دورية أكاديمية
The impact of adipogenic diet on rats' tissue trace elements content.
| العنوان: | The impact of adipogenic diet on rats' tissue trace elements content. |
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| المؤلفون: | Tinkov AA, Gatiatulina ER, Popova EV, Polyakova VS, Skalvaya AA, Agletdinov EF, Nikonorov AA, Radysh IV, Kkarganov MY, Skalny AV |
| المصدر: | Patologicheskaia fiziologiia i eksperimental'naia terapiia [Patol Fiziol Eksp Ter] 2016 Oct-Dec; Vol. 60 (4), pp. 79-85. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Izdatelstvo Meditsina Country of Publication: Russia (Federation) NLM ID: 0376421 Publication Model: Print Cited Medium: Print ISSN: 0031-2991 (Print) Linking ISSN: 00312991 NLM ISO Abbreviation: Patol Fiziol Eksp Ter Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Meditsina |
| مواضيع طبية MeSH: | Dietary Fats/*pharmacology , Lipids/*blood , Lipoproteins/*blood , Trace Elements/*blood, Animals ; Male ; Rats ; Rats, Wistar |
| مستخلص: | The Purpose: The influence of high-fat diet (HFD) on trace elements status, adipokine level, and markers of carbohydrate and lipid metabolism in weanling Wistar rats was investigated. Methods: A total of 20 male 1-months-old Wistar rats divided into two equal groups were used in the present study. The first group of animals obtained a standard diet (STD), whereas animals from the second group (NAFLD) were maintained on high-fat diet containing 10 and 31.6% of total calories from fat, respectively, during 1 month. Fat diet (HFD). Trace element status (using inductively coupled plasma mass spectrometry), serum levels of insulin, adiponectin, and leptin (using enzyme-linked immunosorbent assay), total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glucose (spectrophotometrically), apolipoprotein A1 (ApoA1) and B (ApoB) (using immunoturbidimetric method) were assessed. Results: It was shown that 1-month HFD feeding resulted in significant increase of EDAT, RPAT, total adipose tissue mass, and adipocyte area. HFD-fed animals were also characterized by a significant increase in circulating leptin levels and leptin-to-adiponectin ratio as compared to the control ones. No significant HFD-related difference in serum lipid spectrum, adiponectin, apolipoproteins, glucose, insulin, and HOMA-IR were revealed. Liver Cu, I, Mn, Se, Zn; EDAT Cr, V, Co, Cu, Fe,I, and RPAT Co, Cu, I, Cr, V, Fe, and Zn were significantly decreased in HFD-fed rats in comparison with the control group levels. Hair Co, Mn, Si, and V levels significantly exceeded the respective control values, whereas Se and I content were decreased in studied animals. At the same time, only serum Cu was significantly decreased in HFD-fed rats. Conclusion: The interplay between the impaired trace elements metabolism of HFD-fed weanling Wistar rats and disorder of adipokine balance was demonstrated. It is supposed that the altered trace elements status is primary and precedes other metabolic obesity-related disturbances. |
| المشرفين على المادة: | 0 (Dietary Fats) 0 (Lipids) 0 (Lipoproteins) 0 (Trace Elements) |
| تواريخ الأحداث: | Date Created: 20171216 Date Completed: 20180118 Latest Revision: 20180118 |
| رمز التحديث: | 20240628 |
| PMID: | 29244927 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0031-2991 |
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