally investigate the network-level functional connectivity (FC) alternations and its association with irradiation dose and cognition changes in the early stage post radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients. We performed independent component analysis (ICA) of resting state blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) from 39 newly diagnosed NPC patients before receiving treatment (baseline), and 3 months post-RT. the default mode network (DMN), salience network (SN), and executive control network (ECN) were extracted with well-validated software (GIFT). Inter-network connectivity was assessed using the functional network connectivity (FNC) toolbox. The inter- and intra-network FC was compared between time points, and the z value of FC alternation was correlated with the RT dose value and cognitive changes. Compared with baseline, the FC of the left anterior cingulate cortex (ACC) within the DMN, and the right insular within the SN, significantly reduced 3 months post-RT, with greater effects at higher doses in the right insular. Bilateral ECN FC was also significantly lower 3 months post-RT compared to the baseline. Chemotherapy was not associated with inter- and intra- network FC change. We found intra- and inter-network FC disruption in NPC patients 3 months post-RT, with the right insular showing a dose-dependent effect. Thus, this network-level FC may serve as a potential biomarker of the RT-induced brain functional impairments, and provide valuable targets for further functional recovery treatment.
معلومات مُعتمدة: 81401399 Natural Scientific Foundation of China; 81201084 and 81560283 Natural Scientific Foundation of China; 20151BAB205049 Natural Scientific Foundation of Jiangxi Province; 15ykpy35 Fundamental Research Funds for the Central Universities; B2014162 Medical Scientific Research Foundation of Guangdong Province
فهرسة مساهمة: Keywords: Functional connectivity; Nasopharyngeal carcinoma; Network; Radiotherapy; Resting-state functional magnetic resonance imaging
المشرفين على المادة: 0 (Antineoplastic Agents)
S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20171123 Date Completed: 20190401 Latest Revision: 20190401
رمز التحديث: 20231215
DOI: 10.1007/s11682-017-9801-0
PMID: 29164505
قاعدة البيانات: MEDLINE
الوصف
تدمد:1931-7565
DOI:10.1007/s11682-017-9801-0