دورية أكاديمية
أعرض في EDS

Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain.

التفاصيل البيبلوغرافية
العنوان: Transgenerational Effects of Bisphenol A on Gene Expression and DNA Methylation of Imprinted Genes in Brain.
المؤلفون: Drobná Z; Center for Human Health and the Environment and Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina., Henriksen AD; Department of Integrated Science and Technology, MSC 4102, James Madison University, Harrisonburg, Virginia., Wolstenholme JT; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia., Montiel C; Center for Human Health and the Environment and Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina., Lambeth PS; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia., Shang S; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia., Harris EP; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia., Zhou C; Department of Comparative Biosciences, University of Illinois, Urbana, Illinois., Flaws JA; Department of Comparative Biosciences, University of Illinois, Urbana, Illinois., Adli M; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia., Rissman EF; Center for Human Health and the Environment and Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina.
المصدر: Endocrinology [Endocrinology] 2018 Jan 01; Vol. 159 (1), pp. 132-144.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2017- : New York : Oxford University Press
Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions,
مواضيع طبية MeSH: Benzhydryl Compounds/*toxicity , Brain/*drug effects , DNA Methylation/*drug effects , Endocrine Disruptors/*toxicity , Epigenesis, Genetic/*drug effects , Gene Expression Regulation, Developmental/*drug effects , Maternal Exposure/*adverse effects , Phenols/*toxicity, Animals ; Brain/metabolism ; Crosses, Genetic ; Female ; Fetal Development/drug effects ; Hypothalamus, Anterior/drug effects ; Hypothalamus, Anterior/metabolism ; Lactation ; Male ; Mice, Inbred Strains ; Neurons/drug effects ; Neurons/metabolism ; Pregnancy ; Preoptic Area/drug effects ; Preoptic Area/metabolism ; RNA, Long Noncoding/agonists ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Random Allocation ; Septal Nuclei/drug effects ; Septal Nuclei/metabolism ; Sex Characteristics
مستخلص: Bisphenol A (BPA) is a ubiquitous man-made endocrine disrupting compound (EDC). Developmental exposure to BPA changes behavioral and reproductive phenotypes, and these effects can last for generations. We exposed embryos to BPA, producing two lineages: controls and BPA exposed. In the third filial generation (F3), brain tissues containing the preoptic area, the bed nucleus of the stria terminalis, and the anterior hypothalamus were collected. RNA sequencing (RNA-seq) and subsequent data analyses revealed 50 differentially regulated genes in the brains of F3 juveniles from BPA vs control lineages. BPA exposure can lead to loss of imprinting, and one of the two imprinted genes in our data set, maternally expressed gene 3 (Meg3), has been associated with EDCs and neurobehavioral phenotypes. We used quantitative polymerase chain reaction to examine the two imprinted genes in our data set, Meg3 and microRNA-containing gene Mirg (residing in the same loci). Confirming the RNA-seq, Meg3 messenger RNA was higher in F3 brains from the BPA lineage than in control brains. This was true in brains from mice produced with two different BPA paradigms. Next, we used pyrosequencing to probe differentially methylated regions of Meg3. We found transgenerational effects of BPA on imprinted genes in brain. Given these results, and data on Meg3 methylation in humans, we suggest this gene may be a biomarker indicative of early life environmental perturbation.
(Copyright © 2018 Endocrine Society.)
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معلومات مُعتمدة: P01 ES022848 United States ES NIEHS NIH HHS; P30 ES025128 United States ES NIEHS NIH HHS; R01 ES022759 United States ES NIEHS NIH HHS; T32 CA009109 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Benzhydryl Compounds)
0 (Endocrine Disruptors)
0 (MEG3 non-coding RNA, mouse)
0 (Phenols)
0 (RNA, Long Noncoding)
MLT3645I99 (bisphenol A)
تواريخ الأحداث: Date Created: 20171123 Date Completed: 20180221 Latest Revision: 20190419
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5761590
DOI: 10.1210/en.2017-00730
PMID: 29165653
قاعدة البيانات: MEDLINE
الوصف
تدمد:1945-7170
DOI:10.1210/en.2017-00730