دورية أكاديمية
أعرض في EDS

Mother-to-newborn transmission of mycobacterial L-forms and Vδ2 T-cell response in placentobiome of BCG-vaccinated pregnant women.

التفاصيل البيبلوغرافية
العنوان: Mother-to-newborn transmission of mycobacterial L-forms and Vδ2 T-cell response in placentobiome of BCG-vaccinated pregnant women.
المؤلفون: Dimova T; Institute of Biology and Immunology of Reproduction 'Acad. K.Bratanov', Bulgarian Academy of Sciences, Department of Immunobiology of reproduction, Sofia, 1113, Bulgaria. tanyadimova@yahoo.com., Terzieva A; Institute of Biology and Immunology of Reproduction 'Acad. K.Bratanov', Bulgarian Academy of Sciences, Department of Immunobiology of reproduction, Sofia, 1113, Bulgaria., Djerov L; University Obstetrics and Gynecology Hospital 'Maichin Dom', Medical University, Department of Obstetrics and Gynecology, Sofia, 1431, Bulgaria., Dimitrova V; University Obstetrics and Gynecology Hospital 'Maichin Dom', Medical University, Department of Obstetrics and Gynecology, Sofia, 1431, Bulgaria., Nikolov A; University Obstetrics and Gynecology Hospital 'Maichin Dom', Medical University, Department of Obstetrics and Gynecology, Sofia, 1431, Bulgaria., Grozdanov P; Institute of Microbiology 'Acad. St. Angelov', Bulgarian Academy of Sciences, Department of infectious microbiology, Sofia, 1113, Bulgaria., Markova N; Institute of Microbiology 'Acad. St. Angelov', Bulgarian Academy of Sciences, Department of infectious microbiology, Sofia, 1113, Bulgaria.
المصدر: Scientific reports [Sci Rep] 2017 Dec 12; Vol. 7 (1), pp. 17366. Date of Electronic Publication: 2017 Dec 12.
نوع المنشور: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Infectious Disease Transmission, Vertical*, BCG Vaccine/*immunology , Intraepithelial Lymphocytes/*immunology , L Forms/*isolation & purification , Microbiota/*immunology , Mycobacterium bovis/*isolation & purification , Placenta/*microbiology, BCG Vaccine/administration & dosage ; Female ; Humans ; Infant, Newborn ; L Forms/immunology ; Mothers ; Mycobacterium bovis/immunology ; Placenta/cytology ; Pregnancy ; Symbiosis/immunology ; T-Lymphocytes ; Tuberculosis/prevention & control ; Vaccination/adverse effects
مستخلص: The ability of bacteria to exist as a population of self-replicating forms with defective or entirely missing cell wall (L-forms) is an adaptive mechanism for their survival and reproduction under unfavorable conditions. Bacterial mother-to-fetus transfer is a universal phenomenon in the animal kingdom. However, data about vertical transfer of L bacterial forms are extremely scarce. Bacille Calmette-Guérin is an attenuated strain of M. bovis and the only licensed vaccine used for tuberculosis prevention. We already have shown that filterable L-forms of BCG exist freely in the vaccine and are able to reproduce and to form colonies. The present study was focused on the placental microbiome in the context of mother's BCG vaccination. Here we report an isolation of filterable mycobacterial L-form cultures from gestational tissues and blood of healthy newborns delivered by healthy BCG-vaccinated mothers after normal pregnancy. Of note, vertically transmitted mycobacterial L-forms as a part of placentobiome of the pregnant women didn't influence the number of resident pathogen-reactive Vδ2 cells. Placenta colonization with mycobacterial L-forms occurs by maternal blood-to-decidua transfer very early in gestation. Together, these data showed that BCG L-forms have the capacity to pass trans-placental barrier and that maternal BCG vaccination affects the placentobiome.
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المشرفين على المادة: 0 (BCG Vaccine)
تواريخ الأحداث: Date Created: 20171214 Date Completed: 20190718 Latest Revision: 20190718
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5727158
DOI: 10.1038/s41598-017-17644-z
PMID: 29234108
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-017-17644-z