دورية أكاديمية
أعرض في EDS

Exploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi.

التفاصيل البيبلوغرافية
العنوان: Exploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi.
المؤلفون: Verma S; a Department of Biochemistry , University of Utah School of Medicine , Salt Lake City , Utah , USA., Shakya VPS; a Department of Biochemistry , University of Utah School of Medicine , Salt Lake City , Utah , USA., Idnurm A; b School of BioSciences , University of Melbourne , Parkville , VIC , Australia.
المصدر: Virulence [Virulence] 2018 Jan 01; Vol. 9 (1), pp. 426-446.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, Tex. : Landes Bioscience
مواضيع طبية MeSH: Energy Metabolism*, Fungi/*growth & development , Fungi/*physiology , Mitochondria/*metabolism, Antifungal Agents/isolation & purification ; Antifungal Agents/pharmacology ; Humans ; Mycoses/drug therapy ; Virulence
مستخلص: Mitochondria are best known for their role in the production of ATP; however, recent research implicates other mitochondrial functions in the virulence of human pathogenic fungi. Inhibitors of mitochondrial succinate dehydrogenase or the electron transport chain are successfully used to combat plant pathogenic fungi, but similar inhibition of mitochondrial functions has not been pursued for applications in medical mycology. Advances in understanding mitochondrial function relevant to human pathogenic fungi are in four major directions: 1) the role of mitochondrial morphology in virulence, 2) mitochondrial genetics, with a focus on mitochondrial DNA recombination and mitochondrial inheritance 3) the role of mitochondria in drug resistance, and 4) the interaction of mitochondria with other organelles. Collectively, despite the similarities in mitochondrial functions between fungi and animals, this organelle is currently an under-explored potential target to treat medical mycoses. Future research could define and then exploit those mitochondrial components best suited as drug targets.
References: PLoS Genet. 2013;9(9):e1003771. (PMID: 24039607)
Biochem Soc Trans. 2012 Apr;40(2):445-50. (PMID: 22435828)
Genetics. 2003 Apr;163(4):1315-25. (PMID: 12702677)
Eukaryot Cell. 2003 Feb;2(1):9-18. (PMID: 12582118)
J Bacteriol. 1972 May;110(2):628-32. (PMID: 4336692)
Gene. 2005 Jul 18;354:15-21. (PMID: 15896930)
Nat Commun. 2016 Oct 10;7:13021. (PMID: 27721450)
Mol Microbiol. 2012 Aug;85(3):557-73. (PMID: 22757963)
Nucleic Acids Res. 2003 Jun 15;31(12):3081-91. (PMID: 12799436)
mBio. 2016 Feb 23;7(1):e01919-15. (PMID: 26908577)
Pest Manag Sci. 2002 Jul;58(7):649-62. (PMID: 12146165)
PLoS Biol. 2008 May 6;6(5):e110. (PMID: 18462019)
J Phys Chem A. 2008 Dec 18;112(50):12911-8. (PMID: 18563875)
Antimicrob Agents Chemother. 2013 Nov;57(11):5580-99. (PMID: 23979757)
