دورية أكاديمية

Assessment of diabetic polyneuropathy in Zanzibar: Comparison between traditional methods and an automated point-of-care nerve conduction device.

التفاصيل البيبلوغرافية
العنوان: Assessment of diabetic polyneuropathy in Zanzibar: Comparison between traditional methods and an automated point-of-care nerve conduction device.
المؤلفون: Vogt EC; Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway., Øksnes M; Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.; Department of Clinical Science, University of Bergen, Norway.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Suleiman F; Medical Department, Mnazi Mmoja Hospital, Stone Town, Zanzibar, Tanzania., Juma BA; Medical Department, Mnazi Mmoja Hospital, Stone Town, Zanzibar, Tanzania., Thordarson HB; Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway., Ommedal O; Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway., Søfteland E; Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.; Hormone Laboratory, Haukeland University Hospital, 5021 Bergen, Norway.
المصدر: Journal of clinical & translational endocrinology [J Clin Transl Endocrinol] 2017 Sep 20; Vol. 10, pp. 9-14. Date of Electronic Publication: 2017 Sep 20 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: Netherlands NLM ID: 101629335 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-6237 (Electronic) Linking ISSN: 22146237 NLM ISO Abbreviation: J Clin Transl Endocrinol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier Inc.
مستخلص: Aim: Scant information is available about the prevalence of diabetic polyneuropathy, as well as the applicability of screening tools in sub-Saharan Africa. We aimed to investigate these issues in Zanzibar (Tanzania).
Methods: One hundred consecutive diabetes patients were included from the diabetes clinic at Mnazi Mmoja Hospital. Clinical characteristics were recorded. Further, we investigated: a) self-reported numbness of the lower limbs, b) ten-point monofilament test, c) the Sibbald 60-s Tool and d) nerve conduction studies (NCS, using an automated handheld point-of-care device, the NC-stat DPNCheck).
Results: Mean age was 54 years, 90% had type 2 diabetes, and with 9 year average disease duration. Mean HbA1c was 8.5% (69 mmol/mol), blood pressure 155/88 mmHg. Sixty-two% reported numbness, 61% had positive monofilament and 79% positive Sibbald tool. NCS defined neuropathy in 45% of the patients. Only the monofilament showed appreciable concordance with the NCS, Cohen's κ 0.43.
Conclusions: The patient population was characterised by poor glycaemic control and hypertension. In line with this, neuropathy was rampant. The monofilament test tended to define more cases of probable neuropathy than the NCS, however specificity was rather low. Plantar skin thickening may have led to false positives in this population. Overall concordance was, however, appreciable, and could support continued use of monofilament as a neuropathy screening tool. The NC-stat DPNCheck could be useful in cases of diagnostic uncertainty or for research purposes in a low resource setting.
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فهرسة مساهمة: Keywords: Diabetes mellitus; Diabetic polyneuropathy (DPN); NC-stat DPNCheck; Nerve conduction studies; Sub-Saharan Africa
تواريخ الأحداث: Date Created: 20171206 Latest Revision: 20220410
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5691212
DOI: 10.1016/j.jcte.2017.09.001
PMID: 29204366
قاعدة البيانات: MEDLINE
الوصف
تدمد:2214-6237
DOI:10.1016/j.jcte.2017.09.001