دورية أكاديمية
أعرض في EDS

Association between memory impairment and brain metabolite concentrations in North Korean refugees with posttraumatic stress disorder.

التفاصيل البيبلوغرافية
العنوان: Association between memory impairment and brain metabolite concentrations in North Korean refugees with posttraumatic stress disorder.
المؤلفون: Shin JE; Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea., Choi CH; Department of Radiology, Chungbuk National University Hospital, Cheongju, Republic of Korea., Lee JM; Computational NeuroImage Analysis Laboratory, Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea., Kwon JS; Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Psychiatry and Institute of Human Behavioral Medicine in SNU-MRC, Seoul National University College of Medicine, Seoul, Republic of Korea., Lee SH; Department of Psychiatry, National Medical Center, Seoul, Republic of Korea., Kim HC; Department of Psychiatry, National Medical Center, Seoul, Republic of Korea., Han NY; Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea., Choi SH; Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Psychiatry and Institute of Human Behavioral Medicine in SNU-MRC, Seoul National University College of Medicine, Seoul, Republic of Korea., Yoo SY; Department of Psychiatry, National Medical Center, Seoul, Republic of Korea.
المصدر: PloS one [PLoS One] 2017 Dec 07; Vol. 12 (12), pp. e0188953. Date of Electronic Publication: 2017 Dec 07 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Refugees*, Brain/*metabolism , Memory Disorders/*etiology , Stress Disorders, Post-Traumatic/*metabolism, Adult ; Brain/diagnostic imaging ; Democratic People's Republic of Korea ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Memory Disorders/diagnostic imaging ; Middle Aged ; Neuropsychological Tests ; Stress Disorders, Post-Traumatic/complications ; Stress Disorders, Post-Traumatic/diagnostic imaging
مستخلص: Individuals with posttraumatic stress disorder (PTSD) had experiences of enormous psychological stress that can result in neurocognitive and neurochemical changes. To date, the causal relationship between them remains unclear. The present study is to investigate the association between neurocognitive characteristics and neural metabolite concentrations in North Korean refugees with PTSD. A total of 53 North Korean refugees with or without PTSD underwent neurocognitive function tests. For neural metabolite scanning, magnetic resonance spectroscopy of the hippocampus and anterior cingulate cortex (ACC) has been conducted. We assessed between-group differences in neurocognitive test scores and metabolite levels. Additionally, a multiple regression analysis was carried out to evaluate the association between neurocognitive function and metabolite levels in patients with PTSD. Memory function, but not other neurocognitive functions, was significantly lower in the PTSD group compared with the non-PTSD group. Hippocampal N-acetylaspartate (NAA) levels were not different between groups; however, NAA levels were significantly lower in the ACC of the PTSD group than the non-PTSD group (t = 2.424, p = 0.019). The multiple regression analysis showed a negative association between hippocampal NAA levels and delayed recall score on the auditory verbal learning test (β = -1.744, p = 0.011) in the non-PTSD group, but not in the PTSD group. We identified specific memory impairment and the role of NAA levels in PTSD. Our findings suggest that hippocampal NAA has a protective role in memory impairment and development of PTSD after exposure to traumatic events.
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تواريخ الأحداث: Date Created: 20171208 Date Completed: 20171226 Latest Revision: 20181113
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC5720673
DOI: 10.1371/journal.pone.0188953
PMID: 29216235
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0188953