دورية أكاديمية
Antibiotic Resistance and the Risk of Recurrent Bacteremia.
| العنوان: | Antibiotic Resistance and the Risk of Recurrent Bacteremia. |
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| المؤلفون: | Woudt SHS; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven., de Greeff SC; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven., Schoffelen AF; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven., Vlek ALM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.; Department of Medical Microbiology and Immunology, Diakonessenhuis, Utrecht., Bonten MJM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven.; Department of Medical Microbiology, University Medical Center Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands. |
| مؤلفون مشاركون: | Infectious Diseases Surveillance Information System–Antimicrobial Resistance (ISIS-AR) Study Group |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2018 May 17; Vol. 66 (11), pp. 1651-1657. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Bacteria/*drug effects , Bacterial Infections/*microbiology, Bacterial Infections/drug therapy ; Bacterial Infections/epidemiology ; Drug Resistance, Bacterial ; Humans ; Netherlands/epidemiology ; Recurrence ; Risk Factors |
| مستخلص: | Background: Direct health effects of antibiotic resistance are difficult to assess. We quantified the risk of recurrent bacteremia associated with resistance. Methods: We extracted antimicrobial susceptibility testing data on blood isolates from the Dutch surveillance system for antimicrobial resistance between 2008 and 2017. First and first recurrent (4-30 days) bacteremia episodes were categorized as susceptible, single nonsusceptible, or co-nonsusceptible to third-generation cephalosporins without or with carbapenems (Enterobacteriaceae), ceftazidime without or with carbapenems (Pseudomonas species), aminopenicillins without or with vancomycin (Enterococcus species), or as methicillin-sensitive/-resistant S. aureus (MSSA/MRSA). We calculated risks of recurrent bacteremia after nonsusceptible vs susceptible first bacteremia, estimated the crude population attributable effect of resistance for the Netherlands, and calculated risks of nonsusceptible recurrent bacteremia after a susceptible first episode. Results: Risk ratios for recurrent bacteremia after a single- and co-nonsusceptible first episode, respectively, vs susceptible first episode, were 1.7 (95% confidence interval [CI], 1.5-2.0) and 5.2 (95% CI, 2.1-12.4) for Enterobacteriaceae, 1.3 (95% CI, 0.5-3.1) and 5.0 (95% CI, 2.9-8.5) for Pseudomonas species, 1.4 (95% CI, 1.2-1.7) and 1.6 (95% CI, 0.6-4.2) for Enterococcus species, and 1.6 (95% CI, 1.1-2.4) for MRSA vs MSSA. The estimated population annual number of recurrent bacteremias associated with nonsusceptibility was 40. The risk of nonsusceptible recurrent bacteremia after a susceptible first episode was at most 0.4% (Pseudomonas species). Conclusions: Although antibiotic nonsusceptibility was consistently associated with higher risks of recurrent bacteremia, the estimated annual number of additional recurrent episodes in the Netherlands (40) was rather limited. |
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| فهرسة مساهمة: | Investigator: JWT Cohen Stuart; AJL Weersink; CMJE Vandenbroucke-Grauls; CE Visser; ML van Ogtrop; DJ Kaersenhout; M Scholing; BC van Hees; PHJ van Keulen; JAJW Kluytmans; EM Kraan; EE Mattsson; FW Sebens; E de Jong; HME Frénay; B Maraha; AJ van Griethuysen; W Silvis; A Demeulemeester; BB Wintermans; M van Trijp; A Ott; JP Arends; GA Kampinga; D Veenendaal; C Hol; EIGB de Brauwer; FS Stals; LJ Bakker; JW Dorigo-Zetsma; B Ridwan; JH van Zeijl; AT Bernards; S Erkens-Hulshof; BM de Jongh; BJM Vlaminckx; MH Nabuurs-Franssen; S Kuipers; BMW Diederen; DC Melles; M van Rijn; S Dinant; O Pontesilli; P de Man; N Vaessen; MA Leversteijn-van Hall; EPM van Elzakker; AE Muller; NH Renders; DW van Dam; AGM Buiting; ALM Vlek; MPD Deege; FNJ Frakking; ITMA Overdevest; RW Bosboom; T Trienekens; GP Voorn; GJHM Ruijs; MJHM Wolfhagen; J Alblas; W Altorf-van der Kuil; L Blijboom; S Groenendijk; J van Heereveld; R Hertroys; JC Monen; DW Notermans; EA Reuland; MI van Triest; CCH Wielders |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20171212 Date Completed: 20191016 Latest Revision: 20191016 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5960995 |
| DOI: | 10.1093/cid/cix1076 |
| PMID: | 29228127 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/cix1076 |