دورية أكاديمية
Gastroprotective activity of the methanol extract from peels of Plinia edulis (Vell.) Sobral fruits and its isolated triterpenes: maslinic and ursolic acids.
العنوان: | Gastroprotective activity of the methanol extract from peels of Plinia edulis (Vell.) Sobral fruits and its isolated triterpenes: maslinic and ursolic acids. |
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المؤلفون: | da Rosa RL; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Nesello LÂN; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Mariano LNB; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Somensi LB; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Campos A; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Pinheiro AM; Curso de Nutrição, UNIVALI, Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Costa S; Curso de Nutrição, UNIVALI, Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Rial M; Curso de Biomedicina, UNIVALI, Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Tozzo M; Curso de Biomedicina, UNIVALI, Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Cechinel-Filho V; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., de Andrade SF; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil., Da Silva LM; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajai (UNIVALI), Campus Itajai, Rua Uruguai, 458, Centro, Santa Catarina, 88302-901, Brazil. lu.isamota@hotmail.com. |
المصدر: | Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2018 Jan; Vol. 391 (1), pp. 95-101. Date of Electronic Publication: 2017 Dec 05. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin, New York, Springer Verlag. |
مواضيع طبية MeSH: | Fruit* , Myrtaceae*, Stomach Ulcer/*prevention & control , Triterpenes/*therapeutic use, Animals ; Anti-Ulcer Agents/isolation & purification ; Anti-Ulcer Agents/therapeutic use ; Dose-Response Relationship, Drug ; Female ; Methanol/therapeutic use ; Mice ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology ; Triterpenes/isolation & purification ; Ursolic Acid |
مستخلص: | According to the Brazilian folk medicine, the leaves of Plinia edulis (Vell.) Sobral (Myrtaceae), known as cambuca, are indicated in the treatment of gastric disorders. Infusions of P. edulis leaves were previously demonstrated to contain both maslinic (MA) and ursolic acids (UA). Both triterpenes have also been identified in the methanolic extract of peels from P. edulis fruit (MEPPE); however, the antiulcer effects of MEPPE have not yet been studied. This study therefore evaluates the gastroprotective potential of MEPPE, MA, and UA using ethanol/HCl- and indomethacin-induced gastric ulcers in mice. In addition, the in vitro effects of these compounds on the H + , K + -ATPase activity and on the free radical DPPH were measured. When used at concentration of 100 μg/mL, both MEPPE and UA were found to reduce the DPPH radical levels by 78.66 and 60.14%, respectively. However, MA did not reduce DPPH radical levels. Our results illustrated the antiulcer effects of MEPPE, MA, and UA against experimental ulcer models when administered by either the oral or the intraperitoneal routes. In addition, MEPPE reduced the size of ethanol/HCl-induced ulcers in a dose-dependent manner (log half-maximal effective oral dose, LogED |
References: | Curr Opin Pharmacol. 2014 Dec;19:17-23. (PMID: 24956584) Bioorg Med Chem Lett. 2012 Apr 1;22(7):2488-93. (PMID: 22370266) J Physiol Pharmacol. 2006 Sep;57 Suppl 3:67-79. (PMID: 17033106) Arq Gastroenterol. 2017 Apr-Jun;54(2):135-138. (PMID: 28327824) Evid Based Complement Alternat Med. 2015;2015:439506. (PMID: 25954316) Inflammopharmacology. 2010 Oct;18(5):209-21. (PMID: 20596896) Biol Pharm Bull. 2007 Nov;30(11):2075-8. (PMID: 17978478) Evid Based Complement Alternat Med. 2016;2016:4758734. (PMID: 26904143) Food Chem. 2016 Feb 15;193:187-95. (PMID: 26433307) J Ethnopharmacol. 2015 Dec 4;175:75-85. (PMID: 26364940) Cancer Lett. 2009 Jan 8;273(1):44-54. (PMID: 18790561) Nat Prod Res. 2013 Mar;27(4-5):438-47. (PMID: 23126495) Gastroenterology. 2008 Jul;135(1):41-60. (PMID: 18549814) Ren Fail. 2014 Apr;36(3):419-31. (PMID: 24344651) Gastroenterol Rep (Oxf). 2015 Aug;3(3):201-8. (PMID: 25698559) Naunyn Schmiedebergs Arch Pharmacol. 2016 Apr;389(4):403-17. (PMID: 26758066) J Ethnopharmacol. 2008 Aug 13;118(3):527-9. (PMID: 18583075) Naunyn Schmiedebergs Arch Pharmacol. 2017 Jun;390(6):661-666. (PMID: 28365824) J Agric Food Chem. 2012 Oct 17;60(41):10220-5. (PMID: 23003682) Pharmacogn Rev. 2010 Jul;4(8):118-26. (PMID: 22228951) Arq Neuropsiquiatr. 2016 Jun;74(6):482-8. (PMID: 27332074) J Physiol Pharmacol. 2013 Apr;64(2):157-65. (PMID: 23756390) Chem Biol Interact. 2016 Oct 25;258:30-9. (PMID: 27545833) Pharmacol Biochem Behav. 2013 Sep;110:255-64. (PMID: 23932918) J Ethnopharmacol. 2012 Jan 31;139(2):519-26. (PMID: 22154965) Arq Bras Cir Dig. 2012 Apr-Jun;25(2):96-100. (PMID: 23381751) Curr Opin Gastroenterol. 1999 Nov;15(6):463-72. (PMID: 17023992) Inflammopharmacology. 2017 Feb 7;:null. (PMID: 28176198) Int J Mycobacteriol. 2016 Dec;5(4):417-425. (PMID: 27931683) J Ethnopharmacol. 2005 Aug 22;100(1-2):92-4. (PMID: 15994040) |
فهرسة مساهمة: | Keywords: Antiulcer; Fruits; Gastric ulcer; H+, K+-ATPase; Triterpene |
المشرفين على المادة: | 0 (Anti-Ulcer Agents) 0 (Plant Extracts) 0 (Triterpenes) E233J88OHQ (maslinic acid) Y4S76JWI15 (Methanol) |
تواريخ الأحداث: | Date Created: 20171207 Date Completed: 20180813 Latest Revision: 20231213 |
رمز التحديث: | 20231215 |
DOI: | 10.1007/s00210-017-1442-8 |
PMID: | 29209743 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-1912 |
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DOI: | 10.1007/s00210-017-1442-8 |