دورية أكاديمية
أعرض في EDS

Narrowing the spectrum: the new frontier of precision antimicrobials.

التفاصيل البيبلوغرافية
العنوان: Narrowing the spectrum: the new frontier of precision antimicrobials.
المؤلفون: Paharik AE; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Schreiber HL 4th; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Spaulding CN; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Dodson KW; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA., Hultgren SJ; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. hultgren@wustl.edu.; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, 63110, USA. hultgren@wustl.edu.
المصدر: Genome medicine [Genome Med] 2017 Dec 14; Vol. 9 (1), pp. 110. Date of Electronic Publication: 2017 Dec 14.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central
مواضيع طبية MeSH: Anti-Infective Agents/*therapeutic use , Gastrointestinal Microbiome/*drug effects , Precision Medicine/*methods, Animals ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/adverse effects ; Bacterial Infections/drug therapy ; Humans
مستخلص: Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens.
References: J Intensive Care Med. 2014 Jul-Aug;29(4):190-9. (PMID: 23753229)
Lancet Infect Dis. 2013 Dec;13(12):1057-98. (PMID: 24252483)
Genome Med. 2016 Apr 13;8(1):39. (PMID: 27074706)
Infect Immun. 2015 Feb;83(2):456-69. (PMID: 25404026)
Nature. 2017 Jun 22;546(7659):528-532. (PMID: 28614296)
Sci Transl Med. 2011 Nov 16;3(109):109ra115. (PMID: 22089451)
Nature. 2012 Sep 13;489(7415):220-30. (PMID: 22972295)
Sci Transl Med. 2017 Sep 6;9(406):. (PMID: 28878013)
Nat Rev Drug Discov. 2017 Jul;16(7):457-471. (PMID: 28337021)
معلومات مُعتمدة: R37 AI048689 United States AI NIAID NIH HHS; P50DK064540 United States NH NIH HHS; R01 AI048689 United States AI NIAID NIH HHS; R01 DK051406 United States DK NIDDK NIH HHS; R01AI048689 United States NH NIH HHS; F31 DK107057 United States DK NIDDK NIH HHS; RO1DK051406 United States NH NIH HHS; 1F31DK107057 United States NH NIH HHS; P50 DK064540 United States DK NIDDK NIH HHS
المشرفين على المادة: 0 (Anti-Infective Agents)
تواريخ الأحداث: Date Created: 20171216 Date Completed: 20180723 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5729598
DOI: 10.1186/s13073-017-0504-3
PMID: 29241446
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-994X
DOI:10.1186/s13073-017-0504-3