دورية أكاديمية
Analysis of over 1500 triatomine vectors from across the US, predominantly Texas, for Trypanosoma cruzi infection and discrete typing units.
| العنوان: | Analysis of over 1500 triatomine vectors from across the US, predominantly Texas, for Trypanosoma cruzi infection and discrete typing units. |
|---|---|
| المؤلفون: | Curtis-Robles R; Department of Veterinary Integrative Biosciences, 4458 TAMU, Texas A&M University, College Station, TX 77843, USA. Electronic address: RCurtis@cvm.tamu.edu., Auckland LD; Department of Veterinary Integrative Biosciences, 4458 TAMU, Texas A&M University, College Station, TX 77843, USA. Electronic address: LAuckland@cvm.tamu.edu., Snowden KF; Department of Veterinary Pathobiology, 4467 TAMU, Texas A&M University, College Station, TX 77843, USA. Electronic address: KSnowden@cvm.tamu.edu., Hamer GL; Department of Entomology, 2475 TAMU, Texas A&M University, College Station, TX 77843, USA. Electronic address: GHamer@tamu.edu., Hamer SA; Department of Veterinary Integrative Biosciences, 4458 TAMU, Texas A&M University, College Station, TX 77843, USA. Electronic address: SHamer@cvm.tamu.edu. |
| المصدر: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2018 Mar; Vol. 58, pp. 171-180. Date of Electronic Publication: 2017 Dec 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Insect Vectors/*classification , Insect Vectors/*genetics , Triatoma/*classification , Triatoma/*genetics , Trypanosoma cruzi/*genetics, Animals ; Chagas Disease/parasitology ; Chagas Disease/transmission ; Female ; Genes, Insect ; Genes, Protozoan ; Geography ; Humans ; Insect Vectors/parasitology ; Male ; Odds Ratio ; Pharmacogenomic Variants ; RNA, Spliced Leader ; Triatoma/parasitology ; United States/epidemiology |
| مستخلص: | Across the Americas, triatomine insects harbor diverse strains of Trypanosoma cruzi (T. cruzi), agent of Chagas disease. Geographic patterns of vector infection and parasite strain associations, especially in vectors encountered by the public, may be useful in assessing entomological risk, but are largely unknown across the US. We collected Triatoma spp. from across the US (mainly Texas), in part using a citizen science initiative, and amplified T. cruzi DNA to determine infection prevalence and parasite discrete typing units (DTUs). We found 54.4% infection prevalence in 1510 triatomines of 6 species; prevalence in adult T. gerstaeckeri (63.3%; n=897) and T. lecticularia (66.7%; n=66) was greater than in T. sanguisuga (47.6%; n=315), T. indictiva (47.8% n=67), T. rubida (14.1%; n=64), and T. protracta (10.5%; n=19). The odds of infection in adults were 9.73 times higher than in nymphs (95% CI 4.46-25.83). PCR of the spliced leader intergenic region (SL-IR) and/or the putative lathosterol/episterol oxidase TcSC5D gene revealed exclusively T. cruzi DTUs TcI and TcIV; 5.5% of T. cruzi-positive samples were not successfully typed. T. gerstaeckeri (n=548) were more frequently infected with TcI (53.9%) than TcIV (34.4%), and 11.9% showed mixed TcI/TcIV infections. In contrast, T. sanguisuga (n=135) were more frequently infected with TcIV (79.3%) than TcI (15.6%), and 5.2% showed mixed infections. Relative abundance of parasite DTUs varied spatially, with both TcI and TcIV co-circulating in vectors in central Texas, while TcIV predominated in northern Texas. Given prior findings implicating TcI in human disease and TcI and TcIV in animal disease in the US, knowledge of spatial distribution of T. cruzi infection and DTUs in vectors is important to understanding public and veterinary health risk of T. cruzi infection. (Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Discrete typing unit; Texas; Triatomine; Trypanosoma cruzi; United States; Vector |
| المشرفين على المادة: | 0 (RNA, Spliced Leader) |
| تواريخ الأحداث: | Date Created: 20171223 Date Completed: 20190110 Latest Revision: 20190110 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.meegid.2017.12.016 |
| PMID: | 29269323 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1567-7257 |
|---|---|
| DOI: | 10.1016/j.meegid.2017.12.016 |