mBio. 2015 Sep 01;6(5):e00868-15. (PMID: 26330512)
Mol Microbiol. 2011 Feb;79(4):968-89. (PMID: 21299651)
Curr Opin Immunol. 2015 Oct;36:73-9. (PMID: 26210301)
Nature. 2009 Jan 22;457(7228):471-4. (PMID: 19043401)
J Bacteriol. 2001 Feb;183(3):865-72. (PMID: 11208783)
FEBS Lett. 1998 Dec 4;440(3):325-31. (PMID: 9872396)
Antimicrob Agents Chemother. 2009 Jul;53(7):3034-41. (PMID: 19380598)
Fungal Genet Biol. 2015 May;78:16-48. (PMID: 25721988)
Microb Pathog. 2007 Feb-Mar;42(2-3):88-93. (PMID: 17241762)
Antimicrob Agents Chemother. 2014 Nov;58(11):6904-12. (PMID: 25199772)
J Biol Chem. 2017 Aug 4;292(31):12754-12763. (PMID: 28615445)
Microbiol Res. 2015 Sep;178:51-8. (PMID: 26302847)
Nature. 2005 Oct 27;437(7063):1360-4. (PMID: 16222245)
Nat Cell Biol. 2007 Jan;9(1):99-105. (PMID: 17173038)
mBio. 2013 Aug 13;4(4):. (PMID: 23943761)
Proc Natl Acad Sci U S A. 1968 Mar;59(3):903-10. (PMID: 5238670)
Mol Plant Pathol. 2013 Dec;14(9):870-84. (PMID: 23782532)
mBio. 2013 Apr 23;4(2):e00112-13. (PMID: 23611907)
Ann N Y Acad Sci. 1991;640:59-64. (PMID: 1663716)
Nature. 2001 May 24;411(6836):438. (PMID: 11373666)
Eukaryot Cell. 2009 Nov;8(11):1706-20. (PMID: 19717740)
Eur J Cell Biol. 2015 Jul-Sep;94(7-9):292-308. (PMID: 26116073)
Sci Transl Med. 2012 Dec 19;4(165):165rv13. (PMID: 23253612)
Cold Spring Harb Perspect Biol. 2011 Sep 01;3(9):a004424. (PMID: 21813400)
Biochimie. 2014 May;100:3-17. (PMID: 24316280)
Genetics. 2017 Sep;207(1):327-346. (PMID: 28679543)
Ann Neurol. 1989 Dec;26(6):719-23. (PMID: 2557792)
J Biol Chem. 2001 Dec 21;276(51):47844-52. (PMID: 11602584)
Antimicrob Agents Chemother. 2015 Nov 23;60(2):873-80. (PMID: 26596944)
Biochim Biophys Acta. 2011 Jan;1814(1):29-35. (PMID: 20619366)
Science. 2012 Aug 31;337(6098):1062-5. (PMID: 22936770)
J Biol Chem. 2000 Dec 1;275(48):37347-56. (PMID: 10980204)
Cell Microbiol. 2013 Sep;15(9):1572-84. (PMID: 23490206)
Antimicrob Agents Chemother. 2013 Jan;57(1):532-42. (PMID: 23147730)
Phytopathology. 2013 Sep;103(9):880-7. (PMID: 23593940)
Cell. 2015 Jul 30;162(3):540-51. (PMID: 26232224)
Nat Commun. 2017 Jan 04;8:13932. (PMID: 28051091)
Cold Spring Harb Perspect Biol. 2013 Aug 01;5(8):a011312. (PMID: 23906713)
Fungal Genet Biol. 2015 Aug;81:150-9. (PMID: 25626172)
PLoS Pathog. 2015 Apr 24;11(4):e1004834. (PMID: 25909486)
Int J Med Microbiol. 2017 Jan;307(1):37-43. (PMID: 27939177)
FEMS Yeast Res. 2015 Jun;15(4):fov027. (PMID: 26002841)
Genet Mol Res. 2007 Oct 05;6(4):1051-63. (PMID: 18273798)
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22044-9. (PMID: 21135205)
PLoS Pathog. 2010 Nov 24;6(11):e1001209. (PMID: 21124817)
Biochim Biophys Acta. 2002 Jun 7;1576(1-2):176-82. (PMID: 12031499)
