دورية أكاديمية
Bacteriology and Antibiogram of Urinary Tract Infection Among Female Patients in a Tertiary Health Facility in South Eastern Nigeria.
| العنوان: | Bacteriology and Antibiogram of Urinary Tract Infection Among Female Patients in a Tertiary Health Facility in South Eastern Nigeria. |
|---|---|
| المؤلفون: | Oli AN; Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical sciences Agulu, Nnamdi Azikiwe University, Awka, Nigeria., Akabueze VB; Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical sciences Agulu, Nnamdi Azikiwe University, Awka, Nigeria., Ezeudu CE; Department of Peadiatrics, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra state, Nigeria., Eleje GU; Department of Obstetrics and Gynaecology, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra state, Nigeria., Ejiofor OS; Department of Peadiatrics, Chukwuemeka Odumegwu Ojukwu University, Awka Campus, Anambra state, Nigeria., Ezebialu IU; Department of Obstetrics and Gynaecology, Chukwuemeka Odumegwu Ojukwu University Awka Campus, Anambra state, Nigeria., Oguejiofor CB; Department of Obstetrics and Gynaecology, Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra state, Nigeria., Ekejindu IM; Department of Medical Laboratory Science, Faculty of Health Science and Technology, College of Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra state, Nigeria., Emechebe GO; Department of Peadiatrics, Chukwuemeka Odumegwu Ojukwu University, Awka Campus, Anambra state, Nigeria., Okeke KN; Department of Peadiatrics, Chukwuemeka Odumegwu Ojukwu University, Awka Campus, Anambra state, Nigeria. |
| المصدر: | The open microbiology journal [Open Microbiol J] 2017 Oct 31; Vol. 11, pp. 292-300. Date of Electronic Publication: 2017 Oct 31 (Print Publication: 2017). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Open Country of Publication: United Arab Emirates NLM ID: 101480482 Publication Model: eCollection Cited Medium: Print ISSN: 1874-2858 (Print) Linking ISSN: 18742858 NLM ISO Abbreviation: Open Microbiol J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2009- : [Sharjah, U.A.E] : Bentham Open Original Publication: [Hilversum : Bentham Science Publishers, 2007-2008] |
| مستخلص: | Background: Urinary Tract Infection (UTI) is a common contagion among men and women with the incidence relatively higher among women due to their differing anatomy. An understanding of the kind of pathogens implicated in urinary tract infections as well as antibiotic susceptibility profiling may help the clinician make rationally correct empirical choice in their treatment. Objective: This study is aimed at determining the type and antibiotic susceptibility pattern of bacterial uropathogens isolated from female patients attending Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH), Awka, Nigeria. Method: Two hundred and forty patients with clinically diagnosed UTI and who were on at least 5 days' antibiotic holiday were recruited into the study. Their demographic characteristics were captured using pre-tested questionnaire. Their clean catch mid-stream urine samples were collected using sterile universal container and sent to the Microbiology Department for processing. Within 30 minutes of samples collection, the specimens were cultured and the isolates were identified, after 24 h of incubation, using standard microbiological techniques. Antibiotic susceptibility tests were done with standard antibiotic discs using the Kirby-bauer disc diffusion method. Results: Out of the 240 urine samples, 89.17% yielded significant bacteriuria. The pathogens implicated were Escherichia coli (28.5%), Staphylococcus aureus (28.0%), Salmonella spp (22.8%) and Pseudomonas aeruginosa (20.5%). HIV status, patients age, pregnancy status and marital status all significantly affected bacteriuria rate (p value < 0.05), while patients' location (sub-urban/rural dwelling), and level of education did not (p value > 0.05). The pattern of microbial resistance to antibiotics suggests that ceftazidime, fosfomycin and cefoxitin may not be used as first-line agents in the empirical treatment of UTIs rather; levofloxacin, meropenem or aztreonam should be considered. Levofloxacin was significantly effective against all the isolates and may be administered empirically while waiting for the culture result (Mean % susceptibility was 79.85). Conclusion: E. coli and S. aureus were the predominant pathogens in the study and many were resistant to the commonly prescribed antibiotics and so leave the clinicians with only few alternative drugs for UTIs treatment. Routine surveillance and monitoring studies need to be constantly conducted to update clinicians on the prevalent pathogens and the rational and empirical treatment of UTIs. Aggressive and consistent health education using every possible media is also recommended to combat the menace of drug resistance occasioned by inappropriate antibiotic use. |
| References: | Am J Med. 2002 Jul 8;113 Suppl 1A:5S-13S. (PMID: 12113866) Cad Saude Publica. 2007 Dec;23(12):2820-34. (PMID: 18157324) Indian J Urol. 2008 Oct;24(4):498-503. (PMID: 19468505) BMC Infect Dis. 2010 Mar 30;10:81. (PMID: 20353563) Int J Gen Med. 2009 Dec 29;2:171-5. (PMID: 20360901) Nat Rev Urol. 2010 Dec;7(12):653-60. (PMID: 21139641) Niger J Clin Pract. 2010 Dec;13(4):409-12. (PMID: 21220855) N Am J Med Sci. 2011 Dec;3(12):565-9. (PMID: 22363080) Ethiop J Health Sci. 2012 Jul;22(2):121-8. (PMID: 22876076) Curr Infect Dis Rep. 2013 Apr;15(2):109-15. (PMID: 23378123) Sultan Qaboos Univ Med J. 2013 Aug;13(3):359-67. (PMID: 23984019) Aging health. 2013 Oct;9(5):null. (PMID: 24391677) Int J Microbiol. 2014;2014:968716. (PMID: 24829582) Nat Rev Microbiol. 2015 May;13(5):269-84. (PMID: 25853778) Clin Microbiol Infect. 2015 Oct;21(10):899-905. (PMID: 26027916) Antibiotics (Basel). 2013 Apr 16;2(2):217-36. (PMID: 27029300) J Clin Diagn Res. 2016 Mar;10(3):DC10-3. (PMID: 27134871) Pan Afr Med J. 2017 May 30;27:66. (PMID: 29187917) |
| فهرسة مساهمة: | Keywords: Antibiogram; Bacteriology; Bacteriuria; Urinary tract infection; Uropathogens |
| تواريخ الأحداث: | Date Created: 20171206 Latest Revision: 20220311 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5688387 |
| DOI: | 10.2174/1874285801711010292 |
| PMID: | 29204224 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1874-2858 |
|---|---|
| DOI: | 10.2174/1874285801711010292 |