دورية أكاديمية
Narrowing the spectrum: the new frontier of precision antimicrobials.
العنوان: | Narrowing the spectrum: the new frontier of precision antimicrobials. |
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المؤلفون: | Paharik AE; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Schreiber HL 4th; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Spaulding CN; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Dodson KW; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Hultgren SJ; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. hultgren@wustl.edu.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA. hultgren@wustl.edu. |
المصدر: | Genome medicine [Genome Med] 2017 Dec 14; Vol. 9 (1), pp. 110. Date of Electronic Publication: 2017 Dec 14. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BioMed Central |
مواضيع طبية MeSH: | Anti-Infective Agents/*therapeutic use , Gastrointestinal Microbiome/*drug effects , Precision Medicine/*methods, Animals ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/adverse effects ; Bacterial Infections/drug therapy ; Humans |
مستخلص: | Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens. |
References: | J Intensive Care Med. 2014 Jul-Aug;29(4):190-9. (PMID: 23753229) Lancet Infect Dis. 2013 Dec;13(12):1057-98. (PMID: 24252483) Genome Med. 2016 Apr 13;8(1):39. (PMID: 27074706) Infect Immun. 2015 Feb;83(2):456-69. (PMID: 25404026) Nature. 2017 Jun 22;546(7659):528-532. (PMID: 28614296) Sci Transl Med. 2011 Nov 16;3(109):109ra115. (PMID: 22089451) Nature. 2012 Sep 13;489(7415):220-30. (PMID: 22972295) Sci Transl Med. 2017 Sep 6;9(406):. (PMID: 28878013) Nat Rev Drug Discov. 2017 Jul;16(7):457-471. (PMID: 28337021) |
معلومات مُعتمدة: | R37 AI048689 United States AI NIAID NIH HHS; P50DK064540 United States NH NIH HHS; R01 AI048689 United States AI NIAID NIH HHS; R01 DK051406 United States DK NIDDK NIH HHS; R01AI048689 United States NH NIH HHS; F31 DK107057 United States DK NIDDK NIH HHS; RO1DK051406 United States NH NIH HHS; 1F31DK107057 United States NH NIH HHS; P50 DK064540 United States DK NIDDK NIH HHS |
المشرفين على المادة: | 0 (Anti-Infective Agents) |
تواريخ الأحداث: | Date Created: 20171216 Date Completed: 20180723 Latest Revision: 20220408 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5729598 |
DOI: | 10.1186/s13073-017-0504-3 |
PMID: | 29241446 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1756-994X |
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DOI: | 10.1186/s13073-017-0504-3 |