Antimicrob Agents Chemother. 2011 May;55(5):1852-60. (PMID: 21321146)
Front Cell Infect Microbiol. 2017 Jan 18;7:4. (PMID: 28149831)
Comp Funct Genomics. 2003;4(1):37-46. (PMID: 18629096)
Cell. 2009 Aug 21;138(4):628-44. (PMID: 19703392)
EMBO J. 2007 Jul 11;26(13):3157-68. (PMID: 17568774)
Mol Biol Cell. 2001 Feb;12(2):297-308. (PMID: 11179416)
FEMS Yeast Res. 2013 Jun;13(4):411-21. (PMID: 23496820)
Nat Commun. 2014 Oct 17;5:5194. (PMID: 25323068)
Nucleic Acids Res. 2017 Jan 4;45(D1):D592-D596. (PMID: 27738138)
Mol Microbiol. 2012 Dec;86(6):1345-63. (PMID: 23043393)
Mol Microbiol. 2008 Oct;70(1):27-43. (PMID: 18721228)
Infect Immun. 2013 Jul;81(7):2616-25. (PMID: 23670558)
Eukaryot Cell. 2014 Feb;13(2):186-9. (PMID: 24243797)
Trends Mol Med. 2002 Feb;8(2):76-81. (PMID: 11815273)
PLoS Pathog. 2010 Apr 22;6(4):e1000850. (PMID: 20421942)
J Clin Invest. 1962 Sep;41:1776-804. (PMID: 14467237)
Genomics. 1992 Dec;14(4):897-911. (PMID: 1478671)
PLoS Genet. 2013;9(9):e1003769. (PMID: 24039606)
Eukaryot Cell. 2011 Nov;10(11):1376-83. (PMID: 21926328)
Eukaryot Cell. 2011 Feb;10(2):187-97. (PMID: 21131438)
Eukaryot Cell. 2007 Nov;6(11):2112-21. (PMID: 17715361)
Eukaryot Cell. 2011 Feb;10(2):207-25. (PMID: 21131439)
mSphere. 2016 May 25;1(3):. (PMID: 27303738)
Virulence. 2017 Feb 17;8(2):159-168. (PMID: 27191707)
Eukaryot Cell. 2012 Apr;11(4):532-44. (PMID: 22286093)
Mol Genet Genomics. 2008 Nov;280(5):365-74. (PMID: 18797929)
J Biol Chem. 2001 Feb 9;276(6):4020-7. (PMID: 11054416)
Nature. 1988 Feb 25;331(6158):717-9. (PMID: 2830540)
Eukaryot Cell. 2012 Aug;11(8):1055-66. (PMID: 22707484)
Curr Genet. 2008 May;53(5):313-22. (PMID: 18343926)
Genes Dev. 1995 Jan 1;9(1):47-58. (PMID: 7828851)
Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12809-12814. (PMID: 27791100)
PLoS Pathog. 2010 Sep 30;6(9):e1001124. (PMID: 20941352)
PLoS One. 2016 Jul 20;11(7):e0158724. (PMID: 27438017)
Yeast. 2014 Aug;31(8):299-308. (PMID: 24898203)
Mol Cell Biol. 2005 Mar;25(5):1669-79. (PMID: 15713626)
Annu Rev Genet. 2005;39:503-36. (PMID: 16285870)
J Biol Chem. 2013 May 10;288(19):13194-203. (PMID: 23539616)
EMBO J. 2003 May 15;22(10):2505-15. (PMID: 12743044)
Cell Microbiol. 2007 Dec;9(12):2938-54. (PMID: 17645752)
Antimicrob Agents Chemother. 2004 May;48(5):1788-96. (PMID: 15105136)
Front Microbiol. 2016 May 12;7:716. (PMID: 27433157)
Science. 2009 Jul 24;325(5939):477-81. (PMID: 19556461)
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12980-5. (PMID: 19651610)
Biochim Biophys Acta. 2015 Mar;1850(3):461-75. (PMID: 24746984)
Cell Metab. 2007 Feb;5(2):143-9. (PMID: 17276356)
Science. 1987 Jan 30;235(4788):576-80. (PMID: 3027892)
mSphere. 2016 Jan 13;1(1):. (PMID: 27303693)
Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):E3358-66. (PMID: 23151513)
