التفاصيل البيبلوغرافية
| العنوان: |
Animal models of preeclampsia: translational failings and why. |
| المؤلفون: |
Marshall SA; School of BioSciences, The University of Melbourne , Parkville, Victoria , Australia., Hannan NJ; The Translational Obstetrics Group, Mercy Hospital for Women, Department of Obstetrics and Gynaecology, The University of Melbourne , Victoria , Australia., Jelinic M; School of BioSciences, The University of Melbourne , Parkville, Victoria , Australia., Nguyen TPH; School of BioSciences, The University of Melbourne , Parkville, Victoria , Australia., Girling JE; Gynaecology Research Centre, Department of Obstetrics and Gynaecology, The University of Melbourne and Royal Women's Hospital , Parkville, Victoria , Australia.; Department of Anatomy, University of Otago , Dunedin , New Zealand., Parry LJ; School of BioSciences, The University of Melbourne , Parkville, Victoria , Australia. |
| المصدر: |
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2018 Apr 01; Vol. 314 (4), pp. R499-R508. Date of Electronic Publication: 2017 Dec 06. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Bethesda, Md. : American Physiological Society |
| مواضيع طبية MeSH: |
Blood Pressure*, Pre-Eclampsia/*physiopathology , Translational Research, Biomedical/*methods, Animals ; Biomarkers/blood ; Disease Models, Animal ; Female ; Humans ; Placental Circulation ; Pre-Eclampsia/blood ; Pre-Eclampsia/etiology ; Pregnancy ; Risk Factors ; Signal Transduction ; Species Specificity |
| مستخلص: |
Preeclampsia affects up to 8% of pregnancies worldwide and is a leading cause of both maternal and fetal morbidity and mortality. Our current understanding of the cause(s) of preeclampsia is far from complete, and the lack of a single reliable animal model that recapitulates all aspects of the disease further confounds our understanding. This is partially due to the heterogeneous nature of the disease, coupled with our evolving understanding of its etiology. Nevertheless, animal models are still highly relevant and useful tools that help us better understand the pathophysiology of specific aspects of preeclampsia. This review summarizes the various types and characteristics of animal models used to study preeclampsia, highlighting particular features of these models relevant to clinical translation. This review points out the strengths and limitations of these models to illustrate the importance of using the appropriate model depending on the research question. |
| فهرسة مساهمة: |
Keywords: animal models; preeclampsia; translational failings |
| المشرفين على المادة: |
0 (Biomarkers) |
| تواريخ الأحداث: |
Date Created: 20171208 Date Completed: 20190114 Latest Revision: 20211204 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1152/ajpregu.00355.2017 |
| PMID: |
29212809 |
| قاعدة البيانات: |
MEDLINE |
