دورية أكاديمية
Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation.
العنوان: | Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation. |
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المؤلفون: | Taban IM; School of Pharmacy & Pharmaceutical Sciences, Cardiff University , King Edward VII Avenue, Cardiff CF10 3NB, U.K., Elshihawy HEAE; Department of Organic Chemistry, Faculty of Pharmacy, Suez Canal University , Ismalia, Egypt., Torun B; School of Pharmacy & Pharmaceutical Sciences, Cardiff University , King Edward VII Avenue, Cardiff CF10 3NB, U.K.; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University , 06100 Tandogan, Ankara, Turkey., Zucchini B; School of Pharmacy & Pharmaceutical Sciences, Cardiff University , King Edward VII Avenue, Cardiff CF10 3NB, U.K.; Department of Pharmaceutical Sciences, University of Perugia , Via del Liceo, 1-06123 Perugia, Italy., Williamson CJ; School of Pharmacy & Pharmaceutical Sciences, Cardiff University , King Edward VII Avenue, Cardiff CF10 3NB, U.K., Altuwairigi D; School of Pharmacy & Pharmaceutical Sciences, Cardiff University , King Edward VII Avenue, Cardiff CF10 3NB, U.K., Ngu AST; School of Pharmacy & Pharmaceutical Sciences, Cardiff University , King Edward VII Avenue, Cardiff CF10 3NB, U.K., McLean KJ; Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester , 131 Princess Street, Manchester M1 7DN, U.K., Levy CW; Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester , 131 Princess Street, Manchester M1 7DN, U.K., Sood S; Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute , 1 Midland Road, London NW1 1AT, U.K., Marino LB; Faculty of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista , Araraquara, São Paulo14801-902, Brazil., Munro AW; Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester , 131 Princess Street, Manchester M1 7DN, U.K., de Carvalho LPS; Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute , 1 Midland Road, London NW1 1AT, U.K., Simons C; School of Pharmacy & Pharmaceutical Sciences, Cardiff University , King Edward VII Avenue, Cardiff CF10 3NB, U.K. |
المصدر: | Journal of medicinal chemistry [J Med Chem] 2017 Dec 28; Vol. 60 (24), pp. 10257-10267. Date of Electronic Publication: 2017 Dec 07. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: [Easton, Pa.] : American Chemical Society, [c1963- |
مواضيع طبية MeSH: | Cytochrome P-450 Enzyme Inhibitors/*chemistry , Cytochrome P-450 Enzyme Inhibitors/*pharmacology , Cytochrome P-450 Enzyme System/*chemistry , Mycobacterium tuberculosis/*drug effects , Small Molecule Libraries/*chemistry, Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Binding Sites ; Crystallography, X-Ray ; Cytochrome P-450 Enzyme Inhibitors/chemical synthesis ; Cytochrome P-450 Enzyme System/metabolism ; Drug Evaluation, Preclinical/methods ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Pyrazoles/chemistry ; Small Molecule Libraries/pharmacology ; Spectrophotometry, Ultraviolet |
مستخلص: | Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole and imidazole/triazole group. The imidazole and triazole series with the short -CH |
References: | Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501. (PMID: 20383002) Antimicrob Agents Chemother. 2002 Aug;46(8):2720-2. (PMID: 12121966) Nat Rev Drug Discov. 2013 May;12(5):388-404. (PMID: 23629506) Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21. (PMID: 20057044) J Chem Inf Comput Sci. 1987 Feb;27(1):21-35. (PMID: 3558506) Microbiology. 2002 Oct;148(Pt 10):2937-49. (PMID: 12368427) Proc Natl Acad Sci U S A. 2009 May 5;106(18):7426-31. (PMID: 19416919) Respir Med. 2006 Nov;100(11):1862-70. (PMID: 16949809) J Biol Chem. 2008 Nov 28;283(48):33406-16. (PMID: 18818197) Bioorg Med Chem Lett. 2012 Apr 15;22(8):2708-11. (PMID: 22437116) Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21. (PMID: 20124702) Arch Biochem Biophys. 2007 Aug 15;464(2):228-40. (PMID: 17482138) Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9311-6. (PMID: 22890978) IUCrJ. 2014 May 30;1(Pt 4):213-20. (PMID: 25075342) Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32. (PMID: 20124692) BMJ. 2015 Feb 26;350:h882. (PMID: 25721508) |
معلومات مُعتمدة: | FC001060 United Kingdom CRUK_ Cancer Research UK; BB/I020160/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; United Kingdom Wellcome Trust; FC001060 United Kingdom MRC_ Medical Research Council; FC001060 United Kingdom Wellcome Trust; BB/I019227/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council |
المشرفين على المادة: | 0 (Antitubercular Agents) 0 (Bacterial Proteins) 0 (Cytochrome P-450 Enzyme Inhibitors) 0 (Pyrazoles) 0 (Small Molecule Libraries) 0 (cytochrome P-450 CYP12A1 (house fly)) 9035-51-2 (Cytochrome P-450 Enzyme System) |
تواريخ الأحداث: | Date Created: 20171130 Date Completed: 20190401 Latest Revision: 20220129 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5748275 |
DOI: | 10.1021/acs.jmedchem.7b01562 |
PMID: | 29185746 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-4804 |
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DOI: | 10.1021/acs.jmedchem.7b01562 |