دورية أكاديمية
أعرض في EDS

Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice.

التفاصيل البيبلوغرافية
العنوان: Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice.
المؤلفون: Ferreira FBD; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., Dos Santos C; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., Bruxel MA; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., Nunes EA; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., Spiller F; Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil., Rafacho A; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
المصدر: International journal of experimental pathology [Int J Exp Pathol] 2017 Dec; Vol. 98 (6), pp. 329-340. Date of Electronic Publication: 2017 Dec 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 9014042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2613 (Electronic) Linking ISSN: 09599673 NLM ISO Abbreviation: Int J Exp Pathol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, OX : Wiley, c1990-
مواضيع طبية MeSH: Blood Glucose/*biosynthesis , Cecum/*metabolism , Homeostasis/*physiology , Sepsis/*mortality, Animals ; Cecum/surgery ; Disease Models, Animal ; Hypoglycemic Agents ; Insulin Resistance ; Ligation/methods ; Liver/metabolism ; Male ; Mice ; Punctures/methods
مستخلص: Sepsis is associated with high mortality. Both critically ill humans and animal models of sepsis exhibit changes in their glucose homeostasis, that is, hypoglycaemia, with the progression of infection. However, the relationship between basal glycaemia, glucose tolerance and insulin sensitivity is not well understood. Thus, we aimed to evaluate this glucose homeostasis triad at the late stage of sepsis (24 h after surgery) in male Swiss mice subjected to lethal and sublethal sepsis by the caecal ligation and puncture (CLP) model. The percentage of survival 24 h after CLP procedure in the Lethal and Sublethal groups was around 66% and 100% respectively. Both Lethal and Sublethal groups became hypoglycaemic in fasting and fed states 24 h after surgery. The pronounced fed hypoglycaemia in the Lethal group was not due to worsening anorexic behaviour or hepatic inability to deliver glucose in relation to the Sublethal group. Reduction in insulin sensitivity in CLP mice occurred in a lethality-dependent manner and was not associated with glucose intolerance. Analysis of oral and intraperitoneal glucose tolerance tests, as well as the gastrointestinal motility data, indicated that CLP mice had reduced intestinal glucose absorption. Altogether, we suggest cessation of appetite and intestinal glucose malabsorption are key contributors to the hypoglycaemic state observed during experimental severe sepsis.
(© 2017 The Authors. International Journal of Experimental Pathology © 2017 International Journal of Experimental Pathology.)
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فهرسة مساهمة: Keywords: appetite; caecal ligation and puncture; glucose tolerance; insulin sensitivity; metabolism; sepsis
المشرفين على المادة: 0 (Blood Glucose)
0 (Hypoglycemic Agents)
تواريخ الأحداث: Date Created: 20171212 Date Completed: 20180912 Latest Revision: 20181201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5826970
DOI: 10.1111/iep.12255
PMID: 29226508
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2613
DOI:10.1111/iep.12255