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Autoimmune limbic encephalitis: A manifestation of systemic lupus erythematosus in the central nervous system.

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العنوان: Autoimmune limbic encephalitis: A manifestation of systemic lupus erythematosus in the central nervous system.
المؤلفون: Angst DBM; Department of Neurology, Hospital Santa Marcelina, São Paulo SP, Brazil., de Figueiredo NSV; Department of Neurology, Hospital Santa Marcelina, São Paulo SP, Brazil., Passarelli V; Department of Neurology, Hospital Santa Marcelina, São Paulo SP, Brazil., Baldocchi MA; Department of Neurology, Hospital Santa Marcelina, São Paulo SP, Brazil., Rocha MSG; Department of Neurology, Hospital Santa Marcelina, São Paulo SP, Brazil., Brucki SMD; Department of Neurology, Hospital Santa Marcelina, São Paulo SP, Brazil.
المصدر: Dementia & neuropsychologia [Dement Neuropsychol] 2015 Apr-Jun; Vol. 9 (2), pp. 189-195.
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento Country of Publication: Brazil NLM ID: 101506587 Publication Model: Print Cited Medium: Print ISSN: 1980-5764 (Print) Linking ISSN: 19805764 NLM ISO Abbreviation: Dement Neuropsychol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: São Paulo, SP, Brazil : Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
Original Publication: São Paulo : Associação Neurologia Cognitiva e do Comportamento
مستخلص: Autoimmune limbic encephalitis (ALE) associated with systemic lupus erythematosus (SLE) is a rare entity with few reports in the literature to date. In general, ALE associated with SLE has a satisfactory response to immunosuppressive treatment (RIT), but the pathogenesis of this association is poorly understood and may include an autoimmunity component. We report a case study describing the diagnosis and management of limbic encephalitis in a patient with active Systemic Lupus Erythematosus disease (SLE) and past medical history of cancer (endometrial adenocarcinoma in 2004 and papillary urothelial carcinoma in 2011 with curative treatment), followed over a one-year period. We discuss the possible association between limbic encephalitis and all past neoplastic and immune-mediated conditions of this patient. In this particularly case, autoimmunity was the most relevant factor associated with limbic encephalitis given negative neoplastic screening. Moreover, a good response was observed to immunotherapy, not seen with paraneoplastic limbic encephalitis, which is associated with poor response. In this case, the association of ALE with SLE is possible, since laboratory testing disclosed lupic activity and the patient had involvement of other systems (such as hematologic) during the period. However, the presence of other surface membrane antibodies are possible in the search for alternative etiologies.
Competing Interests: Disclosure: The authors report no conflicts of interest.
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فهرسة مساهمة: Keywords: limbic encephalitis; lupus erythematosus systemic; neoplasms
Local Abstract: [Publisher, Portuguese] Encefalite Límbica Autoimune (EL) associada a lúpus eritematoso sistêmico (LES) é uma entidade rara, com poucos relatos na literatura até o momento. Em geral, EL associada com LES tem uma resposta satisfatória ao tratamento imunossupressor, mas a patogênese desta associação é pouco compreendida e pode incluir um componente de autoimunidade. Descrevemos em um estudo de caso o diagnóstico e o tratamento empregado na encefalite límbica ocorrida no contexto de uma paciente com LES ativo e história pregressa de doenças neoplásicas (adenocarcinoma endometrial em 2004 e carcinoma papilar urotelial em 2011 ambos com o tratamento curativo), a qual foi seguida durante um ano. Discutimos uma possível associação de encefalite límbica e todos os antecedentes neoplásicos e imunomediados desta paciente. Neste caso em particular, a autoimunidade é o fator mais relevante relacionado com a encefalite límbica devido a uma triagem neoplásica negativa. Além disso, houve uma grande resposta com a imunossupressão, o que não é visto na encefalite límbica paraneoplásica, mais relacionada com uma má resposta. Neste caso, a associação de EL com LES é possível, uma vez que testes laboratoriais confirmaram a atividade lúpica, bem como a paciente apresentava envolvimento de outros sistemas (como hematológico) neste interim. No entanto, a presença de outros anticorpos de superfície da membrana é possível em busca de diferentes etiologias.
تواريخ الأحداث: Date Created: 20171208 Latest Revision: 20201001
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5619358
DOI: 10.1590/1980-57642015DN92000014
PMID: 29213961
قاعدة البيانات: MEDLINE
الوصف
تدمد:1980-5764
DOI:10.1590/1980-57642015DN92000014