J Biol Chem. 2006 Mar 10;281(10):6376-84. (PMID: 16407254)
Antimicrob Agents Chemother. 2006 Apr;50(4):1384-92. (PMID: 16569856)
Nature. 2014 Dec 18;516(7531):414-7. (PMID: 25274306)
Mitochondrion. 2012 Sep;12(5):514-9. (PMID: 22824459)
PLoS Pathog. 2009 Jan;5(1):e1000268. (PMID: 19148266)
Science. 1998 Aug 28;281(5381):1309-12. (PMID: 9721092)
BMC Genomics. 2012 Dec 12;13:698. (PMID: 23234273)
Cell. 1993 Jan 15;72(1):61-71. (PMID: 8422683)
Science. 2011 Oct 21;334(6054):358-62. (PMID: 21885730)
J Cell Biol. 1981 Dec;91(3 Pt 2):227s-255s. (PMID: 7033239)
Cell Chem Biol. 2016 Aug 18;23(8):978-991. (PMID: 27524297)
Science. 1988 Dec 9;242(4884):1427-30. (PMID: 3201231)
Trends Endocrinol Metab. 2014 Oct;25(10):528-37. (PMID: 25048297)
Adv Exp Med Biol. 2009;652:69-84. (PMID: 20225020)
Plant Cell. 2012 Sep;24(9):3805-22. (PMID: 22968717)
Microbiology (Reading). 2010 Mar;156(Pt 3):929-939. (PMID: 20019084)
Fungal Genet Biol. 2015 May;78:65-75. (PMID: 25173822)
Mol Microbiol. 2015 Dec;98(5):930-45. (PMID: 26272083)
mBio. 2017 Oct 31;8(5):. (PMID: 29089435)
Nat Rev Microbiol. 2010 Oct;8(10):693-705. (PMID: 20818415)
Annu Rev Biochem. 2007;76:723-49. (PMID: 17263664)
Antioxid Redox Signal. 2010 Apr;12(4):537-77. (PMID: 19650713)
FEMS Yeast Res. 2009 May;9(3):489-503. (PMID: 19281475)
Mol Cell Biol. 2008 Oct;28(19):5851-64. (PMID: 18644857)
mBio. 2015 Mar 31;6(2):. (PMID: 25827419)
Biomed Res Int. 2015;2015:305716. (PMID: 26448933)
PLoS Genet. 2015 Oct 30;11(10):e1005626. (PMID: 26517373)
FEBS Lett. 2002 Mar 27;515(1-3):25-8. (PMID: 11943188)
FEBS Lett. 2003 Jan 16;534(1-3):39-48. (PMID: 12527359)
Chimia (Aarau). 2015 Aug 19;69(7):425-434. (PMID: 28482975)
FEMS Microbiol Lett. 2003 Apr 11;221(1):63-71. (PMID: 12694912)
PLoS Pathog. 2017 May 10;13(5):e1006355. (PMID: 28489916)
J Cell Sci. 2009 Jul 15;122(Pt 14):2402-12. (PMID: 19531588)
Virulence. 2010 May-Jun;1(3):197-201. (PMID: 21178442)
Mol Ecol. 2009 Jun;18(12):2628-42. (PMID: 19457185)
Med Mycol. 2008 Nov;46(7):647-54. (PMID: 18608923)
PLoS One. 2012;7(6):e39812. (PMID: 22761908)
Eur J Biochem. 1996 Nov 1;241(3):779-86. (PMID: 8944766)
Phytopathology. 2013 Jan;103(1):81-90. (PMID: 23228145)
PLoS One. 2014 Oct 22;9(10):e111089. (PMID: 25337713)
معلومات مُعتمدة: R21 AI094364 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Aspergillus fumigatus; Candida; Cryptococcus; azole antifungal; heme; iron; mitochondria; pathogenicity; recombination
المشرفين على المادة: 0 (Antifungal Agents)
تواريخ الأحداث: Date Created: 20171221 Date Completed: 20180917 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC5955198
DOI: 10.1080/21505594.2017.1414133
PMID: 29261004
قاعدة البيانات: MEDLINE
الوصف
تدمد:2150-5608
DOI:10.1080/21505594.2017.1414133