دورية أكاديمية
أعرض في EDS

Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in Autoimmune Thyroid Disease.

التفاصيل البيبلوغرافية
العنوان: Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in Autoimmune Thyroid Disease.
المؤلفون: Ramgopal S; Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, India., Rathika C; Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, India., Padma MR; Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, India., Murali V; Texas Tech University Health Sciences Center, Lubbock, TX 79430, United States., Arun K; Endocrinology & Diabetology, Madurai Institute of Diabetes and Endocrine Practice and Research, Madurai 625001, India., Kamaludeen MN; Abban Hospital, Madurai 625020, India., Balakrishnan K; Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, India. Electronic address: immunobala@mkuniversity.org.
المصدر: Gene [Gene] 2018 Feb 05; Vol. 642, pp. 430-438. Date of Electronic Publication: 2017 Nov 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland, 1976-
مواضيع طبية MeSH: Polymorphism, Genetic*, CTLA-4 Antigen/*genetics , Graves Disease/*genetics , HLA-DRB1 Chains/*genetics , Hashimoto Disease/*genetics, Adult ; Age of Onset ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; India ; Male ; Middle Aged ; Young Adult
مستخلص: Autoimmune Thyroid Diseases (AITDs), including Hashimoto's thyroiditis (HT) and Graves' disease (GD), arise by the complex interaction of genes and environmental factors. The aim of present study was to study the susceptible associations of HLA-DRB1* alleles and CTLA4 +49 AG polymorphism in AITD in south India. AITD patients (n=235; HT=180; GD=55) and age/sex matched healthy controls (n, 235) were enrolled to type HLA-DRB1* alleles and 'CTLA4 +49 AG' by PCR-SSP and PCR-RFLP methods respectively. Analysis revealed CTLA4 +49 'GG' genotype was increased significantly in patients (PL: p=8.7×10 -8 ; HT: p=9.3×10 -6 ; GD: p=0.006). Decreased frequencies of 'AA' genotype was observed in patients (PL: p=9.4×10 -6 ; HT: p=0.008; GD: p=9.0×10 -6 ). Increased frequencies were observed for HLA alleles DRB1*12 (PL: p=1.42×10 -10 ; HT: p=5.75×10 -8 ; GD: p=0.002) and DRB1*11 (PL: p=0.0025; HT: p=0.013) in patients. Decreased frequencies for alleles DRB1*10 (PL: p=0.00002; HT: p=0.018; GD: p=1.63×10 -5 ) and DRB1*03 (PL: p=0.003; HT: p=0.003) were observed, suggesting a protective association. Combinatorial/Synergistic analysis have revealed an increased frequencies for 'DRB1*11+AG' (PL: p=0.022), 'DRB1*12+AG' (PL: p=6.1×10 -5 ; HT: p=0.0001), 'DRB1*04+GG' (PL: p=0.003; HT: p=0.008), 'DRB1*07+GG' (PL: p=0.009; HT: p=0.014) and 'DRB1*12+GG' (PL: p=0.005; HT: p=0.005) in patients. However, the combinations such as 'DRB1*10+AA' (PL: p=1.8×10 -6 ; HT: p=0.003) and 'DRB1*15+AA' (PL: p=0.006; GD: p=0.011) were decreased in patients showing a protective association. The 'GG/G' of CTLA4 +49AG SNP, HLA-DRB1*11/-DRB1*12 (DR5) alleles and the combinations of DRB1*11/DRB1*12 alleles with AG/GG genotype and DRB1*04/07/12 alleles with GG genotype may act as synergistic manner to confer the strong susceptibility to AITD in south India.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Autoimmune Thyroid Disease; CTLA4; DRB1*; Graves' disease; Hashimoto's thyroiditis; Human leukocyte antigen
المشرفين على المادة: 0 (CTLA-4 Antigen)
0 (CTLA4 protein, human)
0 (HLA-DRB1 Chains)
تواريخ الأحداث: Date Created: 20171128 Date Completed: 20171226 Latest Revision: 20180202
رمز التحديث: 20240628
DOI: 10.1016/j.gene.2017.11.057
PMID: 29174716
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0038
DOI:10.1016/j.gene.2017.11.057