دورية أكاديمية
أعرض في EDS

Joint diseases: from connexins to gap junctions.

التفاصيل البيبلوغرافية
العنوان: Joint diseases: from connexins to gap junctions.
المؤلفون: Donahue HJ; Department of Biomedical Engineering, Virginia Commonwealth University, 601 West Main Street, Richmond, Virginia 23284, USA., Qu RW; Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616, USA., Genetos DC; Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616, USA.
المصدر: Nature reviews. Rheumatology [Nat Rev Rheumatol] 2017 Dec 19; Vol. 14 (1), pp. 42-51.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101500080 Publication Model: Print Cited Medium: Internet ISSN: 1759-4804 (Electronic) Linking ISSN: 17594790 NLM ISO Abbreviation: Nat Rev Rheumatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group
مواضيع طبية MeSH: Connexin 43/*metabolism , Connexins/*metabolism , Gap Junctions/*metabolism , Joint Diseases/*metabolism, Animals ; Arthritis, Rheumatoid/metabolism ; Bone and Bones/metabolism ; Cartilage/metabolism ; Cell Communication/physiology ; Cell Differentiation/physiology ; Connexins/physiology ; Connexins/therapeutic use ; Gap Junctions/physiology ; Humans ; Ion Channel Gating/physiology ; Ion Channels/physiology ; Mice ; Mice, Knockout ; Musculoskeletal System/metabolism ; Musculoskeletal System/pathology ; Osteoarthritis/metabolism ; Osteoporosis/metabolism ; Synovial Membrane/metabolism
مستخلص: Connexons form the basis of hemichannels and gap junctions. They are composed of six tetraspan proteins called connexins. Connexons can function as individual hemichannels, releasing cytosolic factors (such as ATP) into the pericellular environment. Alternatively, two hemichannel connexons from neighbouring cells can come together to form gap junctions, membrane-spanning channels that facilitate cell-cell communication by enabling signalling molecules of approximately 1 kDa to pass from one cell to an adjacent cell. Connexins are expressed in joint tissues including bone, cartilage, skeletal muscle and the synovium. Indicative of their importance as gap junction components, connexins are also known as gap junction proteins, but individual connexin proteins are gaining recognition for their channel-independent roles, which include scaffolding and signalling functions. Considerable evidence indicates that connexons contribute to the function of bone and muscle, but less is known about the function of connexons in other joint tissues. However, the implication that connexins and gap junctional channels might be involved in joint disease, including age-related bone loss, osteoarthritis and rheumatoid arthritis, emphasizes the need for further research into these areas and highlights the therapeutic potential of connexins.
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معلومات مُعتمدة: R01 AG013087 United States AG NIA NIH HHS
المشرفين على المادة: 0 (Connexin 43)
0 (Connexins)
0 (Ion Channels)
تواريخ الأحداث: Date Created: 20171220 Date Completed: 20171227 Latest Revision: 20210814
رمز التحديث: 20240628
DOI: 10.1038/nrrheum.2017.204
PMID: 29255213
قاعدة البيانات: MEDLINE
الوصف
تدمد:1759-4804
DOI:10.1038/nrrheum.2017.204