دورية أكاديمية
Iron, zinc, vitamin A and selenium status in a cohort of Indonesian infants after adjusting for inflammation using several different approaches.
| العنوان: | Iron, zinc, vitamin A and selenium status in a cohort of Indonesian infants after adjusting for inflammation using several different approaches. |
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| المؤلفون: | Diana A; 1Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia., Haszard JJ; 2Department of Human Nutrition,University of Otago,PO Box 56, Dunedin 9054,New Zealand., Purnamasari DM; 3Graduate School of Biomedical Sciences Master Program, Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia., Nurulazmi I; 1Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia., Luftimas DE; 1Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia., Rahmania S; 3Graduate School of Biomedical Sciences Master Program, Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia., Nugraha GI; 1Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia., Erhardt J; 4VitMin Lab,Kastanienweg 5, 77731 Willstaett,Germany., Gibson RS; 2Department of Human Nutrition,University of Otago,PO Box 56, Dunedin 9054,New Zealand., Houghton L; 2Department of Human Nutrition,University of Otago,PO Box 56, Dunedin 9054,New Zealand. |
| المصدر: | The British journal of nutrition [Br J Nutr] 2017 Nov; Vol. 118 (10), pp. 830-839. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing Original Publication: [Cambridge, New York] Cambridge University Press. |
| مواضيع طبية MeSH: | Nutritional Status*, Deficiency Diseases/*blood , Inflammation/*blood , Iron/*blood , Selenium/*blood , Vitamin A/*blood , Zinc/*blood, Anemia, Iron-Deficiency/blood ; Anemia, Iron-Deficiency/epidemiology ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Cohort Studies ; Cross-Sectional Studies ; Deficiency Diseases/epidemiology ; Female ; Ferritins/blood ; Humans ; Indonesia/epidemiology ; Infant ; Inflammation/complications ; Inflammation/epidemiology ; Iron Deficiencies ; Male ; Micronutrients/blood ; Orosomucoid/metabolism ; Prevalence ; Retinol-Binding Proteins/metabolism ; Selenium/deficiency ; Vitamin A Deficiency/blood ; Vitamin A Deficiency/epidemiology ; Zinc/deficiency |
| مستخلص: | Inflammation confounds the interpretation of several micronutrient biomarkers resulting in estimates that may not reflect the true burden of deficiency. We aimed to assess and compare the micronutrient status of a cohort of Indonesian infants (n 230) at aged 6, 9 and 12 months by ignoring inflammation (unadjusted) and adjusting four micronutrient biomarkers for inflammation with C-reactive protein (CRP) and α-1-glycoprotein (AGP) using the following methods: (1) arithmetic correction factors with the use of a four-stage inflammation model; and (2) regression modelling. Prevalence of infants with any inflammation (CRP>5 mg/l and/or AGP>1 g/l) was about 25% at each age. Compared with unadjusted values, regression adjustment at 6, 9 and 12 months generated the lowest (P50 % across all ages. In conclusion, without inflammation adjustment, Fe deficiency was grossly under-estimated and vitamin A and Zn deficiency over-estimated, highlighting the importance of correcting for the influence of such, before implementing programmes to alleviate micronutrient malnutrition. However, further work is needed to validate the proposed approaches with a particular focus on assessing the influence of varying degrees of inflammation (i.e. recurrent acute infections and low-grade chronic inflammation) on each affected nutrient biomarker. |
| التعليقات: | Comment in: Br J Nutr. 2017 Nov;118(10):761-762. (PMID: 29189195) |
| فهرسة مساهمة: | Keywords: AGP α-1-glycoprotein; APP acute phase proteins; BRINDA Biomarkers Reflecting Inflammation and Nutritional Determinants Anemia; CRP C-reactive protein; GM geometric mean; RBP retinol-binding protein; sTfR soluble transferrin receptor; Biomarkers; Indonesia; Inflammations; Iron; Selenium; Vitamin A; Zinc |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Micronutrients) 0 (Orosomucoid) 0 (Retinol-Binding Proteins) 11103-57-4 (Vitamin A) 9007-41-4 (C-Reactive Protein) 9007-73-2 (Ferritins) E1UOL152H7 (Iron) H6241UJ22B (Selenium) J41CSQ7QDS (Zinc) |
| تواريخ الأحداث: | Date Created: 20171201 Date Completed: 20171213 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1017/S0007114517002860 |
| PMID: | 29189196 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1475-2662 |
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| DOI: | 10.1017/S0007114517002860 |