دورية أكاديمية
[Study on biopharmaceutics classification system for Chinese materia medica of extract of Huanglian].
| العنوان: | [Study on biopharmaceutics classification system for Chinese materia medica of extract of Huanglian]. |
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| المؤلفون: | Liu Y; Beijing University of Chinese Medicine, Beijing 100029, China., Yin XW; Beijing University of Chinese Medicine, Beijing 100029, China., Wang ZY; Beijing University of Chinese Medicine, Beijing 100029, China., Li XL; Beijing University of Chinese Medicine, Beijing 100029, China., Pan M; Beijing University of Chinese Medicine, Beijing 100029, China., Li YP; Beijing University of Chinese Medicine, Beijing 100029, China., Dong L; Beijing University of Chinese Medicine, Beijing 100029, China. |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2017 Nov; Vol. 42 (21), pp. 4127-4134. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Drugs, Chinese Herbal/*chemistry , Materia Medica/*classification , Plant Extracts/*chemistry, Animals ; Biopharmaceutics ; Drugs, Chinese Herbal/classification ; Intestinal Absorption ; Plant Extracts/classification |
| مستخلص: | One of the advantages of biopharmaceutics classification system of Chinese materia medica (CMMBCS) is expanding the classification research level from single ingredient to multi-components of Chinese herb, and from multi-components research to holistic research of the Chinese materia medica. In present paper, the alkaloids of extract of huanglian were chosen as the main research object to explore their change rules in solubility and intestinal permeability of single-component and multi-components, and to determine the biopharmaceutical classification of extract of Huanglian from holistic level. The typical shake-flask method and HPLC were used to detect the solubility of single ingredient of alkaloids from extract of huanglian. The quantitative research of alkaloids in intestinal absorption was measured in single-pass intestinal perfusion experiment while permeability coefficient of extract of huanglian was calculated by self-defined weight coefficient method. Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. (Copyright© by the Chinese Pharmaceutical Association.) |
| فهرسة مساهمة: | Keywords: alkaloids; biopharmaceutics classification system of Chinese materia medica; extract of huanglian; intestinal permeability; solubility |
| المشرفين على المادة: | 0 (Drugs, Chinese Herbal) 0 (Materia Medica) 0 (Plant Extracts) 0 (huanglian) |
| تواريخ الأحداث: | Date Created: 20171223 Date Completed: 20190506 Latest Revision: 20190506 |
| رمز التحديث: | 20231215 |
| DOI: | 10.19540/j.cnki.cjcmm.20171017.002 |
| PMID: | 29271150 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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| DOI: | 10.19540/j.cnki.cjcmm.20171017.002 |