دورية أكاديمية
أعرض في EDS

Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice.

التفاصيل البيبلوغرافية
العنوان: Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice.
المؤلفون: Sack BK; Center for Infectious Disease Research, Seattle, WA USA., Mikolajczak SA; Center for Infectious Disease Research, Seattle, WA USA., Fishbaugher M; Center for Infectious Disease Research, Seattle, WA USA., Vaughan AM; Center for Infectious Disease Research, Seattle, WA USA., Flannery EL; Center for Infectious Disease Research, Seattle, WA USA., Nguyen T; Center for Infectious Disease Research, Seattle, WA USA., Betz W; Center for Infectious Disease Research, Seattle, WA USA., Jane Navarro M; Center for Infectious Disease Research, Seattle, WA USA., Foquet L; Center for Infectious Disease Research, Seattle, WA USA., Steel RWJ; Center for Infectious Disease Research, Seattle, WA USA., Billman ZP; Departments of Laboratory Medicine and Microbiology and the Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA USA., Murphy SC; Center for Infectious Disease Research, Seattle, WA USA.; Departments of Laboratory Medicine and Microbiology and the Center for Emerging and Re-emerging Infectious Diseases, University of Washington, Seattle, WA USA., Hoffman SL; Sanaria, Inc., Rockville, MD USA., Chakravarty S; Sanaria, Inc., Rockville, MD USA., Sim BKL; Sanaria, Inc., Rockville, MD USA., Behet M; Radboud University, Nijmegen, The Netherlands., Reuling IJ; Radboud University, Nijmegen, The Netherlands., Walk J; Radboud University, Nijmegen, The Netherlands., Scholzen A; Radboud University, Nijmegen, The Netherlands., Sauerwein RW; Radboud University, Nijmegen, The Netherlands., Ishizuka AS; National Institutes of Health, Bethesda, MD USA., Flynn B; National Institutes of Health, Bethesda, MD USA., Seder RA; National Institutes of Health, Bethesda, MD USA., Kappe SHI; Center for Infectious Disease Research, Seattle, WA USA.; Department of Global Health, University of Washington, Seattle, WA USA.
المصدر: NPJ vaccines [NPJ Vaccines] 2017 Oct 09; Vol. 2, pp. 27. Date of Electronic Publication: 2017 Oct 09 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: eCollection Cited Medium: Print ISSN: 2059-0105 (Print) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Springer Nature in partnership with the Sealy Center for Vaccine Development, [2016]-
مستخلص: A malaria vaccine that prevents infection will be an important new tool in continued efforts of malaria elimination, and such vaccines are under intense development for the major human malaria parasite Plasmodium falciparum ( Pf ). Antibodies elicited by vaccines can block the initial phases of parasite infection when sporozoites are deposited into the skin by mosquito bite and then target the liver for further development. However, there are currently no standardized in vivo preclinical models that can measure the inhibitory activity of antibody specificities against Pf sporozoite infection via mosquito bite. Here, we use human liver-chimeric mice as a challenge model to assess prevention of natural Pf sporozoite infection by antibodies. We demonstrate that these mice are consistently infected with Pf by mosquito bite and that this challenge can be combined with passive transfer of either monoclonal antibodies or polyclonal human IgG from immune serum to measure antibody-mediated blocking of parasite infection using bioluminescent imaging. This methodology is useful to down-select functional antibodies and to investigate mechanisms or immune correlates of protection in clinical trials, thereby informing rational vaccine optimization.
Competing Interests: The authors declare that they have no competing financial interests.
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معلومات مُعتمدة: F32 AI114113 United States AI NIAID NIH HHS; T32 GM007171 United States GM NIGMS NIH HHS; T32 GM145449 United States GM NIGMS NIH HHS
تواريخ الأحداث: Date Created: 20171222 Latest Revision: 20230906
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5634440
DOI: 10.1038/s41541-017-0028-2
PMID: 29263882
قاعدة البيانات: MEDLINE
الوصف
تدمد:2059-0105
DOI:10.1038/s41541-017-0028-2