دورية أكاديمية
Elevated absolute NK cell counts in peripheral blood predict good prognosis in chronic lymphocytic leukemia.
| العنوان: | Elevated absolute NK cell counts in peripheral blood predict good prognosis in chronic lymphocytic leukemia. |
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| المؤلفون: | Wang WT; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Zhu HY; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Wu YJ; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Xia Y; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Wu JZ; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Wu W; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Liang JH; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Wang L; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Fan L; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Li JY; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China., Xu W; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China. xuwei10000@hotmail.com.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China. xuwei10000@hotmail.com.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China. xuwei10000@hotmail.com. |
| المصدر: | Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2018 Mar; Vol. 144 (3), pp. 449-457. Date of Electronic Publication: 2018 Jan 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag. |
| مواضيع طبية MeSH: | Killer Cells, Natural/*pathology , Leukemia, Lymphocytic, Chronic, B-Cell/*diagnosis , Leukemia, Lymphocytic, Chronic, B-Cell/*immunology, Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/mortality ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphocyte Count ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Analysis |
| مستخلص: | Purpose: The aim of this study was to investigate the prognostic significance of the absolute natural killer (NK) cell counts in peripheral blood in patients with chronic lymphocytic leukemia (CLL). Methods: A total of 273 previously untreated patients with CLL from April 2004 and October 2015 were enrolled into this retrospective study. We analysed the T cell subsets of all patients and figured out the number of NK cells. Comparisons of NK cell count as continuous parameter in different groups were described using Mann-Whitney U test and the Kruskal-Wallis test. Kaplan-Meier method was used to survival analysis, and the Cox proportional hazards models were used for the estimation of prognostic factors. Results: NK cell counts were calculated in 273 therapy-naive CLL patients, and higher number of NK cell was observed in those with Binet stage A/B, ZAP-70 < 20%, normal serum albumin and β Conclusions: Our results suggest that NK cell count is an independent prognostic marker for OS in patients with CLL and NK cell counts ≥ 0.40 × 10 9 /L can routinely be used to identify patients with favorable survival. |
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| معلومات مُعتمدة: | 81370657 National Natural Science Foundation of China; 81770166 National Natural Science Foundation of China; 81470328 National Natural Science Foundation of China; 81720108002 National Natural Science Foundation of China |
| فهرسة مساهمة: | Keywords: Absolute NK cell count; Chronic lymphocytic leukemia; Dynamic; Host immunity; Prognosis |
| تواريخ الأحداث: | Date Created: 20180105 Date Completed: 20180226 Latest Revision: 20220408 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s00432-017-2568-2 |
| PMID: | 29299750 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1432-1335 |
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| DOI: | 10.1007/s00432-017-2568-2 |