دورية أكاديمية
Human Herpesvirus 8 in Perinatally HIV-infected Children with Interstitial Lung Disease.
| العنوان: | Human Herpesvirus 8 in Perinatally HIV-infected Children with Interstitial Lung Disease. |
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| المؤلفون: | Scotta MC; Biomedical Research Institute, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil., Fabro AT; Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Machado PRL; Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Ramos SG; Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Cervi MC; Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., da Fonseca BAL; Clinics Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Motta F; Hospital da Criança Santo Antônio, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Negrini BVM; Federal University of São Carlos, São Carlos, São Paulo, Brazil. |
| المصدر: | Journal of tropical pediatrics [J Trop Pediatr] 2018 Oct 01; Vol. 64 (5), pp. 382-388. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8010948 Publication Model: Print Cited Medium: Internet ISSN: 1465-3664 (Electronic) Linking ISSN: 01426338 NLM ISO Abbreviation: J Trop Pediatr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] Oxford University Press. |
| مواضيع طبية MeSH: | HIV Infections/*complications , Herpesvirus 8, Human/*isolation & purification , Lung Diseases, Interstitial/*complications , Lung Diseases, Interstitial/*virology, Antibodies, Viral/blood ; Child ; Child, Preschool ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/complications ; DNA, Viral/genetics ; Female ; HIV Infections/immunology ; HIV Infections/virology ; Herpesviridae Infections/complications ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/immunology ; Humans ; Immunohistochemistry ; Infant ; Lung/virology ; Lung Diseases, Interstitial/immunology ; Polymerase Chain Reaction/methods |
| مستخلص: | Introduction: Human herpesvirus 8 (HHV-8) is associated with the pathogenesis of Kaposi Sarcoma and interstitial pneumonitis in adults. This study aims to evaluate association between HHV-8 and interstitial lung disease in HIV-infected children. Methods: HIV-infected children with interstitial pneumonitis underwent lung biopsies in a tertiary hospital and were investigated for HHV-8, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) using polymerase chain reaction (PCR) and immunohistochemistry in lung tissue. Peripheral blood PCR was also performed for HHV-8. Results: From six patients included, PCR for HHV-8 was positive in lung samples in four children and in peripheral blood in one. PCR for EBV and CMV and immunohistochemical study for HHV-8, EBV and CMV in lung were negative in all patients. Conclusion: No previous cases of HHV-8-associated interstitial pneumonitis was described in HIV-infected children. An immunological disorder and an infectious agent might influence development of the lymphoid interstitial pneumonitis. HHV-8 may be this infectious trigger. |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (DNA, Viral) |
| تواريخ الأحداث: | Date Created: 20171123 Date Completed: 20191007 Latest Revision: 20220410 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/tropej/fmx080 |
| PMID: | 29165615 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1465-3664 |
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| DOI: | 10.1093/tropej/fmx080 |