دورية أكاديمية
CD34 + selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation.
| العنوان: | CD34 + selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation. |
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| المؤلفون: | Mainardi C; Department of Paediatric Oncology, Children's University Hospital, University of Padova, Padova, Italy.; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Ebinger M; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Enkel S; Transfusion Medicine Department, Tübingen University Hospital, University of Tübingen, Tübingen, Germany., Feuchtinger T; Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Teltschik HM; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Eyrich M; Department of Paediatric Oncology, University Children's Hospital, University of Würzburg, Würzburg, Germany., Schumm M; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Rabsteyn A; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Schlegel P; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Seitz C; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Schwarze CP; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Müller I; Department of Paediatric Haematology and Oncology, University Hospital Eppendorf, Hamburg, Germany., Greil J; Department of Paediatric Oncology, Haematology and Immunology, University of Heidelberg, Heidelberg, Germany., Bader P; Clinic for Paediatric and Adolescent Medicine, University Hospital Frankfurt, Frankfurt/Main, Germany., Schlegel PG; Department of Paediatric Oncology, University Children's Hospital, University of Würzburg, Würzburg, Germany., Martin D; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany.; Filderklinik, Filderstadt-Bonlanden, Germany., Holzer U; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Döring M; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Handgretinger R; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany., Lang P; Department of Paediatric Haematology/Oncology, Children's University Hospital, Tübingen, Germany. |
| المصدر: | British journal of haematology [Br J Haematol] 2018 Jan; Vol. 180 (1), pp. 90-99. Date of Electronic Publication: 2017 Dec 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Graft Survival* , Hematopoietic Stem Cell Transplantation*/adverse effects , Hematopoietic Stem Cell Transplantation*/methods , Hematopoietic Stem Cells*/metabolism, Adolescent ; Adult ; Antigens, CD34/metabolism ; Cell Lineage ; Child ; Child, Preschool ; Cohort Studies ; Female ; Graft vs Host Disease/etiology ; Hematopoiesis ; Humans ; Infant ; Male ; Prognosis ; Retreatment ; Retrospective Studies ; Transplantation Chimera ; Transplantation Conditioning ; Transplantation, Homologous ; Treatment Outcome ; Young Adult |
| مستخلص: | Poor graft function (PGF) is a severe complication of haematopoietic stem cell transplantation (HSCT) and administration of donor stem cell boosts (SCBs) represents a therapeutic option. We report 50 paediatric patients with PGF who received 61 boosts with CD34 + selected peripheral blood stem cells (PBSC) after transplantation from matched unrelated (n = 25) or mismatched related (n = 25) donors. Within 8 weeks, a significant increase in median neutrophil counts (0·6 vs. 1·516 × 10 9 /l, P < 0·05) and a decrease in red blood cell and platelet transfusion requirement (median frequencies 1 and 7 vs. 0, P < 0·0001 and <0·001), were observed, and 78·8% of patients resolved one or two of their cytopenias. 36·5% had a complete haematological response. Median lymphocyte counts for CD3 + , CD3 + CD4 + , CD19 + and CD56 + increased 8·3-, 14·2-, 22.- and 1·6-fold. The rate of de novo acute graft-versus-host disease (GvHD) grade I-III was only 6% and resolved completely. No GvHD grade IV or chronic GvHD occurred. Patients who responded to SCB displayed a trend toward better overall survival (OS) (P = 0·07). Thus, administration of CD34 + selected SCBs from alternative donors is safe and effective. Further studies are warranted to clarify the impact on immune reconstitution and survival. (© 2017 John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: haematopoietic recovery; haematopoietic stem cell transplantation; poor graft function; stem cell boost |
| المشرفين على المادة: | 0 (Antigens, CD34) |
| تواريخ الأحداث: | Date Created: 20171206 Date Completed: 20180222 Latest Revision: 20180222 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/bjh.15012 |
| PMID: | 29205259 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2141 |
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| DOI: | 10.1111/bjh.15012 |