دورية أكاديمية
أعرض في EDS

Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells.

التفاصيل البيبلوغرافية
العنوان: Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells.
المؤلفون: Goel AJ; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rieder MK; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Arnold HH; Cell and Molecular Biology, Institute of Zoology, Technical University Braunschweig, 38106 Braunschweig, Germany., Radice GL; Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA., Krauss RS; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: robert.krauss@mssm.edu.
المصدر: Cell reports [Cell Rep] 2017 Nov 21; Vol. 21 (8), pp. 2236-2250.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Cadherins/*metabolism , Muscle, Skeletal/*cytology , Satellite Cells, Skeletal Muscle/*cytology , Stem Cells/*cytology, Animals ; Cell Division/physiology ; Cell Polarity/physiology ; Cell Proliferation/physiology ; Mice ; Regeneration/physiology ; Signal Transduction/physiology
مستخلص: Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and impaired regeneration. Here, we identify cadherin-mediated adhesion and signaling between muscle stem cells (satellite cells [SCs]) and their myofiber niche as a mechanism that orchestrates the quiescence-to-activation transition. Conditional removal of N-cadherin and M-cadherin in mice leads to a break in SC quiescence, with long-term expansion of a regeneration-proficient SC pool. These SCs have an incomplete disruption of the myofiber-SC adhesive junction and maintain niche residence and cell polarity, yet show properties of SCs in a state of transition from quiescence toward full activation. Among these is nuclear localization of β-catenin, which is necessary for this phenotype. Injury-induced perturbation of niche adhesive junctions is therefore a likely first step in the quiescence-to-activation transition.
(Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: P30 CA196521 United States CA NCI NIH HHS; R01 AR046207 United States AR NIAMS NIH HHS; R01 AR050403 United States AR NIAMS NIH HHS; R01 AR070231 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: cadherin; cell adhesion; muscle; niche; quiescence; regeneration; satellite cell; stem cell; β-catenin
المشرفين على المادة: 0 (Cadherins)
142845-03-2 (M-cadherin)
تواريخ الأحداث: Date Created: 20171123 Date Completed: 20180802 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5702939
DOI: 10.1016/j.celrep.2017.10.102
PMID: 29166613
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2017.10.102