دورية أكاديمية
GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction.
| العنوان: | GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction. |
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| المؤلفون: | Duncker PC; Holtom-Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109.; Multiple Sclerosis Center, Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109.; Graduate Program in Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109; and., Stoolman JS; Holtom-Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109.; Multiple Sclerosis Center, Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109.; Graduate Program in Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109; and., Huber AK; Holtom-Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109.; Multiple Sclerosis Center, Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109., Segal BM; Holtom-Garrett Program in Neuroimmunology, Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109; bmsegal@med.umich.edu.; Multiple Sclerosis Center, Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109.; Graduate Program in Immunology, University of Michigan School of Medicine, Ann Arbor, MI 48109; and.; Neuroscience Program, University of Michigan School of Medicine, Ann Arbor, MI 48109. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Feb 01; Vol. 200 (3), pp. 966-973. Date of Electronic Publication: 2017 Dec 29. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | CD4-Positive T-Lymphocytes/*immunology , Central Nervous System/*cytology , Central Nervous System/*pathology , Encephalomyelitis, Autoimmune, Experimental/*pathology , Granulocyte-Macrophage Colony-Stimulating Factor/*immunology , Myelin-Oligodendrocyte Glycoprotein/*immunology, Adoptive Transfer ; Animals ; B-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/transplantation ; Dendritic Cells/immunology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Lung/pathology ; Lymph Nodes/cytology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myelin-Oligodendrocyte Glycoprotein/administration & dosage ; Neutrophils/immunology ; Peptide Fragments/administration & dosage ; Peptide Fragments/immunology ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism |
| مستخلص: | GM-CSF has been portrayed as a critical cytokine in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and, ostensibly, in multiple sclerosis. C57BL/6 mice deficient in GM-CSF are resistant to EAE induced by immunization with myelin oligodendrocyte glycoprotein (MOG) (Copyright © 2018 by The American Association of Immunologists, Inc.) |
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| معلومات مُعتمدة: | R01 NS105385 United States NS NINDS NIH HHS; R21 NS103215 United States NS NINDS NIH HHS; T32 AI007413 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Csf2ra protein, mouse) 0 (Myelin-Oligodendrocyte Glycoprotein) 0 (Peptide Fragments) 0 (Receptors, Granulocyte-Macrophage Colony-Stimulating Factor) 0 (myelin oligodendrocyte glycoprotein (35-55)) 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor) |
| تواريخ الأحداث: | Date Created: 20171231 Date Completed: 20181001 Latest Revision: 20190201 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5780231 |
| DOI: | 10.4049/jimmunol.1701484 |
| PMID: | 29288202 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
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| DOI: | 10.4049/jimmunol.1701484 |