دورية أكاديمية
أعرض في EDS

T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.

التفاصيل البيبلوغرافية
العنوان: T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.
المؤلفون: Burrack AL; Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, United States., Martinov T; Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, United States., Fife BT; Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, United States.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2017 Dec 05; Vol. 8, pp. 343. Date of Electronic Publication: 2017 Dec 05 (Print Publication: 2017).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مستخلص: Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the immune system. Despite improvements in insulin analogs and continuous blood glucose level monitoring, there is no cure for T1D, and some individuals develop life-threatening complications. Pancreas and islet transplantation have been attractive therapeutic approaches; however, transplants containing insulin-producing cells are vulnerable to both recurrent autoimmunity and conventional allograft rejection. Current immune suppression treatments subdue the immune system, but not without complications. Ideally a successful approach would target only the destructive immune cells and leave the remaining immune system intact to fight foreign pathogens. This review discusses the autoimmune diabetes disease process, diabetic complications that warrant a transplant, and alloimmunity. First, we describe the current understanding of autoimmune destruction of beta cells including the roles of CD4 and CD8 T cells and several possibilities for antigen-specific tolerance induction. Second, we outline diabetic complications necessitating beta cell replacement. Third, we discuss transplant recognition, potential sources for beta cell replacement, and tolerance-promoting therapies under development. We hypothesize that a better understanding of autoreactive T cell targets during disease pathogenesis and alloimmunity following transplant destruction could enhance attempts to re-establish tolerance to beta cells.
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معلومات مُعتمدة: P01 AI035296 United States AI NIAID NIH HHS; R01 AI106791 United States AI NIAID NIH HHS; T32 DK007203 United States DK NIDDK NIH HHS; U24 AI118635 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: T cells; alloimmunity; autoimmune diseases; immunology; tolerance induction; transplantation immunology; type 1 diabetes
تواريخ الأحداث: Date Created: 20171221 Latest Revision: 20220408
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5723426
DOI: 10.3389/fendo.2017.00343
PMID: 29259578
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2017.00343