دورية أكاديمية
أعرض في EDS

Gastroprotective activity of the methanol extract from peels of Plinia edulis (Vell.) Sobral fruits and its isolated triterpenes: maslinic and ursolic acids.

التفاصيل البيبلوغرافية
العنوان: Gastroprotective activity of the methanol extract from peels of Plinia edulis (Vell.) Sobral fruits and its isolated triterpenes: maslinic and ursolic acids.
المؤلفون: da Rosa RL; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Nesello LÂN; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Mariano LNB; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Somensi LB; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Campos A; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Pinheiro AM; Curso de Nutrição, UNIVALI, Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Costa S; Curso de Nutrição, UNIVALI, Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Rial M; Curso de Biomedicina, UNIVALI, Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Tozzo M; Curso de Biomedicina, UNIVALI, Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Cechinel-Filho V; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., de Andrade SF; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Da Silva LM; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil. lu.isamota@hotmail.com.
المصدر: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2018 Jan; Vol. 391 (1), pp. 95-101. Date of Electronic Publication: 2017 Dec 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer Verlag.
مواضيع طبية MeSH: Fruit* , Myrtaceae*, Stomach Ulcer/*prevention & control , Triterpenes/*therapeutic use, Animals ; Anti-Ulcer Agents/isolation & purification ; Anti-Ulcer Agents/therapeutic use ; Dose-Response Relationship, Drug ; Female ; Methanol/therapeutic use ; Mice ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology ; Triterpenes/isolation & purification ; Ursolic Acid
مستخلص: According to the Brazilian folk medicine, the leaves of Plinia edulis (Vell.) Sobral (Myrtaceae), known as cambuca, are indicated in the treatment of gastric disorders. Infusions of P. edulis leaves were previously demonstrated to contain both maslinic (MA) and ursolic acids (UA). Both triterpenes have also been identified in the methanolic extract of peels from P. edulis fruit (MEPPE); however, the antiulcer effects of MEPPE have not yet been studied. This study therefore evaluates the gastroprotective potential of MEPPE, MA, and UA using ethanol/HCl- and indomethacin-induced gastric ulcers in mice. In addition, the in vitro effects of these compounds on the H + , K + -ATPase activity and on the free radical DPPH were measured. When used at concentration of 100 μg/mL, both MEPPE and UA were found to reduce the DPPH radical levels by 78.66 and 60.14%, respectively. However, MA did not reduce DPPH radical levels. Our results illustrated the antiulcer effects of MEPPE, MA, and UA against experimental ulcer models when administered by either the oral or the intraperitoneal routes. In addition, MEPPE reduced the size of ethanol/HCl-induced ulcers in a dose-dependent manner (log half-maximal effective oral dose, LogED 50  = 1.09). Interestingly, UA promoted gastroprotection at lower doses than MA by increasing the production of mucin levels at 692%; however, it does not alter the activity of H + , K + -ATPase. In contrast, both MEPPE and MA, when incubated at concentrations of 10 and 100 μg/mL, inhibited H + , K + -ATPase activity in 61.81, 68.37, 54.04, and 70.45%, respectively. These results confirm that MEPPE, MA, and UA display gastroprotective activity through different modes of action; MA inhibits H + , K + -ATPase activity, whereas UA favour the mucus barrier.
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فهرسة مساهمة: Keywords: Antiulcer; Fruits; Gastric ulcer; H+, K+-ATPase; Triterpene
المشرفين على المادة: 0 (Anti-Ulcer Agents)
0 (Plant Extracts)
0 (Triterpenes)
E233J88OHQ (maslinic acid)
Y4S76JWI15 (Methanol)
تواريخ الأحداث: Date Created: 20171207 Date Completed: 20180813 Latest Revision: 20231213
رمز التحديث: 20231215
DOI: 10.1007/s00210-017-1442-8
PMID: 29209743
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1912
DOI:10.1007/s00210-017-1442-8