دورية أكاديمية
أعرض في EDS

The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research.

التفاصيل البيبلوغرافية
العنوان: The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research.
المؤلفون: Fox AS; Department of Psychology and University of California, Davis, CA 95616, United States; California National Primate Research Center, University of California, Davis, CA 95616, United States. Electronic address: dfox@ucdavis.edu., Shackman AJ; Department of Psychology, University of Maryland, College Park, MD 20742, United States; Neuroscience and Cognitive Science Program, University of Maryland, College Park, MD 20742, United States; Maryland Neuroimaging Center, University of Maryland,College Park, MD 20742, United States. Electronic address: shackman@umd.edu.
المصدر: Neuroscience letters [Neurosci Lett] 2019 Feb 06; Vol. 693, pp. 58-67. Date of Electronic Publication: 2017 Nov 30.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett
أسماء مطبوعة: Publication: Limerick : Elsevier Scientific Publishers Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
مواضيع طبية MeSH: Anxiety/*diagnostic imaging , Anxiety/*physiopathology , Central Amygdaloid Nucleus/*diagnostic imaging , Central Amygdaloid Nucleus/*physiology , Fear/*physiology, Animals ; Brain Mapping ; Central Amygdaloid Nucleus/anatomy & histology ; Humans ; Models, Animal ; Models, Neurological ; Neural Pathways/physiology ; Neuroimaging/methods ; Prefrontal Cortex/physiopathology ; Primates ; Septal Nuclei/diagnostic imaging ; Septal Nuclei/physiology
مستخلص: Anxiety disorders impose a staggering burden on public health, underscoring the need to develop a deeper understanding of the distributed neural circuits underlying extreme fear and anxiety. Recent work highlights the importance of the central extended amygdala, including the central nucleus of the amygdala (Ce) and neighboring bed nucleus of the stria terminalis (BST). Anatomical data indicate that the Ce and BST form a tightly interconnected unit, where different kinds of threat-relevant information can be integrated to assemble states of fear and anxiety. Neuroimaging studies show that the Ce and BST are engaged by a broad spectrum of potentially threat-relevant cues. Mechanistic work demonstrates that the Ce and BST are critically involved in organizing defensive responses to a wide range of threats. Studies in rodents have begun to reveal the specific molecules, cells, and microcircuits within the central extended amygdala that underlie signs of fear and anxiety, but the relevance of these tantalizing discoveries to human experience and disease remains unclear. Using a combination of focal perturbations and whole-brain imaging, a new generation of nonhuman primate studies is beginning to close this gap. This work opens the door to discovering the mechanisms underlying neuroimaging measures linked to pathological fear and anxiety, to understanding how the Ce and BST interact with one another and with distal brain regions to govern defensive responses to threat, and to developing improved intervention strategies.
(Copyright © 2017. Published by Elsevier B.V.)
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معلومات مُعتمدة: P51 OD011107 United States OD NIH HHS; R01 MH107444 United States MH NIMH NIH HHS; R21 DA040717 United States DA NIDA NIH HHS; T32 MH018931 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: Affective neuroscience; Anxiety disorders; BST/BNST; Emotion; Individual differences; Neuroimaging; Nonhuman primate
تواريخ الأحداث: Date Created: 20171203 Date Completed: 20190723 Latest Revision: 20231112
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5976525
DOI: 10.1016/j.neulet.2017.11.056
PMID: 29195911
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7972
DOI:10.1016/j.neulet.2017.11.056